SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xmr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_A_FFOA1002_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	7 / 12	LEU A 124 GLY A 127 HIS A 129 LEU A 130 VAL A 141 ASN A 356 ARG A 371	8AO A 502 (-4.3A) 8AO A 502 ( 4.1A) PLG A 501 ( 3.5A) 8AO A 502 (-4.3A) 8AO A 502 (-4.0A) 8AO A 502 (-3.2A) PLG A 501 (-3.1A)	0.66A	1dfoA-5xmrA: 53.7	1dfoA-5xmrA: 40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_A_FFOA1002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 5	GLU A 56 TYR A 63 TYR A 64 PHE A 266 PRO A 267	None	0.63A	1dfoB-5xmrA: 56.4	1dfoB-5xmrA: 40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_B_FFOB2002_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 5	GLU A 56 TYR A 63 TYR A 64 PHE A 266 PRO A 267	None	0.63A	1dfoA-5xmrA: 53.7	1dfoA-5xmrA: 40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_B_FFOB2002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	7 / 12	LEU A 124 GLY A 127 HIS A 129 LEU A 130 VAL A 141 ASN A 356 ARG A 371	8AO A 502 (-4.3A) 8AO A 502 ( 4.1A) PLG A 501 ( 3.5A) 8AO A 502 (-4.3A) 8AO A 502 (-4.0A) 8AO A 502 (-3.2A) PLG A 501 (-3.1A)	0.66A	1dfoB-5xmrA: 56.4	1dfoB-5xmrA: 40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_C_FFOC3002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	7 / 12	LEU A 124 GLY A 127 HIS A 129 LEU A 130 VAL A 141 ASN A 356 ARG A 371	8AO A 502 (-4.3A) 8AO A 502 ( 4.1A) PLG A 501 ( 3.5A) 8AO A 502 (-4.3A) 8AO A 502 (-4.0A) 8AO A 502 (-3.2A) PLG A 501 (-3.1A)	0.66A	1dfoC-5xmrA: 56.3	1dfoC-5xmrA: 40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_C_FFOC3002_2 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 5	GLU A 56 TYR A 63 TYR A 64 PHE A 266 PRO A 267	None	0.63A	1dfoD-5xmrA: 53.8	1dfoD-5xmrA: 40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_D_FFOD4002_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 5	GLU A 56 TYR A 63 TYR A 64 PHE A 266 PRO A 267	None	0.63A	1dfoC-5xmrA: 56.3	1dfoC-5xmrA: 40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_D_FFOD4002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	7 / 12	LEU A 124 GLY A 127 HIS A 129 LEU A 130 VAL A 141 ASN A 356 ARG A 371	8AO A 502 (-4.3A) 8AO A 502 ( 4.1A) PLG A 501 ( 3.5A) 8AO A 502 (-4.3A) 8AO A 502 (-4.0A) 8AO A 502 (-3.2A) PLG A 501 (-3.1A)	0.66A	1dfoD-5xmrA: 53.8	1dfoD-5xmrA: 40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_A_FFOA1293_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	7 / 12	LEU A 124 GLY A 127 HIS A 129 LEU A 130 VAL A 141 ASN A 356 ARG A 371	8AO A 502 (-4.3A) 8AO A 502 ( 4.1A) PLG A 501 ( 3.5A) 8AO A 502 (-4.3A) 8AO A 502 (-4.0A) 8AO A 502 (-3.2A) PLG A 501 (-3.1A)	0.65A	1eqbA-5xmrA: 53.6	1eqbA-5xmrA: 40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_A_FFOA1293_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	3 / 3	GLU A 56 TYR A 63 PHE A 266	None	0.31A	1eqbB-5xmrA: 56.1	1eqbB-5xmrA: 40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_A_GLYA1292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 8	SER A 34 HIS A 129 HIS A 211 LYS A 237 ARG A 371	PLG A 501 (-2.4A) PLG A 501 ( 3.5A) PLG A 501 (-3.8A) PLG A 501 (-3.4A) PLG A 501 (-3.1A)	0.25A	1eqbA-5xmrA: 