SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xm3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		3 / 3 ALA A 143
VAL A  46
TRP A  45
 None
 0.94A 1c4dC-5xm3A:
undetectable
1c4dD-5xm3A:
undetectable		 1c4dC-5xm3A:
undetectable
1c4dD-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 9 GLY A 604
GLU A  86
GLY A  84
GLY A 549
GLY A  87
 None
PQQ  A 701 (-2.5A)
None
None
None
 1.15A 1mxdA-5xm3A:
undetectable		 1mxdA-5xm3A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 11 GLY A 604
GLU A  86
GLY A  84
GLY A 549
GLY A  87
 None
PQQ  A 701 (-2.5A)
None
None
None
 1.13A 1mxgA-5xm3A:
undetectable		 1mxgA-5xm3A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 GLY A 364
ALA A 379
MET A 382
GLY A 337
HIS A 359
 None
 1.13A 1nbiC-5xm3A:
undetectable		 1nbiC-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 GLY A 364
ALA A 379
MET A 382
GLY A 337
HIS A 359
 None
 1.12A 1nbiD-5xm3A:
undetectable		 1nbiD-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 9 ALA A 529
PHE A 519
GLY A 515
LEU A 611
LEU A  71
 None
 1.05A 1nr6A-5xm3A:
undetectable		 1nr6A-5xm3A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 TYR A 335
PRO A 329
PRO A 418
ILE A 365
LEU A 376
 None
 0.98A 1z9hA-5xm3A:
undetectable		 1z9hA-5xm3A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 TYR A 335
PRO A 329
PRO A 418
ILE A 365
LEU A 376
 None
 0.97A 1z9hB-5xm3A:
undetectable		 1z9hB-5xm3A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 TYR A 335
PRO A 329
PRO A 418
ILE A 365
LEU A 376
 None
 0.98A 1z9hC-5xm3A:
undetectable		 1z9hC-5xm3A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 7 TYR A 214
GLY A 203
THR A 216
TYR A 218
ASN A 273
 None
 1.37A 2g70A-5xm3A:
undetectable		 2g70A-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 7 TYR A 214
GLY A 203
THR A 216
TYR A 218
ASN A 273
 None
 1.38A 2g70B-5xm3A:
undetectable		 2g70B-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 6 TYR A 214
GLY A 203
TYR A 218
ASN A 273
 None
 1.15A 2g72A-5xm3A:
undetectable		 2g72A-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 GLY A  87
GLY A 509
GLY A 549
LEU A 440
VAL A 340
 None
 1.05A 2oxtA-5xm3A:
undetectable		 2oxtA-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		3 / 3 ARG A 140
ASP A 361
ASN A 425
 PQQ  A 701 (-3.3A)
None
PQQ  A 701 (-3.4A)
 0.83A 2zzmA-5xm3A:
undetectable		 2zzmA-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		3 / 3 GLY A 549
GLY A 427
GLY A 508
 None
 0.37A 3bogD-5xm3A:
undetectable		 3bogD-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 4 VAL A 416
ARG A 362
ILE A 365
THR A 407
 None
PQQ  A 701 (-2.8A)
None
None
 1.15A 3cl9A-5xm3A:
undetectable		 3cl9A-5xm3A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		3 / 3 THR A 216
GLU A 189
HIS A 163
 None
 0.79A 3g1uB-5xm3A:
undetectable		 3g1uB-5xm3A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 5xm3 GLUCOSE
DEHYDROGENASE
METHANOL
DEHYDROGENASE
[CYTOCHROME C]
SUBUNIT 2
(Methylophaga
aminisulfidivora
ns;
Methylophaga
aminisulfidivora
ns) 		3 / 3 VAL A 178
VAL B  79
TRP A 176
 None
 0.77A 3l8lA-5xm3A:
undetectable
3l8lB-5xm3A:
undetectable		 3l8lA-5xm3A:
undetectable
3l8lB-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		3 / 3 GLY A 509
TRP A 276
VAL A 340
 None
 0.64A 3n62B-5xm3A:
undetectable		 3n62B-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		3 / 3 GLY A 509
TRP A 276
VAL A 340
 None
 0.62A 3n65B-5xm3A:
undetectable		 3n65B-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		3 / 3 GLY A 509
TRP A 276
VAL A 340
 None
 0.64A 3n66B-5xm3A:
