SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xmm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		4 / 4 THR A 179
LEU A 180
VAL A  29
LEU A   6
 None
 1.07A 1fbmB-5xmmA:
undetectable		 1fbmB-5xmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 5xmm BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		4 / 4 GLY B  30
ASP B  59
GLY A 121
THR A  11
 None
 1.09A 1hxbB-5xmmB:
undetectable		 1hxbB-5xmmB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		3 / 3 ASP A 117
PHE A  75
ARG A  98
 None
 0.89A 2a3aA-5xmmA:
undetectable		 2a3aA-5xmmA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2436_1
(CHITINASE)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		4 / 4 TRP A 148
ASP A 117
PHE A  75
ARG A  98
 None
 1.34A 2a3aB-5xmmA:
0.0		 2a3aB-5xmmA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		4 / 6 TRP A 148
ASP A 117
PHE A  75
ARG A  98
 None
 1.34A 2a3bB-5xmmA:
undetectable		 2a3bB-5xmmA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 5xmm BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		4 / 8 SER A  93
VAL A  13
PRO B  33
HIS B  32
 None
 1.03A 2ddwA-5xmmA:
undetectable		 2ddwA-5xmmA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
BETA-2-MICROGLOBULIN
(Felis
catus;
Felis
catus) 		3 / 3 SER A  93
THR B  86
GLN B   3
 None
 0.79A 2fk8A-5xmmA:
undetectable		 2fk8A-5xmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		4 / 8 ARG A  49
SER A 168
VAL A  68
VAL A  35
 None
 1.10A 2y05A-5xmmA:
undetectable
2y05B-5xmmA:
undetectable		 2y05A-5xmmA:
13.18
2y05B-5xmmA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		4 / 7 MET A 175
LEU A 173
PHE A  34
VAL A  35
 None
 1.14A 3jwqC-5xmmA:
undetectable		 3jwqC-5xmmA:
12.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		6 / 10 TYR A  10
ILE A  96
TYR A 100
TYR A 124
ILE A 125
TRP A 148
 None
 0.47A 3uprA-5xmmA:
33.7		 3uprA-5xmmA:
37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		6 / 10 TYR A  10
ILE A  96
TYR A 100
TYR A 124
ILE A 125
TRP A 148
 None
 0.42A 3uprC-5xmmA:
33.8		 3uprC-5xmmA:
37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		5 / 10 TYR A  10
TYR A 100
TYR A 124
ILE A 125
TRP A 148
 None
 0.28A 3vriA-5xmmA:
34.3
3vriC-5xmmA:
undetectable		 3vriA-5xmmA:
37.08
3vriC-5xmmA:
6.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		6 / 12 TYR A  10
ILE A  96
TYR A 100
TYR A 124
ILE A 125
TRP A 148
 None
 0.39A 3vrjA-5xmmA:
34.3
3vrjC-5xmmA:
undetectable		 3vrjA-5xmmA:
37.08
3vrjC-5xmmA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		5 / 12 THR A 188
LEU A 207
ALA A 206
GLY A 266
LEU A 267
 None
 1.07A 5gs4A-5xmmA:
undetectable		 5gs4A-5xmmA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		3 / 3 PRO A  48
ARG A  49
GLU A  54
 None
 0.91A 5j6hA-5xmmA:
33.4		 5j6hA-5xmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
BETA-2-MICROGLOBULIN
(Felis
catus;
Felis
catus) 		5 / 12 TYR B  63
ILE A 214
PHE A 209
LEU A 231
GLU A 233
 None
 1.15A 5l8oB-5xmmB:
undetectable		 5l8oB-5xmmB:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		6 / 10 TYR A  10
ILE A  96
TYR A 100
TYR A 124
ILE A 125
TRP A 148
 None
 0.43A 5u98A-5xmmA:
34.1		 5u98A-5xmmA:
37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		6 / 10 TYR A  10
ILE A  96
TYR A 100
TYR A 124
ILE A 125
TRP A 148
 None
 0.40A 5u98D-5xmmA:
34.0		 5u98D-5xmmA:
37.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		4 / 7 PHE A  37
ARG A  36
ALA A  72
GLN A  73
 None
 1.22A 6b89A-5xmmA:
undetectable		 6b89A-5xmmA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		4 / 7 ALA A  12
THR A  11
TYR A  10
PRO A  44
 None
 0.95A 6cduA-5xmmA:
2.9
6cduE-5xmmA:
undetectable		 6cduA-5xmmA:
undetectable
6cduE-5xmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
(Felis
catus) 		4 / 7 PRO A  44
ALA A  12
THR A  11
TYR A  10
 None
 0.95A 6cduH-5xmmA:
undetectable
6cduI-5xmmA:
3.0		 6cduH-5xmmA:
undetectable
6cduI-5xmmA:
undetectable