SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xmg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa)
5 / 9 ILE A 337
VAL A 335
THR A 327
ALA A 301
LEU A 294
None
1.11A 2m9qA-5xmgA:
undetectable
2m9qA-5xmgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa)
3 / 3 PHE A 223
PHE A  82
PHE A 187
None
0.86A 2od9A-5xmgA:
undetectable
2od9A-5xmgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa)
3 / 3 PHE A 223
PHE A  82
PHE A 187
None
0.86A 2qqgA-5xmgA:
undetectable
2qqgA-5xmgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa)
3 / 3 TYR A 213
GLU A  28
ASN A 240
None
0.99A 2y7hC-5xmgA:
undetectable
2y7hC-5xmgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa)
4 / 6 SER A  74
TYR A  46
SER A 253
GLN A 340
None
1.40A 2zvjA-5xmgA:
undetectable
2zvjA-5xmgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa)
5 / 11 ASP A 230
ILE A 228
GLY A 220
PHE A 187
GLY A 226
None
1.09A 4ac9B-5xmgA:
undetectable
4ac9C-5xmgA:
undetectable
4ac9B-5xmgA:
undetectable
4ac9C-5xmgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa)
4 / 5 PHE A  82
ILE A 221
GLY A  31
THR A 256
None
1.01A 4ejjC-5xmgA:
undetectable
4ejjC-5xmgA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa)
5 / 10 GLY A  73
LEU A 255
ALA A 257
ASP A 261
ALA A 235
None
0.92A 4wnuD-5xmgA:
undetectable
4wnuD-5xmgA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa)
4 / 5 GLN A 108
HIS A 110
ILE A 149
ILE A 115
None
1.26A 5dnvA-5xmgA:
undetectable
5dnvA-5xmgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa)
5 / 12 ALA A 336
ASP A 275
GLY A 323
THR A 341
GLU A 304
None
1.38A 5hfjG-5xmgA:
undetectable
5hfjG-5xmgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa)
4 / 7 ILE A 370
HIS A 295
LEU A 294
ALA A 301
None
0.98A 5hrqE-5xmgA:
undetectable
5hrqF-5xmgA:
undetectable
5hrqJ-5xmgA:
undetectable
5hrqE-5xmgA:
undetectable
5hrqF-5xmgA:
undetectable
5hrqJ-5xmgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa)
4 / 8 GLN A 340
GLY A 323
ILE A 337
ASP A 292
None
0.94A 5vlmH-5xmgA:
undetectable
5vlmH-5xmgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa)
4 / 8 GLY A 270
LEU A 271
GLN A 338
ALA A 336
None
0.93A 5xu8A-5xmgA:
undetectable
5xu8A-5xmgA:
undetectable