undetectable		 3n66B-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 8 ASP A 334
GLY A 337
GLU A 208
ARG A 140
 MG  A 702 (-3.5A)
None
MG  A 702 ( 2.2A)
PQQ  A 701 (-3.3A)
 0.95A 3s3mA-5xm3A:
undetectable		 3s3mA-5xm3A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 ASN A 264
GLY A 233
ALA A 207
GLY A 210
ASN A 292
 None
None
PQQ  A 701 (-3.0A)
None
MG  A 702 ( 3.0A)
 1.16A 3v3oA-5xm3A:
undetectable		 3v3oA-5xm3A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 ASN A 264
GLY A 233
ALA A 207
GLY A 210
ASN A 292
 None
None
PQQ  A 701 (-3.0A)
None
MG  A 702 ( 3.0A)
 1.23A 3v3oB-5xm3A:
undetectable		 3v3oB-5xm3A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 6 GLY A 406
GLU A 332
ASP A 304
ASP A 402
 None
 0.88A 3vywC-5xm3A:
undetectable		 3vywC-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 11 ASN A 264
GLY A 233
ALA A 207
GLY A 210
ASN A 292
 None
None
PQQ  A 701 (-3.0A)
None
MG  A 702 ( 3.0A)
 1.30A 4a6nA-5xm3A:
undetectable		 4a6nA-5xm3A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 ASP A 361
ASN A 339
GLY A 291
ASN A 292
ARG A 301
 None
None
None
MG  A 702 ( 3.0A)
None
 1.33A 4djeB-5xm3A:
undetectable		 4djeB-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 11 ALA A 207
GLY A 270
GLY A 289
ASN A 292
TRP A 274
 PQQ  A 701 (-3.0A)
None
None
MG  A 702 ( 3.0A)
PQQ  A 701 (-3.4A)
 1.23A 4e47A-5xm3A:
undetectable		 4e47A-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 11 ALA A 207
GLY A 270
GLY A 289
ASN A 292
TRP A 274
 PQQ  A 701 (-3.0A)
None
None
MG  A 702 ( 3.0A)
PQQ  A 701 (-3.4A)
 1.27A 4e47B-5xm3A:
undetectable		 4e47B-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 11 ALA A 207
GLY A 270
GLY A 289
ASN A 292
TRP A 274
 PQQ  A 701 (-3.0A)
None
None
MG  A 702 ( 3.0A)
PQQ  A 701 (-3.4A)
 1.24A 4jdsA-5xm3A:
undetectable		 4jdsA-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 11 ALA A 207
GLY A 270
GLY A 289
ASN A 292
TRP A 274
 PQQ  A 701 (-3.0A)
None
None
MG  A 702 ( 3.0A)
PQQ  A 701 (-3.4A)
 1.22A 4jdsB-5xm3A:
undetectable		 4jdsB-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 7 GLN A 202
THR A 216
THR A 308
MET A 309
 None
 0.98A 4mbsA-5xm3A:
undetectable		 4mbsA-5xm3A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 HIS A 163
THR A 188
ARG A 228
GLY A 203
THR A 216
 None
 1.04A 4qvnH-5xm3A:
undetectable
4qvnN-5xm3A:
undetectable		 4qvnH-5xm3A:
17.80
4qvnN-5xm3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 11 HIS A 163
THR A 188
ARG A 228
GLY A 203
THR A 216
 None
 1.04A 4qvpV-5xm3A:
undetectable
4qvpb-5xm3A:
undetectable		 4qvpV-5xm3A:
17.80
4qvpb-5xm3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 11 HIS A 163
THR A 188
ARG A 228
GLY A 203
THR A 216
 None
 1.04A 4qvpH-5xm3A:
undetectable
4qvpN-5xm3A:
undetectable		 4qvpH-5xm3A:
17.80
4qvpN-5xm3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		3 / 3 SER A 610
TYR A 561
ASP A 618
 None
 0.86A 4rp8C-5xm3A:
undetectable		 4rp8C-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 GLY A 213
GLY A 271
GLY A 206
ALA A 207
ILE A 183
 None
None
PQQ  A 701 (-3.7A)
PQQ  A 701 (-3.0A)
None
 1.03A 4rtmA-5xm3A:
undetectable		 4rtmA-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5xm3 GLUCOSE
DEHYDROGENASE
METHANOL
DEHYDROGENASE
[CYTOCHROME C]
SUBUNIT 2
(Methylophaga
aminisulfidivora
ns;
Methylophaga
aminisulfidivora
ns) 		4 / 5 TYR B  25
LYS B  40
PRO B  41
GLU A 298
 None
 1.26A 4w5tA-5xm3B:
undetectable		 4w5tA-5xm3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5xm3 GLUCOSE
DEHYDROGENASE
METHANOL
DEHYDROGENASE
[CYTOCHROME C]
SUBUNIT 2
(Methylophaga