53.6 1eqbB-5xmrA: 56.1	1eqbA-5xmrA: 40.55 1eqbB-5xmrA: 40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_B_FFOB2293_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	3 / 3	GLU A 56 TYR A 63 PHE A 266	None	0.29A	1eqbA-5xmrA: 53.6	1eqbA-5xmrA: 40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_B_FFOB2293_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	7 / 12	LEU A 124 GLY A 127 HIS A 129 LEU A 130 VAL A 141 ASN A 356 ARG A 371	8AO A 502 (-4.3A) 8AO A 502 ( 4.1A) PLG A 501 ( 3.5A) 8AO A 502 (-4.3A) 8AO A 502 (-4.0A) 8AO A 502 (-3.2A) PLG A 501 (-3.1A)	0.65A	1eqbB-5xmrA: 56.1	1eqbB-5xmrA: 40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_B_GLYB2292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 8	SER A 34 HIS A 129 HIS A 211 LYS A 237 ARG A 371	PLG A 501 (-2.4A) PLG A 501 ( 3.5A) PLG A 501 (-3.8A) PLG A 501 (-3.4A) PLG A 501 (-3.1A)	0.25A	1eqbA-5xmrA: 53.6 1eqbB-5xmrA: 56.1	1eqbA-5xmrA: 40.55 1eqbB-5xmrA: 40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_C_FFOC3293_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	7 / 12	LEU A 124 GLY A 127 HIS A 129 LEU A 130 VAL A 141 ASN A 356 ARG A 371	8AO A 502 (-4.3A) 8AO A 502 ( 4.1A) PLG A 501 ( 3.5A) 8AO A 502 (-4.3A) 8AO A 502 (-4.0A) 8AO A 502 (-3.2A) PLG A 501 (-3.1A)	0.65A	1eqbC-5xmrA: 56.1	1eqbC-5xmrA: 40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_C_FFOC3293_2 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	3 / 3	GLU A 56 TYR A 63 PHE A 266	None	0.31A	1eqbD-5xmrA: 56.8	1eqbD-5xmrA: 40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_C_GLYC3292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 8	SER A 34 HIS A 129 HIS A 211 LYS A 237 ARG A 371	PLG A 501 (-2.4A) PLG A 501 ( 3.5A) PLG A 501 (-3.8A) PLG A 501 (-3.4A) PLG A 501 (-3.1A)	0.25A	1eqbC-5xmrA: 56.1 1eqbD-5xmrA: 56.8	1eqbC-5xmrA: 40.55 1eqbD-5xmrA: 40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_D_FFOD4293_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	3 / 3	GLU A 56 TYR A 63 PHE A 266	None	0.31A	1eqbC-5xmrA: 56.1	1eqbC-5xmrA: 40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_D_FFOD4293_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	7 / 12	LEU A 124 GLY A 127 HIS A 129 LEU A 130 VAL A 141 ASN A 356 ARG A 371	8AO A 502 (-4.3A) 8AO A 502 ( 4.1A) PLG A 501 ( 3.5A) 8AO A 502 (-4.3A) 8AO A 502 (-4.0A) 8AO A 502 (-3.2A) PLG A 501 (-3.1A)	0.65A	1eqbD-5xmrA: 56.8	1eqbD-5xmrA: 40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_D_GLYD4292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 8	SER A 34 HIS A 129 HIS A 211 LYS A 237 ARG A 371	PLG A 501 (-2.4A) PLG A 501 ( 3.5A) PLG A 501 (-3.8A) PLG A 501 (-3.4A) PLG A 501 (-3.1A)	0.25A	1eqbC-5xmrA: 56.1 1eqbD-5xmrA: 56.8	1eqbC-5xmrA: 40.55 1eqbD-5xmrA: 40.