SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xmj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 GLU A 572
ASP A 187
LEU A 386
LEU A 245
GLY A 244
 None
 1.39A 1d4fA-5xmjA:
2.0		 1d4fA-5xmjA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 GLU A 572
ASP A 187
LEU A 386
LEU A 245
GLY A 244
 None
 1.35A 1d4fB-5xmjA:
2.1		 1d4fB-5xmjA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5xmj SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Desulfovibrio
gigas) 		4 / 8 GLU B  87
ASN B  70
ALA B  39
LEU B  40
 None
 0.69A 1hwiB-5xmjB:
undetectable		 1hwiB-5xmjB:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 5xmj SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Desulfovibrio
gigas) 		4 / 8 GLU B  87
ASN B  70
ALA B  39
LEU B  40
 None
 0.67A 1hwiC-5xmjB:
undetectable		 1hwiC-5xmjB:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 7 MET A 248
SER A 391
ALA A 383
ALA A 396
 None
 1.07A 1k5qA-5xmjA:
undetectable
1k5qB-5xmjA:
undetectable		 1k5qA-5xmjA:
undetectable
1k5qB-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		3 / 3 ARG A 301
ARG A 139
ARG A 405
 FUM  A 702 (-2.9A)
None
FUM  A 702 ( 3.0A)
 1.10A 1l7fA-5xmjA:
undetectable		 1l7fA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		3 / 3 ARG A 301
ARG A 139
ARG A 405
 FUM  A 702 (-2.9A)
None
FUM  A 702 ( 3.0A)
 1.07A 1l7hA-5xmjA:
undetectable		 1l7hA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5xmj FUMARATE REDUCTASE
RESPIRATORY COMPLEX
SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 LEU B 224
CYH B 151
VAL B 217
HIS C 106
LEU C 104
 SF4  B 302 (-4.7A)
SF4  B 302 (-2.2A)
None
None
None
 1.22A 1rk3A-5xmjB:
undetectable		 1rk3A-5xmjB:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 8 ASP A 302
GLY A 142
PHE A 141
THR A 269
 None
None
FUM  A 702 (-4.3A)
FUM  A 702 (-3.4A)
 0.90A 2aouA-5xmjA:
undetectable		 2aouA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 8 ALA A 229
SER A  35
LEU A  36
VAL A  37
 None
FAD  A 701 (-3.3A)
FAD  A 701 (-3.7A)
FAD  A 701 ( 4.9A)
 0.65A 2bxgA-5xmjA:
undetectable		 2bxgA-5xmjA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 7 ASP A  91
PHE A  89
ARG A  87
ALA A  54
 None
 1.11A 2e5dA-5xmjA:
undetectable
2e5dB-5xmjA:
undetectable		 2e5dA-5xmjA:
undetectable
2e5dB-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		6 / 11 SER A 395
LEU A  15
GLY A  13
GLY A  12
LEU A 411
SER A 410
 FAD  A 701 ( 4.9A)
FAD  A 701 (-4.9A)
FAD  A 701 (-3.5A)
FAD  A 701 (-2.9A)
FAD  A 701 (-3.7A)
FAD  A 701 (-3.5A)
 1.40A 2qmmA-5xmjA:
undetectable
2qmmB-5xmjA:
undetectable		 2qmmA-5xmjA:
undetectable
2qmmB-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 8 ALA A 215
GLY A 381
SER A 395
ALA A 396
 FAD  A 701 (-4.5A)
None
FAD  A 701 ( 4.9A)
None
 0.78A 2vh3B-5xmjA:
undetectable		 2vh3B-5xmjA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Desulfovibrio
gigas) 		4 / 7 ASN B 143
GLU B 144
LEU B 148
TYR A 151
 None
 1.22A 2w8yA-5xmjB:
undetectable		 2w8yA-5xmjB:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 8 MET A  33
ALA A 215
ALA A  16
LEU A 164
 None
FAD  A 701 (-4.5A)