aminisulfidivora
ns;
Methylophaga
aminisulfidivora
ns) 		4 / 6 TYR B  25
LYS B  40
PRO B  41
GLU A 298
 None
 1.27A 4z4cA-5xm3B:
undetectable		 4z4cA-5xm3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5xm3 GLUCOSE
DEHYDROGENASE
METHANOL
DEHYDROGENASE
[CYTOCHROME C]
SUBUNIT 2
(Methylophaga
aminisulfidivora
ns;
Methylophaga
aminisulfidivora
ns) 		4 / 6 TYR B  25
LYS B  40
PRO B  41
GLU A 298
 None
 1.23A 4z4gA-5xm3B:
undetectable		 4z4gA-5xm3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 11 ALA A 207
GLY A 270
GLY A 289
ASN A 292
TRP A 274
 PQQ  A 701 (-3.0A)
None
None
MG  A 702 ( 3.0A)
PQQ  A 701 (-3.4A)
 1.28A 5ayfA-5xm3A:
undetectable		 5ayfA-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 9 ASP A 524
LEU A 523
GLY A 546
LEU A 576
ALA A 573
 None
 1.06A 5dqfA-5xm3A:
undetectable		 5dqfA-5xm3A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 6 TRP A 571
GLY A 588
THR A 469
VAL A 467
 PQQ  A 701 (-4.6A)
None
None
None
 1.11A 5ewuA-5xm3A:
undetectable		 5ewuA-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		4 / 6 TYR A 617
ASP A 110
ILE A 117
TYR A 554
 None
 1.11A 5ih0A-5xm3A:
undetectable		 5ih0A-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5xm3 GLUCOSE
DEHYDROGENASE
METHANOL
DEHYDROGENASE
[CYTOCHROME C]
SUBUNIT 2
(Methylophaga
aminisulfidivora
ns;
Methylophaga
aminisulfidivora
ns) 		3 / 3 GLY A 270
GLY A 269
GLN B  64
 None
 0.36A 5imsA-5xm3A:
undetectable		 5imsA-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xm3 GLUCOSE
DEHYDROGENASE
METHANOL
DEHYDROGENASE
[CYTOCHROME C]
SUBUNIT 2
(Methylophaga
aminisulfidivora
ns) 		4 / 5 TYR B  25
GLY B  27
THR B  28
GLY A 213
 None
 0.77A 5jlcA-5xm3B:
undetectable		 5jlcA-5xm3B:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		3 / 3 GLY A 509
TRP A 276
VAL A 340
 None
 0.63A 5vuoB-5xm3A:
undetectable		 5vuoB-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		3 / 3 LYS A 528
LEU A 537
ARG A 530
 None
 0.87A 5yw0A-5xm3A:
undetectable		 5yw0A-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		3 / 3 MET A 309
ASP A 334
ARG A 140
 None
MG  A 702 (-3.5A)
PQQ  A 701 (-3.3A)
 1.19A 5z6kA-5xm3A:
undetectable		 5z6kA-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 10 GLY A 291
GLY A 337
ASP A 334
THR A 308
ASN A 305
 None
None
MG  A 702 (-3.5A)
None
None
 1.21A 6exiA-5xm3A:
undetectable		 6exiA-5xm3A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 10 GLY A 291
GLY A 337
ASP A 334
THR A 308
ASN A 305
 None
None
MG  A 702 (-3.5A)
None
None
 1.21A 6exiB-5xm3A:
undetectable		 6exiB-5xm3A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 GLY A 291
GLY A 337
ASP A 334
THR A 308
ASN A 305
 None
None
MG  A 702 (-3.5A)
None
None
 1.20A 6exiC-5xm3A:
undetectable
6exiD-5xm3A:
undetectable		 6exiC-5xm3A:
17.58
6exiD-5xm3A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 VAL A 164
VAL A  46
SER A  39
ASN A  32
VAL A 200
 None
 1.28A 6h7lA-5xm3A:
undetectable		 6h7lA-5xm3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 VAL A 164
VAL A  46
SER A  39
ASN A  32
VAL A 200
 None
 1.29A 6h7lB-5xm3A:
undetectable		 6h7lB-5xm3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 HIS A 163
THR A 188
ARG A 228
GLY A 203
THR A 216
 None
 1.05A 6hwdV-5xm3A:
undetectable
6hwdb-5xm3A:
undetectable		 6hwdV-5xm3A:
16.67
6hwdb-5xm3A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 5xm3 GLUCOSE
DEHYDROGENASE
(Methylophaga
aminisulfidivora
ns) 		5 / 12 HIS A 163
THR A 188
ARG A 228
GLY A 203
THR A 216
 None
 1.05A 6hwdH-5xm3A:
undetectable
6hwdN-5xm3A:
undetectable		 6hwdH-5xm3A:
16.67
6hwdN-5xm3A:
25.00