SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xmb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_A_PAUA6001_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		7 / 9 ASP A 129
LEU A 132
GLY A 148
LEU A 203
TYR A 235
ILE A 276
ASN A 277
 None
 0.84A 1sq5A-5xmbA:
36.0		 1sq5A-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_A_PAUA6001_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		5 / 9 ASP A 129
LYS A 147
TYR A 235
ILE A 276
ASN A 277
 None
 0.85A 1sq5A-5xmbA:
36.0		 1sq5A-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		7 / 10 ASP A 129
LEU A 132
GLY A 148
HIS A 179
LEU A 203
ILE A 276
ASN A 277
 None
 0.99A 1sq5B-5xmbA:
36.2		 1sq5B-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		8 / 10 ASP A 129
LEU A 132
GLY A 148
TYR A 182
LEU A 203
TYR A 235
ILE A 276
ASN A 277
 None
 0.93A 1sq5B-5xmbA:
36.2		 1sq5B-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		5 / 10 ASP A 129
LYS A 147
TYR A 235
ILE A 276
ASN A 277
 None
 0.86A 1sq5B-5xmbA:
36.2		 1sq5B-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_C_PAUC6002_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		7 / 9 ASP A 129
LEU A 132
GLY A 148
LEU A 203
TYR A 235
ILE A 276
ASN A 277
 None
 0.82A 1sq5C-5xmbA:
35.4		 1sq5C-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_C_PAUC6002_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		5 / 9 ASP A 129
LYS A 147
TYR A 235
ILE A 276
ASN A 277
 None
 0.86A 1sq5C-5xmbA:
35.4		 1sq5C-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		8 / 10 VAL A  99
ASP A 129
LEU A 132
GLY A 148
LEU A 203
TYR A 235
ILE A 276
ASN A 277
 SO4  A 401 ( 4.2A)
None
None
None
None
None
None
None
 0.86A 1sq5D-5xmbA:
35.9		 1sq5D-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		5 / 10 VAL A  99
ASP A 129
LEU A 132
HIS A 179
LEU A 203
 SO4  A 401 ( 4.2A)
None
None
None
None
 0.94A 1sq5D-5xmbA:
35.9		 1sq5D-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		6 / 10 VAL A  99
ASP A 129
LYS A 147
TYR A 235
ILE A 276
ASN A 277
 SO4  A 401 ( 4.2A)
None
None
None
None
None
 0.90A 1sq5D-5xmbA:
35.9		 1sq5D-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		5 / 6 VAL A  99
ASP A 129
LYS A 147
HIS A 179
ASN A 277
 SO4  A 401 ( 4.2A)
None
None
None
None
 1.17A 2zs9A-5xmbA:
37.6		 2zs9A-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		4 / 6 VAL A  99
ASP A 129
TYR A 182
ASN A 277
 SO4  A 401 ( 4.2A)
None
None
None
 1.09A 2zs9A-5xmbA:
37.6		 2zs9A-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		5 / 7 TYR A 235
PHE A 239
MET A 242
ILE A 272
ASN A 277
 None
 0.55A 2zseA-5xmbA:
37.3		 2zseA-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  99
ASP A 129
GLY A 148
TYR A 182
 SO4  A 401 ( 4.2A)
None
None
None
 0.83A 3af0A-5xmbA:
37.8		 3af0A-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		6 / 8 VAL A  99
ASP A 129
LEU A 132
GLY A 148
TYR A 153
HIS A 179
 SO4  A 401 ( 4.2A)
None
None
None
None
None
 0.72A 3af0A-5xmbA:
37.8		 3af0A-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVO_A_PAUA314_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		8 / 11 VAL A  99
ASP A 129
LEU A 132
TYR A 153
TYR A 177
HIS A 179
ILE A 276
ASN A 277
 SO4  A 401 ( 4.2A)
None
None
None
None
None
None
None
 0.87A 3avoA-5xmbA:
37.7		 3avoA-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVO_A_PAUA314_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		7 / 11 VAL A  99
ASP A 129
LYS A 147
TYR A 177
HIS A 179
ILE A 276
ASN A 277
 SO4  A 401 ( 4.2A)
None
None
None
None
None
None
 1.17A 3avoA-5xmbA:
37.7		 3avoA-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVO_A_PAUA314_0
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		7 / 11 VAL A  99
ASP A 129
TYR A 177
HIS A 179
TYR A 182
ILE A 276
ASN A 277
 SO4  A 401 ( 4.2A)
None
None
None
None
None
None
 1.12A 3avoA-5xmbA:
37.7		 3avoA-5xmbA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		7 / 7 VAL A  99
ASP A 129
HIS A 179
LEU A 203
TYR A 235
ILE A 272
ASN A 277
 SO4  A 401 ( 4.2A)
None
None
None
None
None
None
 0.76A 3avpA-5xmbA:
37.7		 3avpA-5xmbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 138
ASN A 142
SER A 152
PHE A 149
 None
 1.46A 3i9jB-5xmbA:
undetectable		 3i9jB-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		5 / 10 ILE A  92
GLY A  94
VAL A  95
VAL A 123
ILE A 197
 None
 1.07A 3oxvB-5xmbA:
undetectable		 3oxvB-5xmbA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		5 / 11 THR A 293
ALA A 292
LEU A 206
PHE A  91
ILE A  60
 None
 1.27A 4claA-5xmbA:
undetectable		 4claA-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  96
GLY A  97
SER A  98
ASN A 204
GLY A  94
 None
 1.12A 4obwA-5xmbA:
undetectable		 4obwA-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 168
VAL A  89
PHE A 218
ILE A  92
 None
 1.14A 4xv2B-5xmbA:
undetectable		 4xv2B-5xmbA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 172
PHE A 161
THR A 128
PRO A 195
LEU A 198
 None
 1.33A 5mm4B-5xmbA:
2.0		 5mm4B-5xmbA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5xmb PANTOTHENATE KINASE
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 207
VAL A 205
PRO A 150
THR A 127
 None
 1.19A 6cduA-5xmbA:
undetectable
6cduB-5xmbA:
undetectable		 6cduA-5xmbA:
undetectable
6cduB-5xmbA:
undetectable