SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xlu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D0V_A_NIOA991_1 (NICOTINATE MONONUCLEOTIDE:5,6-D IMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSF ERASE)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	4 / 8	GLY A 86 GLY A 149 LEU A 150 SER A 108	GLY A 86 ( 0.0A) GLY A 149 ( 0.0A) LEU A 150 ( 0.6A) SER A 108 ( 0.0A)	0.71A	1d0vA-5xluA: undetectable	1d0vA-5xluA: 14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FDS_A_ESTA350_1 (17-BETA-HYDROXYSTERO ID-DEHYDROGENASE)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	5 / 12	LEU A 150 GLY A 86 SER A 233 PHE A 236 MET A 162	LEU A 150 ( 0.6A) GLY A 86 ( 0.0A) SER A 233 ( 0.0A) PHE A 236 ( 1.3A) MET A 162 ( 0.0A)	1.42A	1fdsA-5xluA: undetectable	1fdsA-5xluA: 13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JHA_A_NIOA991_1 (NICOTINATE MONONUCLEOTIDE:5,6-D IMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSF ERASE)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	4 / 8	GLY A 86 GLY A 149 LEU A 150 SER A 108	GLY A 86 ( 0.0A) GLY A 149 ( 0.0A) LEU A 150 ( 0.6A) SER A 108 ( 0.0A)	0.72A	1jhaA-5xluA: undetectable	1jhaA-5xluA: 13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HRC_A_CHDA703_0 (FERROCHELATASE)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	4 / 4	LEU A 345 PRO A 344 LEU A 348 ARG A 331	LEU A 345 ( 0.5A) PRO A 344 ( 1.1A) LEU A 348 ( 0.5A) ARG A 331 ( 0.6A)	1.42A	2hrcA-5xluA: undetectable	2hrcA-5xluA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_C_SAMC300_1 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	4 / 4	SER A 108 GLY A 145 HIS A 154 ASP A 164	SER A 108 ( 0.0A) GLY A 145 ( 0.0A) HIS A 154 ( 1.0A) ASP A 164 ( 0.5A)	1.19A	2oxtC-5xluA: undetectable	2oxtC-5xluA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_B_KLNB1498_1 (CYTOCHROME P450 3A4)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	5 / 9	ILE A 387 ALA A 332 GLU A 356 GLY A 347 LEU A 348	ILE A 387 ( 0.7A) ALA A 332 ( 0.0A) GLU A 356 ( 0.5A) GLY A 347 ( 0.0A) LEU A 348 ( 0.5A)	1.18A	2v0mB-5xluA: undetectable	2v0mB-5xluA: 10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCN_B_CHDB1_0 (FERROCHELATASE, MITOCHONDRIAL)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	5 / 9	LEU A 150 PRO A 168 SER A 169 VAL A 59 GLY A 56	LEU A 150 ( 0.6A) PRO A 168 ( 1.1A) SER A 169 ( 0.0A) VAL A 59 ( 0.6A) GLY A 56 ( 0.0A)	1.38A	3hcnB-5xluA: undetectable	3hcnB-5xluA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCO_B_CHDB1_0 (FERROCHELATASE, MITOCHONDRIAL)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	4 / 4	LEU A 345 PRO A 344 LEU A 348 ARG A 331	LEU A 345 ( 0.5A) PRO A 344 ( 1.1A) LEU A 348 ( 0.5A) ARG A 331 ( 0.6A)	1.39A	3hcoB-5xluA: undetectable	3hcoB-5xluA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NVK_I_SAMI228_0 (FIBRILLARIN-LIKE