FAD  A 701 (-3.9A)
None
 1.03A 2wx2B-5xmjA:
undetectable		 2wx2B-5xmjA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5xmj FUMARATE REDUCTASE
RESPIRATORY COMPLEX
SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 LEU B 224
CYH B 151
VAL B 217
HIS C 106
LEU C 104
 SF4  B 302 (-4.7A)
SF4  B 302 (-2.2A)
None
None
None
 1.20A 2zlcA-5xmjB:
undetectable		 2zlcA-5xmjB:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 GLN A 297
PHE A 141
ALA A 140
GLY A 120
LEU A 333
 None
FUM  A 702 (-4.3A)
None
None
None
 1.26A 3aodC-5xmjA:
undetectable		 3aodC-5xmjA:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		3 / 3 ARG A 379
VAL A 416
THR A  92
 None
 0.76A 3cyxA-5xmjA:
undetectable		 3cyxA-5xmjA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 5xmj SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Desulfovibrio
gigas) 		6 / 11 ALA B 164
GLY B 155
SER B 175
VAL B 174
ARG B 178
ALA B 173
 None
SF4  B 302 ( 4.9A)
None
SF4  B 302 (-4.8A)
None
F3S  B 301 ( 3.9A)
 1.43A 3dcmX-5xmjB:
undetectable		 3dcmX-5xmjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 4 ILE A  11
GLN A 180
ILE A  32
LEU A 523
 FAD  A 701 (-4.7A)
FAD  A 701 (-4.8A)
None
None
 1.21A 3dzyD-5xmjA:
undetectable		 3dzyD-5xmjA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 5 ARG A 273
ILE A 330
VAL A 345
THR A 227
 None
None
None
FAD  A 701 (-4.9A)
 1.25A 3eigA-5xmjA:
undetectable		 3eigA-5xmjA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 PHE A 436
THR A 210
ILE A  11
ASP A   7
LEU A   9
 None
None
FAD  A 701 (-4.7A)
None
None
 1.28A 3iv6B-5xmjA:
2.8		 3iv6B-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 TRP A 398
GLY A 393
THR A 414
ILE A 214
ARG A  19
 None
FAD  A 701 (-3.4A)
FAD  A 701 ( 4.6A)
None
None
 1.28A 3iv6D-5xmjA:
2.8		 3iv6D-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_B_TPFB490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 9 TYR A 370
ALA A  16
ALA A 392
THR A 377
MET A 400
 FAD  A 701 ( 4.9A)
FAD  A 701 (-3.9A)
None
None
None
 1.24A 3l4dB-5xmjA:
undetectable		 3l4dB-5xmjA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 9 TYR A 370
ALA A  16
ALA A 392
THR A 377
MET A 400
 FAD  A 701 ( 4.9A)
FAD  A 701 (-3.9A)
None
None
None
 1.30A 3l4dC-5xmjA:
undetectable		 3l4dC-5xmjA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA206_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 4 ASP A 265
ARG A 365
THR A 367
ALA A 225
 None
 1.48A 3mbgA-5xmjA:
0.0		 3mbgA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 LEU A 579
ALA A 536
GLY A 538
MET A 251
ASP A 541
 None
 1.04A 3ou6A-5xmjA:
undetectable		 3ou6A-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 LEU A 579
ALA A 536
GLY A 538
MET A 251
ASP A 541
 None
 1.02A 3ou6C-5xmjA:
undetectable		 3ou6C-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 LEU A 579
ALA A 536
GLY A 538
MET A 251
ASP A 541
 None
 1.06A 3ou7A-5xmjA:
undetectable		 3ou7A-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 LEU A 579
ALA A 536
GLY A 538
MET A 251
ASP A 541
 None
 1.08A 3ou7D-5xmjA:
undetectable		 3ou7D-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5xmj FUMARATE REDUCTASE
