SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xn7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		3 / 3 ALA A2752
VAL A2747
TRP A2737
 None
 1.01A 1c4dA-5xn7A:
undetectable
1c4dB-5xn7A:
undetectable		 1c4dA-5xn7A:
2.10
1c4dB-5xn7A:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		3 / 3 ALA A2752
VAL A2747
TRP A2737
 None
 0.89A 1c4dC-5xn7A:
undetectable
1c4dD-5xn7A:
undetectable		 1c4dC-5xn7A:
2.10
1c4dD-5xn7A:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		4 / 7 LEU A2427
LEU A2424
SER A2420
THR A2410
 None
 1.01A 1dvxA-5xn7A:
undetectable		 1dvxA-5xn7A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		4 / 7 LEU A2427
LEU A2424
SER A2420
THR A2410
 None
 0.98A 1dvxB-5xn7A:
undetectable		 1dvxB-5xn7A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		4 / 6 PRO A2439
ASP A2498
ASN A2500
ASP A2502
 None
 1.45A 1hpkA-5xn7A:
undetectable		 1hpkA-5xn7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		3 / 3 ALA A2812
VAL A2842
TRP A2817
 None
 1.01A 1tkqA-5xn7A:
undetectable		 1tkqA-5xn7A:
2.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		5 / 9 GLY A2847
ALA A2848
LEU A2808
PHE A2871
LEU A2805
 None
 1.42A 1y7iA-5xn7A:
undetectable		 1y7iA-5xn7A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		5 / 12 LEU A2808
ALA A2811
GLY A2603
SER A2576
GLU A2572
 None
 1.29A 2a58A-5xn7A:
undetectable
2a58B-5xn7A:
undetectable		 2a58A-5xn7A:
13.15
2a58B-5xn7A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		5 / 12 LEU A2808
ALA A2811
GLY A2603
SER A2576
GLU A2572
 None
 1.30A 2a58B-5xn7A:
undetectable
2a58C-5xn7A:
undetectable		 2a58B-5xn7A:
13.15
2a58C-5xn7A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		5 / 12 LEU A2808
ALA A2811
GLY A2603
SER A2576
GLU A2572
 None
 1.29A 2a58D-5xn7A:
undetectable
2a58E-5xn7A:
undetectable		 2a58D-5xn7A:
13.15
2a58E-5xn7A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		5 / 12 LEU A2480
GLY A2433
GLU A2432
GLN A2483
ASP A2502
 None
 1.26A 3tbgA-5xn7A:
undetectable		 3tbgA-5xn7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		5 / 12 LEU A2480
GLY A2433
GLU A2432
GLN A2483
ASP A2502
 None
 1.24A 3tbgC-5xn7A:
undetectable		 3tbgC-5xn7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		3 / 3 TRP A2863
GLN A2829
THR A2838
 None
 0.98A 4m2xA-5xn7A:
undetectable		 4m2xA-5xn7A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		5 / 11 ALA A2402
LEU A2403
TYR A2406
LEU A2450
LEU A2375
 None
 0.88A 4wg0C-5xn7A:
undetectable
4wg0D-5xn7A:
undetectable
4wg0E-5xn7A:
undetectable		 4wg0C-5xn7A:
2.12
4wg0D-5xn7A:
2.12
4wg0E-5xn7A:
2.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		4 / 8 PHE A2871
ALA A2878
LEU A2875
GLY A2872
 None
 0.91A 4xk8a-5xn7A:
undetectable		 4xk8a-5xn7A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		5 / 9 LEU A2808
LEU A2851
ILE A2803
LEU A2598
ALA A2874
 None
 1.16A 5og9A-5xn7A:
undetectable		 5og9A-5xn7A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		5 / 12 LEU A2495
PHE A2544
ALA A2540
GLY A2536
TYR A2535
 None
 1.09A 5uxdB-5xn7A:
undetectable		 5uxdB-5xn7A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		5 / 7 ALA A2811
GLY A2603
GLY A2601
GLU A2572
ASN A2565
 None
 1.21A 5ybbB-5xn7A:
undetectable		 5ybbB-5xn7A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 5xn7 PUTATIVE RTX-TOXIN
(Vibrio
vulnificus) 		4 / 6 LEU A2381
ALA A2385
LEU A2427
ASN A2486
 None
 0.96A 6f88B-5xn7A:
undetectable		 6f88B-5xn7A:
9.91