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRL_F_TFPF211_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	4 / 7	LEU A 246 PHE A 248 LEU A 285 PHE A 225	None	1.00A	1wrlE-5xmrA: undetectable 1wrlF-5xmrA: undetectable	1wrlE-5xmrA: 10.86 1wrlF-5xmrA: 10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOT_A_VDNA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 12	LEU A 109 ILE A 247 SER A 213 PHE A 206 ILE A 179	None	0.89A	1xotA-5xmrA: undetectable	1xotA-5xmrA: 20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JJP_A_KLNA413_1 (CYTOCHROME P450 113A1)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 12	PRO A 359 ALA A 391 LEU A 394 ALA A 395 PHE A 335	None	1.21A	2jjpA-5xmrA: undetectable	2jjpA-5xmrA: 22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNI_A_MTKA501_1 (CYTOCHROME P450 2C8)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 12	SER A 55 THR A 233 VAL A 281 ALA A 280 VAL A 50	None	1.28A	2nniA-5xmrA: undetectable	2nniA-5xmrA: 22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_A_FFOA505_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 6	GLU A 56 TYR A 63 TYR A 64 PHE A 266 PRO A 267	None	0.65A	2vmyA-5xmrA: 57.2	2vmyA-5xmrA: 41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_A_FFOA505_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	7 / 12	LEU A 124 GLY A 127 HIS A 129 LEU A 130 VAL A 141 ASN A 356 ARG A 371	8AO A 502 (-4.3A) 8AO A 502 ( 4.1A) PLG A 501 ( 3.5A) 8AO A 502 (-4.3A) 8AO A 502 (-4.0A) 8AO A 502 (-3.2A) PLG A 501 (-3.1A)	0.73A	2vmyB-5xmrA: 57.3	2vmyB-5xmrA: 41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_A_GLYA502_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 7	SER A 34 HIS A 129 HIS A 211 LYS A 237 ARG A 371	PLG A 501 (-2.4A) PLG A 501 ( 3.5A) PLG A 501 (-3.8A) PLG A 501 (-3.4A) PLG A 501 (-3.1A)	0.40A	2vmyA-5xmrA: 57.2 2vmyB-5xmrA: 57.3	2vmyA-5xmrA: 41.94 2vmyB-5xmrA: 41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_B_FFOB505_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	4 / 4	GLU A 56 TYR A 63 TYR A 64 PHE A 266	None	0.76A	2vmyB-5xmrA: 57.3	2vmyB-5xmrA: 41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_B_GLYB502_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 8	SER A 34 HIS A 129 HIS A 211 LYS A 237 ARG A 371	PLG A 501 (-2.4A) PLG A 501 ( 3.5A) PLG A 501 (-3.8A) PLG A 501 (-3.4A) PLG A 501 (-3.1A)	0.30A	2vmyA-5xmrA: 57.2 2vmyB-5xmrA: 57.3	2vmyA-5xmrA: 41.94 2vmyB-5xmrA: 41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W9S_F_TOPF1159_1 (DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 10	ILE A 337 LEU A 353 LEU A 394 ILE A 398 THR A 345	None	1.13A	2w9sF-5xmrA: undetectable	2w9sF-5xmrA: 17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LW5_B_PQNB5002_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 10	ILE A 238 ARG A 80 ALA A 282 LEU A 285 ALA A 81	None	1.26A	3lw5B-5xmrA: undetectable	3lw5B-5xmrA: 20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W67_D_VIVD301_0 (ALPHA-TOCOPHEROL TRANSFER PROTEIN)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 12	VAL A 96 SER A 244 LEU A 99 ILE A 73 LEU A 46	None	1.15A	3w67D-5xmrA: undetectable	3w67D-5xmrA: 20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G1B_D_ECND403_1 (FLAVOHEMOGLOBIN)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 12	ILE A 257 PHE A 269 THR A 232 LEU A 112 ILE A 179	None	0.97A	4g1bD-5xmrA: undetectable	4g1bD-5xmrA: 22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 12	LEU A 353 VAL A 370 PHE A 335 LEU A 412 THR A 401	None	1.20A	4iaqA-5xmrA: undetectable	4iaqA-5xmrA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K0B_B_SAMB504_1 (S-ADENOSYLMETHIONINE SYNTHASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	4 / 8	HIS A 129 ASP A 208 ALA A 104 SER A 210	PLG A 501 ( 3.5A) PLG A 501 (-3.1A) None PLG A 501 (-3.5A)	1.02A	4k0bB-5xmrA: undetectable	4k0bB-5xmrA: 25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L7I_B_SAMB501_1 (S-ADENOSYLMETHIONINE SYNTHASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	4 / 8	HIS A 129 ASP A 208 ALA A 104 SER A 210	PLG A 501 ( 3.5A) PLG A 501 (-3.1A) None PLG A 501 (-3.5A)	1.01A	4l7iB-5xmrA: undetectable	4l7iB-5xmrA: 25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XJ7_A_ADNA303_1 (5'/3'-NUCLEOTIDASE SURE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 10	GLY A 369 ASN A 354 ALA A 397 ILE A 337 LEU A 332	None 8AO A 502 ( 4.4A) None None None	1.23A	4xj7A-5xmrA: undetectable 4xj7B-5xmrA: undetectable	4xj7A-5xmrA: 21.49 4xj7B-5xmrA: 21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DB5_A_CYSA503_0 (CYSTEINE DESULFURASE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	4 / 8	HIS A 129 ARG A 371 HIS A 236 THR A 234	PLG A 501 ( 3.5A) PLG A 501 (-3.1A) PLG A 501 (-4.1A) PLG A 501 ( 4.7A)	1.31A	5db5A-5xmrA: 29.3 5db5B-5xmrA: 28.1	5db5A-5xmrA: 21.82 5db5B-5xmrA: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FPD_A_PZAA1385_0 (HEAT SHOCK-RELATED 70KDA PROTEIN 2)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	4 / 7	ASN A 356 SER A 184 GLY A 159 VAL A 319	8AO A 502 (-3.2A) 8AO A 502 (-3.3A) None None	0.92A	5fpdA-5xmrA: undetectable	5fpdA-5xmrA: 23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5H4D_A_BBIA403_1 (NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	4 / 6	GLU A 258 PHE A 249 GLU A 74 VAL A 96	None	1.36A	5h4dA-5xmrA: undetectable	5h4dA-5xmrA: 20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M24_A_9CRA501_1 (RETINOIC ACID RECEPTOR GAMMA)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	5 / 12	ALA A 397 LEU A 342 ILE A 337 PHE A 415 ILE A 349	None	1.07A	5m24A-5xmrA: undetectable	5m24A-5xmrA: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F32_B_ACTB602_0 (AMINE OXIDASE LKCE)	5xmr	SERINE HYDROXYMETHYLTRANSFE RASE (Plasmodium vivax)	4 / 6	ASN A 156 TYR A 160 VAL A 319 THR A 320	None	1.35A	6f32B-5xmrA: undetectable	6f32B-5xmrA: 22.02

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DFO_A_FFOA1002_0","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",7,"LEU A 124;GLY A 127;HIS A 129;LEU A 130;VAL A 141;ASN A 356;ARG A 371","8AO A 502 (-4.3A);8AO A 502 ( 4.1A);PLG A 501 ( 3.5A);8AO A 502 (-4.3A);8AO A 502 (-4.0A);8AO A 502 (-3.2A);PLG A 501 (-3.1A)","0.66A","1dfoA-5xmrA:53.7","1dfoA-5xmrA:40.77"],["1DFO_A_FFOA1002_1","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"GLU A  56;TYR A  63;TYR A  64;PHE A 266;PRO A 267","None","0.63A","1dfoB-5xmrA:56.4","1dfoB-5xmrA:40.77"],["1DFO_B_FFOB2002_0","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"GLU A  56;TYR A  63;TYR A  64;PHE A 266;PRO A 267","None","0.63A","1dfoA-5xmrA:53.7","1dfoA-5xmrA:40.77"],["1DFO_B_FFOB2002_1","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",7,"LEU A 124;GLY A 127;HIS A 129;LEU A 130;VAL A 141;ASN A 356;ARG A 371","8AO A 502 (-4.3A);8AO A 502 ( 4.1A);PLG A 501 ( 3.5A);8AO