RESPIRATORY COMPLEX
(Desulfovibrio
gigas) 		5 / 12 LEU C 165
LEU C 162
ALA C 163
ILE C 198
GLY C 199
 None
None
HEM  C 301 ( 4.0A)
None
None
 1.08A 3q95B-5xmjC:
undetectable		 3q95B-5xmjC:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 10 CYH A  10
VAL A   8
ALA A  24
ALA A  27
THR A 429
 None
 1.24A 3ucjA-5xmjA:
undetectable		 3ucjA-5xmjA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 10 CYH A  10
VAL A   8
ALA A  24
ALA A  27
THR A 429
 None
 1.22A 3ucjB-5xmjA:
undetectable		 3ucjB-5xmjA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 9 THR A 535
ALA A 532
ILE A 222
TYR A 223
PHE A 256
 None
 1.47A 3upwA-5xmjA:
undetectable		 3upwA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5xmj FUMARATE REDUCTASE
RESPIRATORY COMPLEX
SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 LEU B 224
CYH B 151
VAL B 217
HIS C 106
LEU C 104
 SF4  B 302 (-4.7A)
SF4  B 302 (-2.2A)
None
None
None
 1.24A 3vt3A-5xmjB:
undetectable		 3vt3A-5xmjB:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 5 SER A 300
GLN A 255
SER A 305
VAL A 304
 None
 1.35A 4a99D-5xmjA:
9.1		 4a99D-5xmjA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 5 VAL A 304
ARG A 307
MET A 308
GLU A 310
 None
 1.32A 4hojA-5xmjA:
undetectable		 4hojA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Desulfovibrio
gigas) 		4 / 6 ARG B 178
ASN A 162
GLY A  13
THR A 166
 None
None
FAD  A 701 (-3.5A)
None
 0.97A 4l1aB-5xmjB:
undetectable		 4l1aB-5xmjB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 11 LEU A 279
LEU A 328
CYH A 272
HIS A 257
VAL A 345
 None
None
None
FUM  A 702 (-3.9A)
None
 1.21A 4mk4B-5xmjA:
undetectable		 4mk4B-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 5xmj FUMARATE REDUCTASE
RESPIRATORY COMPLEX
SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Desulfovibrio
gigas) 		3 / 3 SER B 191
ASP B 193
GLN C  12
 None
 0.96A 4oltA-5xmjB:
undetectable
4oltB-5xmjB:
undetectable		 4oltA-5xmjB:
14.11
4oltB-5xmjB:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 ARG A 109
ILE A 136
TYR A 117
TYR A 151
HIS A 115
 None
 1.44A 4qe6A-5xmjA:
undetectable		 4qe6A-5xmjA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 7 PRO A 592
SER A 585
ASP A 380
THR A 377
 None
 1.30A 4uacA-5xmjA:
undetectable		 4uacA-5xmjA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 9 VAL A 246
LEU A 184
THR A 212
LEU A 213
ILE A  11
 None
None
None
None
FAD  A 701 (-4.7A)
 0.99A 4ubsA-5xmjA:
undetectable		 4ubsA-5xmjA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 HIS A 257
SER A 305
GLU A 270
GLY A 142
GLY A 277
 FUM  A 702 (-3.9A)
None
FUM  A 702 (-4.7A)
None
None
 1.49A 4uinH-5xmjA:
undetectable
4uinL-5xmjA:
undetectable		 4uinH-5xmjA:
undetectable
4uinL-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 HIS A 257
THR A 259
GLU A 270
GLY A 142
GLY A  50
 FUM  A 702 (-3.9A)
None
FUM  A 702 (-4.7A)
None
FAD  A 701 (-4.8A)
 1.47A 4uinH-5xmjA:
undetectable
4uinL-5xmjA:
undetectable		 4uinH-5xmjA:
undetectable
4uinL-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Desulfovibrio
gigas;
Desulfovibrio