RRNA/TRNA 2'-O-METHYLTRANSFERA SE)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	5 / 12	ALA A 235 ILE A 245 ASP A 247 ALA A 246 ASP A 238	ALA A 235 ( 0.0A) ILE A 245 ( 0.6A) ASP A 247 ( 0.6A) ALA A 246 ( 0.0A) ASP A 238 ( 0.5A)	1.10A	3nvkI-5xluA: undetectable	3nvkI-5xluA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V8V_A_SAMA801_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE L)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	5 / 12	ILE A 87 THR A 224 ASN A 78 PRO A 82 LEU A 183	ILE A 87 ( 0.6A) THR A 224 ( 0.8A) ASN A 78 ( 0.6A) PRO A 82 ( 1.1A) LEU A 183 ( 0.6A)	1.20A	3v8vA-5xluA: undetectable	3v8vA-5xluA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRI_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	4 / 5	LEU A 60 GLY A 64 THR A 159 ILE A 71	LEU A 60 ( 0.6A) GLY A 64 ( 0.0A) THR A 159 ( 0.8A) ILE A 71 ( 0.7A)	0.91A	3wriA-5xluA: undetectable	3wriA-5xluA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRI_B_CAMB502_0 (CAMPHOR 5-MONOOXYGENASE)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	4 / 5	LEU A 60 GLY A 64 THR A 159 ILE A 71	LEU A 60 ( 0.6A) GLY A 64 ( 0.0A) THR A 159 ( 0.8A) ILE A 71 ( 0.7A)	0.92A	3wriB-5xluA: undetectable	3wriB-5xluA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ZTV_A_ADNA1600_1 (NAD NUCLEOTIDASE)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	5 / 9	GLY A 89 GLY A 88 PHE A 236 SER A 108 GLY A 90	GLY A 89 ( 0.0A) GLY A 88 ( 0.0A) PHE A 236 ( 1.3A) SER A 108 ( 0.0A) GLY A 90 ( 0.0A)	1.26A	3ztvA-5xluA: undetectable	3ztvA-5xluA: 7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MUB_A_OAQA302_0 (SULFOTRANSFERASE)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	5 / 12	PRO A 338 VAL A 343 GLY A 373 ASP A 330 PHE A 293	PRO A 338 ( 1.1A) VAL A 343 ( 0.5A) GLY A 373 ( 0.0A) ASP A 330 ( 0.5A) PHE A 293 ( 1.3A)	1.45A	4mubA-5xluA: undetectable	4mubA-5xluA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LRB_A_ACRA1003_1 (ALPHA-1,4 GLUCAN PHOSPHORYLASE)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	4 / 6	GLU A 151 PHE A 225 THR A 224 TYR A 237	GLU A 151 ( 0.6A) PHE A 225 ( 1.3A) THR A 224 ( 0.8A) TYR A 237 ( 1.3A)	1.29A	5lrbA-5xluA: undetectable	5lrbA-5xluA: 6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W97_J_CHDJ101_1 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	4 / 5	TYR A 328 MET A 324 THR A 323 LEU A 320	TYR A 328 ( 1.3A) MET A 324 ( 0.0A) THR A 323 ( 0.8A) LEU A 320 ( 0.6A)	1.15A	5w97J-5xluA: undetectable	5w97J-5xluA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NKN_J_CHDJ102_0 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	4 / 5	TYR A 328 MET A 324 THR A 323 LEU A 320	TYR A 328 ( 1.3A) MET A 324 ( 0.0A) THR A 323 ( 0.8A) LEU A 320 ( 0.6A)	1.13A	6nknJ-5xluA: undetectable	6nknJ-5xluA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NKN_W_CHDW102_0 