SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xnc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xnc -
(-) 		5 / 11 TYR A 290
PHE A 287
SER A 260
VAL A 237
PHE A 253
 N4P  A 402 (-4.7A)
None
None
None
None
 1.46A 1q23G-5xncA:
undetectable		 1q23G-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 5xnc -
(-) 		5 / 12 GLY A 157
ILE A 180
ASP A 181
LEU A 184
ASP A 206
 MTA  A 401 ( 3.7A)
MTA  A 401 (-3.6A)
None
MTA  A 401 (-4.6A)
MTA  A 401 (-3.6A)
 0.44A 1qaoA-5xncA:
11.6		 1qaoA-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5xnc -
(-) 		5 / 11 ARG A 118
ARG A 138
GLY A 157
VAL A 155
ASP A 179
 None
None
MTA  A 401 ( 3.7A)
None
MTA  A 401 (-2.8A)
 1.45A 2ac7A-5xncA:
undetectable
2ac7B-5xncA:
undetectable		 2ac7A-5xncA:
undetectable
2ac7B-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5xnc -
(-) 		5 / 11 ILE A 180
ALA A 122
ASP A 206
PRO A 227
PHE A 236
 MTA  A 401 (-3.6A)
None
MTA  A 401 (-3.6A)
MTA  A 401 (-3.7A)
MTA  A 401 (-4.8A)
 1.31A 2admA-5xncA:
11.6		 2admA-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5xnc -
(-) 		5 / 11 ILE A 180
ALA A 122
ASP A 206
PRO A 227
PHE A 236
 MTA  A 401 (-3.6A)
None
MTA  A 401 (-3.6A)
MTA  A 401 (-3.7A)
MTA  A 401 (-4.8A)
 1.30A 2admB-5xncA:
11.6		 2admB-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_A_TPFA2472_1
(CYTOCHROME P450 121)		 5xnc -
(-) 		5 / 11 THR A 131
VAL A 130
PHE A 111
THR A 162
ALA A 165
 None
 1.49A 2ij7A-5xncA:
undetectable		 2ij7A-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5xnc -
(-) 		4 / 6 LYS A 209
GLN A 124
ILE A 180
PHE A 205
 None
None
MTA  A 401 (-3.6A)
None
 1.17A 2jn3A-5xncA:
undetectable		 2jn3A-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 5xnc -
(-) 		4 / 8 ILE A 323
LEU A 272
PHE A 276
GLY A 238
 None
 0.74A 2vdbA-5xncA:
undetectable		 2vdbA-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 5xnc -
(-) 		4 / 7 GLY A 277
ILE A 323
THR A 281
LEU A 326
 None
 0.84A 2xrhA-5xncA:
undetectable		 2xrhA-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 5xnc -
(-) 		5 / 11 ALA A 165
LEU A 166
PHE A 104
PRO A 172
GLY A 170
 None
 1.48A 3bpxA-5xncA:
6.9
3bpxB-5xncA:
6.6		 3bpxA-5xncA:
undetectable
3bpxB-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5xnc -
(-) 		5 / 11 GLY A 157
ILE A 180
ASP A 181
LEU A 184
ASP A 206
 MTA  A 401 ( 3.7A)
MTA  A 401 (-3.6A)
None
MTA  A 401 (-4.6A)
MTA  A 401 (-3.6A)
 0.47A 3grvA-5xncA:
12.5		 3grvA-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 5xnc -
(-) 		5 / 12 GLY A 157
ILE A 180
ASP A 181
LEU A 184
ASP A 206
 MTA  A 401 ( 3.7A)
MTA  A 401 (-3.6A)
None
MTA  A 401 (-4.6A)
MTA  A 401 (-3.6A)
 0.49A 3gryA-5xncA:
12.5		 3gryA-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 5xnc -
(-) 		4 / 6 SER A 318
ASP A 160
TYR A 290
PRO A 227
 N4P  A 402 ( 4.0A)
N4P  A 402 (-2.7A)
N4P  A 402 (-4.7A)
MTA  A 401 (-3.7A)
 1.43A 3jqaC-5xncA:
5.0		 3jqaC-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 5xnc -
(-) 		5 / 11 ILE A 280
ILE A 233
ILE A 241
VAL A 237
GLY A 238
 None
 0.94A 3kw4A-5xncA:
undetectable		 3kw4A-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5xnc -
(-) 		3 / 3 SER A 349
SER A 348
HIS A 123
 None
 0.83A 3mzeA-5xncA:
undetectable		 3mzeA-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5xnc -
(-) 		3 / 3 TYR A 295
ASP A 126
ASP A 344
 None
N4P  A 402 ( 3.6A)
None
 0.88A 4a6eA-5xncA:
8.8		 4a6eA-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 5xnc -
(-) 		4 / 8 THR A 134
LEU A 141
ASN A 288
PHE A 287
 None
 1.07A 4m5mA-5xncA:
undetectable		 4m5mA-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 5xnc -
(-) 		4 / 5 GLY A 238
ALA A 242
PHE A 332
GLU A 333
 None
 1.06A 4m93B-5xncA:
undetectable
4m93C-5xncA:
undetectable		 4m93B-5xncA:
undetectable
4m93C-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5xnc -
(-) 		5 / 12 ASP A 206
ARG A 208
PRO A 227
LEU A 342
PHE A 236
 MTA  A 401 (-3.6A)
MTA  A 401 ( 4.3A)
MTA  A 401 (-3.7A)
None
MTA  A 401 (-4.8A)
 1.32A 5k7uA-5xncA:
undetectable		 5k7uA-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5xnc -
(-) 		5 / 10 ILE A  28
ILE A  37
ASN A  66
TRP A  35
ILE A 307
 None
 1.31A 5lg3F-5xncA:
undetectable		 5lg3F-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5xnc -
(-) 		3 / 3 ASP A 158
PHE A 111
ARG A 118
 None
 1.12A 5yw0A-5xncA:
undetectable		 5yw0A-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 5xnc -
(-) 		3 / 3 ARG A 300
LYS A 264
ARG A 303
 None
 1.34A 6az3C-5xncA:
undetectable
6az3L-5xncA:
undetectable
6az3M-5xncA:
undetectable		 6az3C-5xncA:
undetectable
6az3L-5xncA:
undetectable
6az3M-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 5xnc -
(-) 		5 / 12 GLY A 157
ASP A 179
ILE A 180
ASP A 181
ASP A 206
 MTA  A 401 ( 3.7A)
MTA  A 401 (-2.8A)
MTA  A 401 (-3.6A)
None
MTA  A 401 (-3.6A)
 0.77A 6bq4A-5xncA:
9.0		 6bq4A-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 5xnc -
(-) 		5 / 12 GLN A 127
ASP A 179
ILE A 180
ASP A 181
ASP A 206
 MTA  A 401 ( 3.8A)
MTA  A 401 (-2.8A)
MTA  A 401 (-3.6A)
None
MTA  A 401 (-3.6A)
 1.03A 6bq4B-5xncA:
9.3		 6bq4B-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 5xnc -
(-) 		5 / 12 GLY A 157
ASP A 179
ILE A 180
ASP A 181
ASP A 206
 MTA  A 401 ( 3.7A)
MTA  A 401 (-2.8A)
MTA  A 401 (-3.6A)
None
MTA  A 401 (-3.6A)
 0.75A 6bq4B-5xncA:
9.3		 6bq4B-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5xnc -
(-) 		3 / 3 PHE A 187
ARG A 118
ALA A 165
 None
 0.88A 6ecfB-5xncA:
undetectable		 6ecfB-5xncA:
undetectable