gigas) 		5 / 11 SER B  64
SER A  35
ASP B 105
THR B 106
GLY B 107
 None
FAD  A 701 (-3.3A)
None
None
None
 1.35A 4zjoD-5xmjB:
undetectable		 4zjoD-5xmjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 8 GLU A 394
SER A 410
ARG A 405
GLY A 408
 FAD  A 701 (-4.2A)
FAD  A 701 (-3.5A)
FUM  A 702 ( 3.0A)
FAD  A 701 ( 3.4A)
 0.76A 5e26C-5xmjA:
undetectable
5e26D-5xmjA:
undetectable		 5e26C-5xmjA:
undetectable
5e26D-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 8 GLU A 292
GLY A 599
GLY A 600
VAL A 303
 None
 0.74A 5f8yA-5xmjA:
undetectable		 5f8yA-5xmjA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 8 GLU A 292
GLY A 599
GLY A 600
VAL A 303
 None
 0.76A 5f8yB-5xmjA:
undetectable		 5f8yB-5xmjA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 MET A 248
LEU A 245
LEU A 184
ILE A 238
GLY A 235
 None
None
None
None
FAD  A 701 (-3.5A)
 1.07A 5gtrA-5xmjA:
undetectable		 5gtrA-5xmjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		3 / 3 ILE A  88
MET A 590
ASP A  82
 None
 0.77A 5h2uA-5xmjA:
undetectable		 5h2uA-5xmjA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 SER A 545
LEU A 579
GLY A 538
ALA A 539
LEU A 489
 None
 1.12A 5iktA-5xmjA:
undetectable		 5iktA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 GLU A 582
LEU A 579
GLY A 249
ASN A 250
ALA A 539
 None
 1.34A 5kbwA-5xmjA:
undetectable		 5kbwA-5xmjA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 GLU A 582
LEU A 579
GLY A 249
ASN A 250
ALA A 539
 None
 1.40A 5kbwB-5xmjA:
undetectable		 5kbwB-5xmjA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 GLU A 582
LEU A 579
GLY A 249
ASN A 250
ALA A 539
 None
 1.38A 5kc0A-5xmjA:
undetectable		 5kc0A-5xmjA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 GLU A 582
LEU A 579
GLY A 249
MET A 251
ASN A 250
 None
 1.38A 5kc0A-5xmjA:
undetectable		 5kc0A-5xmjA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 5 GLU A 394
SER A 410
ARG A 405
GLY A 408
 FAD  A 701 (-4.2A)
FAD  A 701 (-3.5A)
FUM  A 702 ( 3.0A)
FAD  A 701 ( 3.4A)
 0.85A 5kprA-5xmjA:
undetectable		 5kprA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 8 ARG A 306
ARG A 484
TYR A 223
THR A 535
 None
 1.36A 5l8dA-5xmjA:
1.9		 5l8dA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 8 ARG A 306
ARG A 484
TYR A 223
THR A 535
 None
 1.36A 5mwuA-5xmjA:
1.9		 5mwuA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		3 / 3 GLY A 189
LEU A 386
HIS A 186
 None
 0.66A 5u63A-5xmjA:
14.5		 5u63A-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		3 / 3 GLY A 189
LEU A 386
HIS A 186
 None
 0.62A 5u63B-5xmjA:
14.6		 5u63B-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 6 THR A 350
ASN A 356
ILE A 338
GLU A 335
 None
 1.15A 5uigA-5xmjA:
3.2		 5uigA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 4 GLU A 270
THR A 269
THR A 152
LEU A 411
 FUM  A 702 (-4.7A)
FUM  A 702 (-3.4A)
None
FAD  A 701 (-3.7A)
 1.40A 5v96A-5xmjA:
2.1		 5v96A-5xmjA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 4 GLU A 270
THR A 269
THR A 152
LEU A 411
 FUM  A 702 (-4.7A)
FUM  A 702 (-3.4A)
None
FAD  A 701 (-3.7A)
 1.39A 5v96B-5xmjA:
undetectable		 5v96B-5xmjA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 4 GLU A 270
THR A 269
THR A 152
LEU A 411
 FUM  A 702 (-4.7A)
FUM  A 702 (-3.4A)
None
FAD  A 701 (-3.7A)
 1.41A 5v96C-5xmjA:
2.0		 5v96C-5xmjA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 4 GLU A 270
THR A 269
THR A 152
LEU A 411
 FUM  A 702 (-4.7A)
FUM  A 702 (-3.4A)
None
FAD  A 701 (-3.7A)
 1.41A 5v96D-5xmjA:
undetectable		 5v96D-5xmjA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 VAL A 173
GLY A  17
GLY A  13
VAL A 175
ALA A 392
 None
None
FAD  A 701 (-3.5A)
None
None
 1.15A 5x7fA-5xmjA:
undetectable		 5x7fA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5xmj SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 MET B 177
GLY B 172
ILE B 222
LEU B 224
PRO B 219
 None
None
SF4  B 302 (-4.6A)
SF4  B 302 (-4.7A)
SF4  B 302 (-4.5A)
 1.16A 6b3aA-5xmjB:
undetectable		 6b3aA-5xmjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5xmj SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 MET B 177
GLY B 172
ILE B 222
LEU B 224
PRO B 219
 None
None
SF4  B 302 (-4.6A)
SF4  B 302 (-4.7A)
SF4  B 302 (-4.5A)
 1.14A 6b3bA-5xmjB:
undetectable		 6b3bA-5xmjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		3 / 3 HIS A 257
HIS A 369
ARG A 405
 FUM  A 702 (-3.9A)
FUM  A 702 ( 3.4A)
FUM  A 702 ( 3.0A)
 0.86A 6b58A-5xmjA:
53.8		 6b58A-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 ASP A 233
GLY A 234
GLY A  13
GLY A  12
ILE A  11
 FAD  A 701 ( 4.3A)
None
FAD  A 701 (-3.5A)
FAD  A 701 (-2.9A)
FAD  A 701 (-4.7A)
 0.77A 6dj1A-5xmjA:
undetectable		 6dj1A-5xmjA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 10 GLY A  13
GLY A  17
SER A  35
VAL A 175
CYH A  10
 FAD  A 701 (-3.5A)
None
FAD  A 701 (-3.3A)
None
None
 0.83A 6exiA-5xmjA:
2.0		 6exiA-5xmjA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 10 GLY A  13
GLY A  17
SER A  35
VAL A 175
CYH A  10
 FAD  A 701 (-3.5A)
None
FAD  A 701 (-3.3A)
None
None
 0.82A 6exiB-5xmjA:
undetectable		 6exiB-5xmjA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 GLY A  13
GLY A  17
SER A  35
VAL A 175
CYH A  10
 FAD  A 701 (-3.5A)
None
FAD  A 701 (-3.3A)
None
None
 0.81A 6exiC-5xmjA:
2.1
6exiD-5xmjA:
2.2		 6exiC-5xmjA:
23.17
6exiD-5xmjA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 GLY A  13
GLY A  17
SER A  35
VAL A 175
CYH A  10
 FAD  A 701 (-3.5A)
None
FAD  A 701 (-3.3A)
None
None
 0.83A 6exiC-5xmjA:
2.1
6exiD-5xmjA:
2.2		 6exiC-5xmjA:
23.17
6exiD-5xmjA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		4 / 7 THR A 259
ARG A 331
HIS A 359
ASP A 329
 None
 1.28A 6mn4E-5xmjA:
undetectable		 6mn4E-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Desulfovibrio
gigas) 		5 / 12 LEU A 199
LEU A  36
ILE A 239
ALA A 181
ASP A 233
 None
FAD  A 701 (-3.7A)
None
FAD  A 701 (-3.7A)
FAD  A 701 ( 4.3A)
 1.16A 6n91B-5xmjA:
undetectable		 6n91B-5xmjA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 5xmj SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT
(Desulfovibrio
gigas) 		3 / 3 ILE B  88
THR B  89
PRO B  85
 None
 0.64A 6ncsA-5xmjB:
undetectable		 6ncsA-5xmjB:
undetectable