A 502 (-4.3A);8AO A 502 (-4.0A);8AO A 502 (-3.2A);PLG A 501 (-3.1A)","0.66A","1dfoB-5xmrA:56.4","1dfoB-5xmrA:40.77"],["1DFO_C_FFOC3002_1","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",7,"LEU A 124;GLY A 127;HIS A 129;LEU A 130;VAL A 141;ASN A 356;ARG A 371","8AO A 502 (-4.3A);8AO A 502 ( 4.1A);PLG A 501 ( 3.5A);8AO A 502 (-4.3A);8AO A 502 (-4.0A);8AO A 502 (-3.2A);PLG A 501 (-3.1A)","0.66A","1dfoC-5xmrA:56.3","1dfoC-5xmrA:40.77"],["1DFO_C_FFOC3002_2","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"GLU A  56;TYR A  63;TYR A  64;PHE A 266;PRO A 267","None","0.63A","1dfoD-5xmrA:53.8","1dfoD-5xmrA:40.77"],["1DFO_D_FFOD4002_0","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"GLU A  56;TYR A  63;TYR A  64;PHE A 266;PRO A 267","None","0.63A","1dfoC-5xmrA:56.3","1dfoC-5xmrA:40.77"],["1DFO_D_FFOD4002_1","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",7,"LEU A 124;GLY A 127;HIS A 129;LEU A 130;VAL A 141;ASN A 356;ARG A 371","8AO A 502 (-4.3A);8AO A 502 ( 4.1A);PLG A 501 ( 3.5A);8AO A 502 (-4.3A);8AO A 502 (-4.0A);8AO A 502 (-3.2A);PLG A 501 (-3.1A)","0.66A","1dfoD-5xmrA:53.8","1dfoD-5xmrA:40.77"],["1EQB_A_FFOA1293_0","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",7,"LEU A 124;GLY A 127;HIS A 129;LEU A 130;VAL A 141;ASN A 356;ARG A 371","8AO A 502 (-4.3A);8AO A 502 ( 4.1A);PLG A 501 ( 3.5A);8AO A 502 (-4.3A);8AO A 502 (-4.0A);8AO A 502 (-3.2A);PLG A 501 (-3.1A)","0.65A","1eqbA-5xmrA:53.6","1eqbA-5xmrA:40.55"],["1EQB_A_FFOA1293_1","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",3,"GLU A  56;TYR A  63;PHE A 266","None","0.31A","1eqbB-5xmrA:56.1","1eqbB-5xmrA:40.55"],["1EQB_A_GLYA1292_0","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"SER A  34;HIS A 129;HIS A 211;LYS A 237;ARG A 371","PLG A 501 (-2.4A);PLG A 501 ( 3.5A);PLG A 501 (-3.8A);PLG A 501 (-3.4A);PLG A 501 (-3.1A)","0.25A","1eqbA-5xmrA:53.6;1eqbB-5xmrA:56.1","1eqbA-5xmrA:40.55;1eqbB-5xmrA:40.55"],["1EQB_B_FFOB2293_0","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",3,"GLU A  56;TYR A  63;PHE A 266","None","0.29A","1eqbA-5xmrA:53.6","1eqbA-5xmrA:40.55"],["1EQB_B_FFOB2293_1","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",7,"LEU A 124;GLY A 127;HIS A 129;LEU A 130;VAL A 141;ASN A 356;ARG A 371","8AO A 502 (-4.3A);8AO A 502 ( 4.1A);PLG A 501 ( 3.5A);8AO A 502 (-4.3A);8AO A 502 (-4.0A);8AO A 502 (-3.2A);PLG A 501 (-3.1A)","0.65A","1eqbB-5xmrA:56.1","1eqbB-5xmrA:40.55"],["1EQB_B_GLYB2292_0","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"SER A  34;HIS A 129;HIS A 211;LYS A 237;ARG A 371","PLG A 501 (-2.4A);PLG A 501 ( 3.5A);PLG A 501 (-3.8A);PLG A 501 (-3.4A);PLG A 501 (-3.1A)","0.25A","1eqbA-5xmrA:53.6;1eqbB-5xmrA:56.1","1eqbA-5xmrA:40.55;1eqbB-5xmrA:40.55"],["1EQB_C_FFOC3293_1","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",7,"LEU A 124;GLY A 127;HIS A 129;LEU A 130;VAL A 141;ASN A 356;ARG A 371","8AO A 502 (-4.3A);8AO A 502 ( 4.1A);PLG A 501 ( 3.5A);8AO A 502 (-4.3A);8AO A 502 (-4.0A);8AO A 502 (-3.2A);PLG A 501 (-3.1A)","0.65A","1eqbC-5xmrA:56.1","1eqbC-5xmrA:40.55"],["1EQB_C_FFOC3293_2","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",3,"GLU A  56;TYR A  63;PHE A 