SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xn8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		4 / 4 SER A 174
PHE A 245
GLU A 178
GLY A 249
 None
 1.38A 1icvA-5xn8A:
undetectable
1icvB-5xn8A:
undetectable		 1icvA-5xn8A:
21.12
1icvB-5xn8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 9 GLU A  72
ARG A  75
LEU A  76
PHE A  64
GLY A  92
 None
 1.43A 1mjlA-5xn8A:
undetectable
1mjlB-5xn8A:
undetectable		 1mjlA-5xn8A:
12.91
1mjlB-5xn8A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		4 / 5 GLY A 242
ILE A 243
VAL A 150
SER A   7
 None
 1.06A 1rs7A-5xn8A:
undetectable		 1rs7A-5xn8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		4 / 6 GLY A 242
ILE A 243
VAL A 150
SER A   7
 None
 1.04A 1rs7B-5xn8A:
undetectable		 1rs7B-5xn8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
None
None
 1.22A 1v8bA-5xn8A:
3.3		 1v8bA-5xn8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
None
None
 1.19A 1v8bB-5xn8A:
2.2		 1v8bB-5xn8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
None
None
 1.24A 1v8bD-5xn8A:
undetectable		 1v8bD-5xn8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 10 THR A 120
GLY A 272
GLY A 170
ILE A 117
LEU A 164
 None
 1.11A 1x7pA-5xn8A:
undetectable
1x7pB-5xn8A:
undetectable		 1x7pA-5xn8A:
23.10
1x7pB-5xn8A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 LEU A 305
CYH A 206
ASP A 171
ALA A 172
ALA A 236
 None
None
ZN  A 401 (-2.3A)
None
None
 1.13A 2br4A-5xn8A:
2.5		 2br4A-5xn8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 9 GLN A 361
GLY A 359
GLU A 301
ILE A 293
VAL A 284
 None
 1.29A 2drdA-5xn8A:
undetectable		 2drdA-5xn8A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 9 LEU A 173
THR A 279
GLU A 178
HIS A 254
HIS A 271
 None
None
None
ZN  A 401 (-3.4A)
ZN  A 401 ( 3.4A)
 1.41A 2jihA-5xn8A:
undetectable		 2jihA-5xn8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 11 HIS A 254
HIS A 271
ASP A 171
SER A 125
LEU A 127
 ZN  A 401 (-3.4A)
ZN  A 401 ( 3.4A)
ZN  A 401 (-2.3A)
None
None
 1.24A 2q0jB-5xn8A:
undetectable		 2q0jB-5xn8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		4 / 6 ASP A  98
VAL A 129
PRO A 123
THR A 120
 None
 1.28A 2q6oB-5xn8A:
undetectable		 2q6oB-5xn8A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		4 / 5 HIS A 257
HIS A 254
VAL A 275
HIS A 271
 None
ZN  A 401 (-3.4A)
None
ZN  A 401 ( 3.4A)
 1.04A 2wkoF-5xn8A:
undetectable		 2wkoF-5xn8A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		3 / 3 SER A 241
GLU A 178
ASP A 171
 None
None
ZN  A 401 (-2.3A)
 0.74A 2zthA-5xn8A:
3.9		 2zthA-5xn8A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		3 / 3 SER A 241
GLU A 178
ASP A 171
 None
None
ZN  A 401 (-2.3A)
 0.72A 3bwyA-5xn8A:
3.6		 3bwyA-5xn8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		4 / 5 LEU A 173
GLN A 282
THR A 279
THR A 295
 None
 1.34A 3ce6B-5xn8A:
2.1		 3ce6B-5xn8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
None
None
 1.22A 3ce6D-5xn8A:
2.4		 3ce6D-5xn8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
None
None
 1.24A 3g1uB-5xn8A:
undetectable		 3g1uB-5xn8A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
None
None
 1.22A 3g1uD-5xn8A:
3.1		 3g1uD-5xn8A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 ALA A 172
GLY A 168
LEU A 173
GLY A 242
SER A 241
 None
 0.96A 3g2oA-5xn8A:
undetectable		 3g2oA-5xn8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 ALA A 172
GLY A 168
LEU A 173
GLY A 242
SER A 241
 None
 0.97A 3g2oB-5xn8A:
undetectable		 3g2oB-5xn8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
None
None
 1.21A 3n58C-5xn8A:
3.4		 3n58C-5xn8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 SER A 288
ILE A 293
ALA A 355
ILE A 256
ALA A 252
 None
 1.18A 3nxuB-5xn8A:
undetectable		 3nxuB-5xn8A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
None
None
 1.25A 3ondA-5xn8A:
2.1		 3ondA-5xn8A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
None
None
 1.26A 3ondB-5xn8A:
2.1		 3ondB-5xn8A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		4 / 5 GLU A 294
LEU A 297
GLN A 361
GLY A 359
 None
 1.31A 3pp1A-5xn8A:
undetectable		 3pp1A-5xn8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		4 / 6 SER A 195
ILE A   5
ASP A 121
THR A 335
 None
None
ZN  A 401 ( 4.1A)
None
 1.10A 3q70A-5xn8A:
undetectable		 3q70A-5xn8A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 10 ALA A 191
LEU A 127
ALA A 122
VAL A 113
VAL A 111
 None
 1.10A 3r9cA-5xn8A:
undetectable		 3r9cA-5xn8A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 10 LEU A 127
GLY A 249
GLU A 178
