SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xmc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		4 / 7 PHE A 803
THR A 793
VAL A 792
ALA A 758
 None
 1.05A 1fo4B-5xmcA:
undetectable		 1fo4B-5xmcA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		5 / 12 ILE A 780
THR A 793
LEU A 788
LEU A 798
ILE A 749
 None
 1.33A 1kqwA-5xmcA:
undetectable		 1kqwA-5xmcA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		3 / 3 CYH A 744
ARG A 378
CYH A 796
 None
 1.48A 1p9gA-5xmcA:
undetectable		 1p9gA-5xmcA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		3 / 3 VAL A 553
ALA A 554
HIS A 612
 None
 0.73A 1q23L-5xmcA:
undetectable		 1q23L-5xmcA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		5 / 12 TYR A 841
LEU A 838
TYR A 844
GLN A 846
PHE A 776
 None
 1.45A 1s2aA-5xmcA:
undetectable		 1s2aA-5xmcA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		4 / 7 ILE A 602
ARG A 627
PHE A 624
ILE A 628
 None
 1.10A 2qb4A-5xmcA:
undetectable		 2qb4A-5xmcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		4 / 8 SER A 522
PHE A 601
VAL A 565
PHE A 558
 None
 1.26A 2wekA-5xmcA:
undetectable		 2wekA-5xmcA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		4 / 4 ARG A 600
GLY A 603
GLU A 724
SER A 589
 None
 1.33A 2xctS-5xmcA:
undetectable
2xctU-5xmcA:
undetectable		 2xctS-5xmcA:
21.59
2xctU-5xmcA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		4 / 8 ARG A 535
LEU A 534
ARG A 604
GLU A 724
 None
 1.31A 3zmdA-5xmcA:
undetectable
3zmdB-5xmcA:
undetectable		 3zmdA-5xmcA:
12.69
3zmdB-5xmcA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		4 / 6 GLU A 520
TYR A 598
HIS A 595
PHE A 519
 None
 1.11A 4a97E-5xmcA:
2.4		 4a97E-5xmcA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		4 / 6 GLU A 520
TYR A 598
HIS A 595
PHE A 523
 None
 1.04A 4a97E-5xmcA:
2.4		 4a97E-5xmcA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		3 / 3 PRO A 568
MET A 569
TYR A 358
 None
 0.99A 4qa0B-5xmcA:
undetectable		 4qa0B-5xmcA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		3 / 3 PRO A 568
MET A 569
TYR A 358
 None
 1.00A 4qa0A-5xmcA:
undetectable		 4qa0A-5xmcA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		3 / 3 PRO A 568
MET A 569
TYR A 358
 None
 0.99A 4qa2B-5xmcA:
undetectable		 4qa2B-5xmcA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		4 / 6 LEU A 368
VAL A 800
ARG A 797
PHE A 375
 None
 1.27A 4uswA-5xmcA:
undetectable		 4uswA-5xmcA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		5 / 12 GLY A 721
GLY A 603
GLU A 724
ILE A 725
PHE A 523
 None
 1.19A 4zvmA-5xmcA:
undetectable
4zvmB-5xmcA:
undetectable		 4zvmA-5xmcA:
16.30
4zvmB-5xmcA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		5 / 11 PHE A 523
GLY A 721
GLY A 603
GLU A 724
ILE A 725
 None
 1.14A 4zvmA-5xmcA:
undetectable
4zvmB-5xmcA:
undetectable		 4zvmA-5xmcA:
16.30
4zvmB-5xmcA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		4 / 6 PHE A 605
ALA A 607
HIS A 612
LEU A 534
 None
 1.07A 5dzkB-5xmcA:
undetectable
5dzkP-5xmcA:
undetectable		 5dzkB-5xmcA:
15.23
5dzkP-5xmcA:
0.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		5 / 9 ILE A 585
LEU A 572
ARG A 600
ILE A 602
GLY A 603
 None
 1.05A 5ifuB-5xmcA:
undetectable		 5ifuB-5xmcA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		4 / 5 LEU A 610
PHE A 611
LEU A 742
PHE A 734
 None
 1.16A 5iy5P-5xmcA:
undetectable
5iy5W-5xmcA:
undetectable		 5iy5P-5xmcA:
15.43
5iy5W-5xmcA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		5 / 12 PHE A 624
PHE A 601
PHE A 573
ILE A 511
ALA A 554
 None
 1.20A 5vc0A-5xmcA:
undetectable		 5vc0A-5xmcA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		5 / 12 GLU A 556
LEU A 561
TYR A 625
CYH A 744
PHE A 375
 None
 1.40A 5vlmC-5xmcA:
2.2		 5vlmC-5xmcA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		4 / 6 LEU A 610
PHE A 611
LEU A 742
PHE A 734
 None
 1.08A 5w97C-5xmcA:
undetectable
5w97J-5xmcA:
undetectable		 5w97C-5xmcA:
15.72
5w97J-5xmcA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		4 / 5 LEU A 610
PHE A 611
PHE A 496
LEU A 731
 None
 1.10A 5x1bP-5xmcA:
undetectable		 5x1bP-5xmcA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		4 / 5 LEU A 610
PHE A 611
LEU A 742
PHE A 734
 None
 1.14A 5x1fC-5xmcA:
undetectable
5x1fJ-5xmcA:
undetectable		 5x1fC-5xmcA:
15.72
5x1fJ-5xmcA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		4 / 5 LEU A 610
PHE A 611
LEU A 742
PHE A 734
 None
 1.10A 5xdxC-5xmcA:
undetectable
5xdxJ-5xmcA:
undetectable		 5xdxC-5xmcA:
16.12
5xdxJ-5xmcA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY
(Mus
musculus) 		4 / 5 LEU A 610
PHE A 611
LEU A 742
PHE A 734
 None
 1.15A 5xdxP-5xmcA:
undetectable
5xdxW-5xmcA:
undetectable		 5xdxP-5xmcA:
16.12
5xdxW-5xmcA:
5.38