SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 5xly CHEMOTAXIS PROTEIN
METHYLTRANSFERASE 1
(Pseudomonas
aeruginosa) 		4 / 8 VAL A 219
LEU A 201
TYR A 205
VAL A 214
 None
 0.95A 1jtvA-5xlyA:
undetectable		 1jtvA-5xlyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5xly CHEMOTAXIS PROTEIN
METHYLTRANSFERASE 1
CYCLIC DIGUANOSINE
MONOPHOSPHATE-BINDIN
G PROTEIN PA4608
(Pseudomonas
aeruginosa) 		3 / 3 ARG B 100
GLU B 103
SER A  33
 None
 0.85A 2xctD-5xlyB:
undetectable		 2xctD-5xlyB:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 5xly CYCLIC DIGUANOSINE
MONOPHOSPHATE-BINDIN
G PROTEIN PA4608
(Pseudomonas
aeruginosa) 		5 / 11 VAL B  43
LEU B  83
GLY B  84
SER B  74
PRO B  56
 None
None
C2E  B 202 ( 4.2A)
None
None
 1.30A 3bjwB-5xlyB:
undetectable		 3bjwB-5xlyB:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 5xly CYCLIC DIGUANOSINE
MONOPHOSPHATE-BINDIN
G PROTEIN PA4608
(Pseudomonas
aeruginosa) 		5 / 11 VAL B  43
LEU B  83
GLY B  84
SER B  74
PRO B  56
 None
None
C2E  B 202 ( 4.2A)
None
None
 1.36A 3bjwE-5xlyB:
undetectable		 3bjwE-5xlyB:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 5xly CYCLIC DIGUANOSINE
MONOPHOSPHATE-BINDIN
G PROTEIN PA4608
(Pseudomonas
aeruginosa) 		5 / 11 VAL B  43
LEU B  83
GLY B  84
SER B  74
PRO B  56
 None
None
C2E  B 202 ( 4.2A)
None
None
 1.32A 3bjwH-5xlyB:
undetectable		 3bjwH-5xlyB:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5xly CYCLIC DIGUANOSINE
MONOPHOSPHATE-BINDIN
G PROTEIN PA4608
(Pseudomonas
aeruginosa) 		5 / 12 ILE B  73
ILE B  41
LEU B  68
LEU B  23
ARG B  60
 None
 1.13A 3em0B-5xlyB:
undetectable		 3em0B-5xlyB:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 5xly CHEMOTAXIS PROTEIN
METHYLTRANSFERASE 1
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  61
GLU A  63
MET A  69
LEU A  35
 None
 1.15A 4xi3B-5xlyA:
undetectable		 4xi3B-5xlyA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5xly CHEMOTAXIS PROTEIN
METHYLTRANSFERASE 1
(Pseudomonas
aeruginosa) 		4 / 6 CYH A 216
LEU A 247
HIS A 236
LEU A 232
 None
 1.15A 5hpuC-5xlyA:
undetectable
5hpuD-5xlyA:
undetectable		 5hpuC-5xlyA:
7.04
5hpuD-5xlyA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 5xly CYCLIC DIGUANOSINE
MONOPHOSPHATE-BINDIN
G PROTEIN PA4608
(Pseudomonas
aeruginosa) 		3 / 3 LEU B  38
LEU B 112
ARG B  99
 None
 0.64A 6fgcA-5xlyB:
undetectable		 6fgcA-5xlyB:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 5xly CYCLIC DIGUANOSINE
MONOPHOSPHATE-BINDIN
G PROTEIN PA4608
(Pseudomonas
aeruginosa) 		3 / 3 LEU B  38
LEU B 112
ARG B  99
 None
 0.67A 6fgdA-5xlyB:
undetectable		 6fgdA-5xlyB:
14.53