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	5xlu	GAMMA GLUTAMYL TRANSPEPTIDASE (Bacillus licheniformis)	4 / 5	TYR A 328 MET A 324 THR A 323 LEU A 320	TYR A 328 ( 1.3A) MET A 324 ( 0.0A) THR A 323 ( 0.8A) LEU A 320 ( 0.6A)	1.14A	6nknW-5xluA: undetectable	6nknW-5xluA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1D0V_A_NIOA991_1","NICOTINATE MONONUCLEOTIDE:5,6-DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",4,"GLY A  86;GLY A 149;LEU A 150;SER A 108","GLY A  86 ( 0.0A);GLY A 149 ( 0.0A);LEU A 150 ( 0.6A);SER A 108 ( 0.0A)","0.71A","1d0vA-5xluA:undetectable","1d0vA-5xluA:14.04"],["1FDS_A_ESTA350_1","17-BETA-HYDROXYSTEROID-DEHYDROGENASE","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",5,"LEU A 150;GLY A  86;SER A 233;PHE A 236;MET A 162","LEU A 150 ( 0.6A);GLY A  86 ( 0.0A);SER A 233 ( 0.0A);PHE A 236 ( 1.3A);MET A 162 ( 0.0A)","1.42A","1fdsA-5xluA:undetectable","1fdsA-5xluA:13.97"],["1JHA_A_NIOA991_1","NICOTINATE MONONUCLEOTIDE:5,6-DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",4,"GLY A  86;GLY A 149;LEU A 150;SER A 108","GLY A  86 ( 0.0A);GLY A 149 ( 0.0A);LEU A 150 ( 0.6A);SER A 108 ( 0.0A)","0.72A","1jhaA-5xluA:undetectable","1jhaA-5xluA:13.76"],["2HRC_A_CHDA703_0","FERROCHELATASE","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",4,"LEU A 345;PRO A 344;LEU A 348;ARG A 331","LEU A 345 ( 0.5A);PRO A 344 ( 1.1A);LEU A 348 ( 0.5A);ARG A 331 ( 0.6A)","1.42A","2hrcA-5xluA:undetectable","2hrcA-5xluA:undetectable"],["2OXT_C_SAMC300_1","NUCLEOSIDE-2'-O-METHYLTRANSFERASE","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",4,"SER A 108;GLY A 145;HIS A 154;ASP A 164","SER A 108 ( 0.0A);GLY A 145 ( 0.0A);HIS A 154 ( 1.0A);ASP A 164 ( 0.5A)","1.19A","2oxtC-5xluA:undetectable","2oxtC-5xluA:undetectable"],["2V0M_B_KLNB1498_1","CYTOCHROME P450 3A4","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",5,"ILE A 387;ALA A 332;GLU A 356;GLY A 347;LEU A 348","ILE A 387 ( 0.7A);ALA A 332 ( 0.0A);GLU A 356 ( 0.5A);GLY A 347 ( 0.0A);LEU A 348 ( 0.5A)","1.18A","2v0mB-5xluA:undetectable","2v0mB-5xluA:10.24"],["3HCN_B_CHDB1_0","FERROCHELATASE, MITOCHONDRIAL","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",5,"LEU A 150;PRO A 168;SER A 169;VAL A  59;GLY A  56","LEU A 150 ( 0.6A);PRO A 168 ( 1.1A);SER A 169 ( 0.0A);VAL A  59 ( 0.6A);GLY A  56 ( 0.0A)","1.38A","3hcnB-5xluA:undetectable","3hcnB-5xluA:undetectable"],["3HCO_B_CHDB1_0","FERROCHELATASE, MITOCHONDRIAL","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",4,"LEU A 345;PRO A 344;LEU A 348;ARG A 331","LEU A 345 ( 0.5A);PRO A 344 ( 1.1A);LEU A 348 ( 0.5A);ARG A 331 ( 0.6A)","1.39A","3hcoB-5xluA:undetectable","3hcoB-5xluA:undetectable"],["3NVK_I_SAMI228_0","FIBRILLARIN-LIKE RRNA\/TRNA 2'-O-METHYLTRANSFERASE","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",5,"ALA A 235;ILE