SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xmi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 186
LEU A 273
ILE A 296
GLY A 140
ALA A 141
LEU A 145
 None
 1.30A 1eqhA-5xmiA:
undetectable		 1eqhA-5xmiA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 186
LEU A 273
ILE A 296
GLY A 140
ALA A 141
LEU A 145
 None
 1.32A 1eqhB-5xmiA:
undetectable		 1eqhB-5xmiA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 187
LEU A 273
LEU A 145
ILE A 296
LEU A 138
 None
 1.09A 1qzfA-5xmiA:
undetectable		 1qzfA-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 187
LEU A 273
LEU A 145
ILE A 296
LEU A 138
 None
 1.09A 1qzfB-5xmiA:
undetectable		 1qzfB-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 187
LEU A 273
LEU A 145
ILE A 296
LEU A 138
 None
 1.09A 1qzfC-5xmiA:
undetectable		 1qzfC-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 187
LEU A 273
LEU A 145
ILE A 296
LEU A 138
 None
 1.09A 1qzfD-5xmiA:
undetectable		 1qzfD-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 187
LEU A 273
LEU A 145
ILE A 296
LEU A 138
 None
 1.09A 1qzfE-5xmiA:
undetectable		 1qzfE-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 252
SER A 284
ARG A 288
LEU A 256
 None
 1.09A 1y0xX-5xmiA:
undetectable		 1y0xX-5xmiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 130
ALA A 187
LEU A 273
LEU A 145
ILE A 296
LEU A 138
 None
 1.45A 2oipA-5xmiA:
undetectable		 2oipA-5xmiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 182
LEU A 145
VAL A 149
ILE A 228
PHE A 194
 None
 1.25A 2weyA-5xmiA:
undetectable		 2weyA-5xmiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 171
ALA A 144
PRO A 297
ILE A 296
ILE A 294
 None
 0.89A 3ebzA-5xmiA:
undetectable		 3ebzA-5xmiA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 333
VAL A 417
ASP A 338
ILE A 339
 None
 0.92A 3fi0P-5xmiA:
undetectable		 3fi0P-5xmiA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 130
ALA A 187
LEU A 273
LEU A 145
ILE A 296
LEU A 138
 None
 1.34A 3hj3D-5xmiA:
undetectable		 3hj3D-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 228
ILE A 169
ALA A 148
VAL A 186
 None
 0.81A 4jltA-5xmiA:
undetectable		 4jltA-5xmiA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 130
ALA A 187
LEU A 273
LEU A 145
ILE A 296
LEU A 138
 None
 1.45A 4ky8A-5xmiA:
undetectable		 4ky8A-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 130
ALA A 187
LEU A 273
LEU A 145
ILE A 296
LEU A 138
 None
 1.44A 4ky8B-5xmiA:
undetectable		 4ky8B-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 130
LEU A 145
LYS A 179
SER A 180
ILE A 228
 None
 1.13A 4ky8B-5xmiA:
undetectable		 4ky8B-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 130
ALA A 187
LEU A 273
LEU A 145
ILE A 296
LEU A 138
 None
 1.43A 4ky8C-5xmiA:
undetectable		 4ky8C-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 130
ALA A 187
LEU A 273
LEU A 145
ILE A 296
LEU A 138
 None
 1.46A 4ky8D-5xmiA:
undetectable		 4ky8D-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 130
ALA A 187
LEU A 273
LEU A 145
ILE A 296
LEU A 138
 None
 1.44A 4ky8E-5xmiA:
undetectable		 4ky8E-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 186
LEU A 273
GLY A 140
ALA A 141
LEU A 145
 None
 1.10A 4ph9A-5xmiA:
undetectable		 4ph9A-5xmiA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 186
LEU A 273
GLY A 140
ALA A 141
LEU A 145
 None
 1.10A 4ph9B-5xmiA:
undetectable		 4ph9B-5xmiA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 130
ALA A 187
LEU A 273
LEU A 145
ILE A 296
LEU A 138
 None
 1.45A 4q0dA-5xmiA:
undetectable		 4q0dA-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 130
LEU A 145
LYS A 179
SER A 180
ILE A 228
 None
 1.17A 4q0dA-5xmiA:
undetectable		 4q0dA-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 130
ALA A 187
LEU A 273
LEU A 145
ILE A 296
LEU A 138
 None
 1.45A 4q0dB-5xmiA:
undetectable		 4q0dB-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 130
LEU A 145
LYS A 179
SER A 180
ILE A 228
 None
 1.17A 4q0dB-5xmiA:
undetectable		 4q0dB-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 130
ALA A 187
LEU A 273
LEU A 145
ILE A 296
LEU A 138
 None
 1.45A 4q0dE-5xmiA:
undetectable		 4q0dE-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 130
LEU A 145
LYS A 179
SER A 180
ILE A 228
 None
 1.17A 4q0dE-5xmiA:
undetectable		 4q0dE-5xmiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		3 / 3 THR A 374
PRO A 399
ASP A 405
 None
 0.89A 5l8dB-5xmiA:
undetectable		 5l8dB-5xmiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		3 / 3 THR A 374
PRO A 399
ASP A 405
 None
 0.89A 5mwuB-5xmiA:
undetectable		 5mwuB-5xmiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 11 SER A 335
GLY A 173
LEU A 170
ASP A 283
ASP A 232
 None
 1.25A 6i5zD-5xmiA:
undetectable		 6i5zD-5xmiA:
24.61