GLY A 244
SER A 241
 None
 1.21A 4bwlC-5xn8A:
3.0		 4bwlC-5xn8A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 257
GLY A 278
HIS A 254
ASP A 171
GLY A 272
 None
None
ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
 1.22A 4bz6C-5xn8A:
2.9		 4bz6C-5xn8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		4 / 8 LEU A 263
ILE A 352
VAL A 348
GLY A 259
 None
 0.86A 4eq4B-5xn8A:
undetectable		 4eq4B-5xn8A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 10 ALA A  17
ILE A 114
VAL A  48
GLY A  51
VAL A 151
 None
 1.08A 4j5jB-5xn8A:
undetectable		 4j5jB-5xn8A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		4 / 8 ARG A 218
LEU A 165
ASN A 237
ILE A 234
 None
 0.97A 4k0bA-5xn8A:
undetectable		 4k0bA-5xn8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		4 / 8 ARG A 218
LEU A 165
ASN A 237
ILE A 234
 None
 1.04A 4l7iA-5xn8A:
undetectable		 4l7iA-5xn8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 257
GLY A 278
HIS A 254
ASP A 171
GLY A 272
 None
None
ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
 1.22A 4lxzC-5xn8A:
2.0		 4lxzC-5xn8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		4 / 5 GLY A 249
SER A 248
ALA A 179
PHE A 245
 None
 0.91A 4m93B-5xn8A:
undetectable
4m93C-5xn8A:
undetectable		 4m93B-5xn8A:
21.72
4m93C-5xn8A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 LEU A 309
ALA A 281
ILE A 318
ILE A 256
VAL A 325
 None
 0.94A 4nkxA-5xn8A:
undetectable		 4nkxA-5xn8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 LEU A 309
ALA A 281
ILE A 318
ILE A 256
VAL A 325
 None
 0.96A 4nkxC-5xn8A:
undetectable		 4nkxC-5xn8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 LEU A 309
ALA A 281
ILE A 318
ILE A 256
VAL A 325
 None
 0.96A 4nkxD-5xn8A:
undetectable		 4nkxD-5xn8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 ASN A 338
ALA A 191
GLY A 192
GLY A 193
ILE A   5
 None
 0.93A 4obwB-5xn8A:
undetectable		 4obwB-5xn8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 257
GLY A 278
HIS A 254
ASP A 171
GLY A 272
 None
None
ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
 1.27A 4qa0A-5xn8A:
undetectable		 4qa0A-5xn8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 257
GLY A 278
HIS A 254
ASP A 171
GLY A 272
 None
None
ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
 1.31A 4qa2A-5xn8A:
3.0		 4qa2A-5xn8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
None
None
 1.25A 5axdA-5xn8A:
undetectable		 5axdA-5xn8A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
None
None
 1.24A 5axdC-5xn8A:
undetectable		 5axdC-5xn8A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 PRO A   8
VAL A 113
VAL A 150
THR A 238
THR A  96
 None
 1.24A 5bykA-5xn8A:
undetectable		 5bykA-5xn8A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		4 / 6 ILE A 130
TYR A 131
PHE A 137
THR A 120
 None
 1.14A 5g08A-5xn8A:
undetectable		 5g08A-5xn8A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 TYR A 143
ILE A  77
LEU A  80
GLY A  84
LEU A 141
 None
 1.16A 5ienA-5xn8A:
undetectable		 5ienA-5xn8A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 MET A 339
ALA A 255
HIS A 254
ALA A 253
THR A 279
 None
None
ZN  A 401 (-3.4A)
None
None
 1.08A 5k9dA-5xn8A:
3.0		 5k9dA-5xn8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
None
None
 1.17A 5m66A-5xn8A:
2.2		 5m66A-5xn8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
None
None
 1.21A 5m66C-5xn8A:
3.2		 5m66C-5xn8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 ILE A 117
GLY A  93
VAL A  91
VAL A 113
ALA A 160
 None
 1.21A 5n0rA-5xn8A:
2.2		 5n0rA-5xn8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
None
None
 1.19A 5utuF-5xn8A:
undetectable		 5utuF-5xn8A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 SER A 288
ILE A 293
ALA A 355
ILE A 256
ALA A 252
 None
 1.13A 5vc0A-5xn8A:
undetectable		 5vc0A-5xn8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 SER A 288
ILE A 293
ALA A 355
ILE A 256
ALA A 252
 None
 1.05A 5vceA-5xn8A:
undetectable		 5vceA-5xn8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		5 / 12 HIS A 254
ASP A 171
THR A 120
LEU A 250
GLY A 249
 ZN  A 401 (-3.4A)
ZN  A 401 (-2.3A)
None
None
None
 1.24A 6f3nB-5xn8A:
3.7		 6f3nB-5xn8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		4 / 6 GLY A 359
LEU A 358
VAL A 314
PHE A 260
 None
 1.01A 6h7lA-5xn8A:
undetectable		 6h7lA-5xn8A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5xn8 GLYCEROL
DEHYDROGENASE
(unidentified) 		4 / 6 GLY A 359
LEU A 358
VAL A 314
PHE A 260
 None
 1.02A 6h7lB-5xn8A:
undetectable		 6h7lB-5xn8A:
14.37