A 245;ASP A 247;ALA A 246;ASP A 238","ALA A 235 ( 0.0A);ILE A 245 ( 0.6A);ASP A 247 ( 0.6A);ALA A 246 ( 0.0A);ASP A 238 ( 0.5A)","1.10A","3nvkI-5xluA:undetectable","3nvkI-5xluA:undetectable"],["3V8V_A_SAMA801_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE L","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",5,"ILE A  87;THR A 224;ASN A  78;PRO A  82;LEU A 183","ILE A  87 ( 0.6A);THR A 224 ( 0.8A);ASN A  78 ( 0.6A);PRO A  82 ( 1.1A);LEU A 183 ( 0.6A)","1.20A","3v8vA-5xluA:undetectable","3v8vA-5xluA:undetectable"],["3WRI_A_CAMA502_0","CAMPHOR 5-MONOOXYGENASE","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",4,"LEU A  60;GLY A  64;THR A 159;ILE A  71","LEU A  60 ( 0.6A);GLY A  64 ( 0.0A);THR A 159 ( 0.8A);ILE A  71 ( 0.7A)","0.91A","3wriA-5xluA:undetectable","3wriA-5xluA:undetectable"],["3WRI_B_CAMB502_0","CAMPHOR 5-MONOOXYGENASE","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",4,"LEU A  60;GLY A  64;THR A 159;ILE A  71","LEU A  60 ( 0.6A);GLY A  64 ( 0.0A);THR A 159 ( 0.8A);ILE A  71 ( 0.7A)","0.92A","3wriB-5xluA:undetectable","3wriB-5xluA:undetectable"],["3ZTV_A_ADNA1600_1","NAD NUCLEOTIDASE","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",5,"GLY A  89;GLY A  88;PHE A 236;SER A 108;GLY A  90","GLY A  89 ( 0.0A);GLY A  88 ( 0.0A);PHE A 236 ( 1.3A);SER A 108 ( 0.0A);GLY A  90 ( 0.0A)","1.26A","3ztvA-5xluA:undetectable","3ztvA-5xluA:7.94"],["4MUB_A_OAQA302_0","SULFOTRANSFERASE","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",5,"PRO A 338;VAL A 343;GLY A 373;ASP A 330;PHE A 293","PRO A 338 ( 1.1A);VAL A 343 ( 0.5A);GLY A 373 ( 0.0A);ASP A 330 ( 0.5A);PHE A 293 ( 1.3A)","1.45A","4mubA-5xluA:undetectable","4mubA-5xluA:undetectable"],["5LRB_A_ACRA1003_1","ALPHA-1,4 GLUCAN PHOSPHORYLASE","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",4,"GLU A 151;PHE A 225;THR A 224;TYR A 237","GLU A 151 ( 0.6A);PHE A 225 ( 1.3A);THR A 224 ( 0.8A);TYR A 237 ( 1.3A)","1.29A","5lrbA-5xluA:undetectable","5lrbA-5xluA:6.26"],["5W97_J_CHDJ101_1","CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",4,"TYR A 328;MET A 324;THR A 323;LEU A 320","TYR A 328 ( 1.3A);MET A 324 ( 0.0A);THR A 323 ( 0.8A);LEU A 320 ( 0.6A)","1.15A","5w97J-5xluA:undetectable","5w97J-5xluA:undetectable"],["6NKN_J_CHDJ102_0","CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",4,"TYR A 328;MET A 324;THR A 323;LEU A 320","TYR A 328 ( 1.3A);MET A 324 ( 0.0A);THR A 323 ( 0.8A);LEU A 320 ( 0.6A)","1.13A","6nknJ-5xluA:undetectable","6nknJ-5xluA:undetectable"],["6NKN_W_CHDW102_0","CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","5xlu","GAMMA GLUTAMYL TRANSPEPTIDASE","Bacillus licheniformis",4,"TYR A 328;MET A 324;THR A 323;LEU A 320","TYR A 328 ( 1.3A);MET A 324 ( 0.0A);THR A 323 ( 0.8A);LEU A 320 ( 0.6A)","1.14A","6nknW-5xluA:undetectable","6nknW-5xluA:undetectable"]]