266","None","0.31A","1eqbD-5xmrA:56.8","1eqbD-5xmrA:40.55"],["1EQB_C_GLYC3292_0","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"SER A  34;HIS A 129;HIS A 211;LYS A 237;ARG A 371","PLG A 501 (-2.4A);PLG A 501 ( 3.5A);PLG A 501 (-3.8A);PLG A 501 (-3.4A);PLG A 501 (-3.1A)","0.25A","1eqbC-5xmrA:56.1;1eqbD-5xmrA:56.8","1eqbC-5xmrA:40.55;1eqbD-5xmrA:40.55"],["1EQB_D_FFOD4293_0","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",3,"GLU A  56;TYR A  63;PHE A 266","None","0.31A","1eqbC-5xmrA:56.1","1eqbC-5xmrA:40.55"],["1EQB_D_FFOD4293_1","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",7,"LEU A 124;GLY A 127;HIS A 129;LEU A 130;VAL A 141;ASN A 356;ARG A 371","8AO A 502 (-4.3A);8AO A 502 ( 4.1A);PLG A 501 ( 3.5A);8AO A 502 (-4.3A);8AO A 502 (-4.0A);8AO A 502 (-3.2A);PLG A 501 (-3.1A)","0.65A","1eqbD-5xmrA:56.8","1eqbD-5xmrA:40.55"],["1EQB_D_GLYD4292_0","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"SER A  34;HIS A 129;HIS A 211;LYS A 237;ARG A 371","PLG A 501 (-2.4A);PLG A 501 ( 3.5A);PLG A 501 (-3.8A);PLG A 501 (-3.4A);PLG A 501 (-3.1A)","0.25A","1eqbC-5xmrA:56.1;1eqbD-5xmrA:56.8","1eqbC-5xmrA:40.55;1eqbD-5xmrA:40.55"],["1WRL_F_TFPF211_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES;TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",4,"LEU A 246;PHE A 248;LEU A 285;PHE A 225","None","1.00A","1wrlE-5xmrA:undetectable;1wrlF-5xmrA:undetectable","1wrlE-5xmrA:10.86;1wrlF-5xmrA:10.86"],["1XOT_A_VDNA101_1","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"LEU A 109;ILE A 247;SER A 213;PHE A 206;ILE A 179","None","0.89A","1xotA-5xmrA:undetectable","1xotA-5xmrA:20.40"],["2JJP_A_KLNA413_1","CYTOCHROME P450 113A1","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"PRO A 359;ALA A 391;LEU A 394;ALA A 395;PHE A 335","None","1.21A","2jjpA-5xmrA:undetectable","2jjpA-5xmrA:22.04"],["2NNI_A_MTKA501_1","CYTOCHROME P450 2C8","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"SER A  55;THR A 233;VAL A 281;ALA A 280;VAL A  50","None","1.28A","2nniA-5xmrA:undetectable","2nniA-5xmrA:22.71"],["2VMY_A_FFOA505_0","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"GLU A  56;TYR A  63;TYR A  64;PHE A 266;PRO A 267","None","0.65A","2vmyA-5xmrA:57.2","2vmyA-5xmrA:41.94"],["2VMY_A_FFOA505_1","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",7,"LEU A 124;GLY A 127;HIS A 129;LEU A 130;VAL A 141;ASN A 356;ARG A 371","8AO A 502 (-4.3A);8AO A 502 ( 4.1A);PLG A 501 ( 3.5A);8AO A 502 (-4.3A);8AO A 502 (-4.0A);8AO A 502 (-3.2A);PLG A 501 (-3.1A)","0.73A","2vmyB-5xmrA:57.3","2vmyB-5xmrA:41.94"],["2VMY_A_GLYA502_0","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"SER A  34;HIS A 129;HIS A 211;LYS A 237;ARG A 371","PLG A 501 (-2.4A);PLG A 501 ( 3.5A);PLG A 501 (-3.8A);PLG A 501 (-3.4A);PLG A 501 (-3.1A)","0.40A","2vmyA-5xmrA:57.2;2vmyB-5xmrA:57.3","2vmyA-5xmrA:41.94;2vmyB-5xmrA:41.94"],["2VMY_B_FFOB505_1","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",4,"GLU A  56;TYR A  63;TYR A  64;PHE A 266","None","0.76A","2vmyB-5xmrA:57.3","2vmyB-5xmrA:41.94"],["2VMY_B_GLYB502_0","SERINE HYDROXYMETHYLTRANSFERASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"SER A  34;HIS A 129;HIS A 211;LYS A 237;ARG A 371","PLG A 501 (-2.4A);PLG A 501 ( 3.5A);PLG A 501 (-3.8A);PLG A 501 (-3.4A);PLG A 501 (-3.1A)","0.30A","2vmyA-5xmrA:57.2;2vmyB-5xmrA:57.3","2vmyA-5xmrA:41.94;2vmyB-5xmrA:41.94"],["2W9S_F_TOPF1159_1","DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"ILE A 337;LEU A 353;LEU A 394;ILE A 398;THR A 345","None","1.13A","2w9sF-5xmrA:undetectable","2w9sF-5xmrA:17.25"],["3LW5_B_PQNB5002_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"ILE A 238;ARG A  80;ALA A 282;LEU A 285;ALA A  81","None","1.26A","3lw5B-5xmrA:undetectable","3lw5B-5xmrA:20.19"],["3W67_D_VIVD301_0","ALPHA-TOCOPHEROL TRANSFER PROTEIN","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"VAL A  96;SER A 244;LEU A  99;ILE A  73;LEU A  46","None","1.15A","3w67D-5xmrA:undetectable","3w67D-5xmrA:20.85"],["4G1B_D_ECND403_1","FLAVOHEMOGLOBIN","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"ILE A 257;PHE A 269;THR A 232;LEU A 112;ILE A 179","None","0.97A","4g1bD-5xmrA:undetectable","4g1bD-5xmrA:22.41"],["4IAQ_A_2GMA2001_1","CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"LEU A 353;VAL A 370;PHE A 335;LEU A 412;THR A 401","None","1.20A","4iaqA-5xmrA:undetectable","4iaqA-5xmrA:21.97"],["4K0B_B_SAMB504_1","S-ADENOSYLMETHIONINE SYNTHASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",4,"HIS A 129;ASP A 208;ALA A 104;SER A 210","PLG A 501 ( 3.5A);PLG A 501 (-3.1A);None;PLG A 501 (-3.5A)","1.02A","4k0bB-5xmrA:undetectable","4k0bB-5xmrA:25.76"],["4L7I_B_SAMB501_1","S-ADENOSYLMETHIONINE SYNTHASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",4,"HIS A 129;ASP A 208;ALA A 104;SER A 210","PLG A 501 ( 3.5A);PLG A 501 (-3.1A);None;PLG A 501 (-3.5A)","1.01A","4l7iB-5xmrA:undetectable","4l7iB-5xmrA:25.76"],["4XJ7_A_ADNA303_1","5'\/3'-NUCLEOTIDASE SURE;5'\/3'-NUCLEOTIDASE SURE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"GLY A 369;ASN A 354;ALA A 397;ILE A 337;LEU A 332","None;8AO A 502 ( 4.4A);None;None;None","1.23A","4xj7A-5xmrA:undetectable;4xj7B-5xmrA:undetectable","4xj7A-5xmrA:21.49;4xj7B-5xmrA:21.49"],["5DB5_A_CYSA503_0","CYSTEINE DESULFURASE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",4,"HIS A 129;ARG A 371;HIS A 236;THR A 234","PLG A 501 ( 3.5A);PLG A 501 (-3.1A);PLG A 501 (-4.1A);PLG A 501 ( 4.7A)","1.31A","5db5A-5xmrA:29.3;5db5B-5xmrA:28.1","5db5A-5xmrA:21.82;5db5B-5xmrA:21.82"],["5FPD_A_PZAA1385_0","HEAT SHOCK-RELATED 70KDA PROTEIN 2","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",4,"ASN A 356;SER A 184;GLY A 159;VAL A 319","8AO A 502 (-3.2A);8AO A 502 (-3.3A);None;None","0.92A","5fpdA-5xmrA:undetectable","5fpdA-5xmrA:23.18"],["5H4D_A_BBIA403_1","NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",4,"GLU A 258;PHE A 249;GLU A  74;VAL A  96","None","1.36A","5h4dA-5xmrA:undetectable","5h4dA-5xmrA:20.67"],["5M24_A_9CRA501_1","RETINOIC ACID RECEPTOR GAMMA","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",5,"ALA A 397;LEU A 342;ILE A 337;PHE A 415;ILE A 349","None","1.07A","5m24A-5xmrA:undetectable","5m24A-5xmrA:20.90"],["6F32_B_ACTB602_0","AMINE OXIDASE LKCE","5xmr","SERINE HYDROXYMETHYLTRANSFERASE","Plasmodium vivax",4,"ASN A 156;TYR A 160;VAL A 319;THR A 320","None","1.35A","6f32B-5xmrA:undetectable","6f32B-5xmrA:22.02"]]