SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xni'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A  76
ASN A  77
LEU A  79
VAL A  42
LEU A 105
 None
 1.16A 1gs4A-5xniA:
undetectable		 1gs4A-5xniA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5xni MCYF
(Microcystis
aeruginosa) 		4 / 8 GLU A  62
THR A  89
TYR A  92
ILE A  66
 None
DGL  A 301 (-4.0A)
None
None
 1.13A 1qvtA-5xniA:
undetectable		 1qvtA-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 182
LEU A 126
SER A 195
ILE A 175
LEU A 166
 None
None
DGL  A 301 (-2.8A)
None
None
 1.13A 1qzfA-5xniA:
undetectable		 1qzfA-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 182
LEU A 126
SER A 195
ILE A 175
LEU A 166
 None
None
DGL  A 301 (-2.8A)
None
None
 1.13A 1qzfB-5xniA:
undetectable		 1qzfB-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 182
LEU A 126
SER A 195
ILE A 175
LEU A 166
 None
None
DGL  A 301 (-2.8A)
None
None
 1.13A 1qzfC-5xniA:
undetectable		 1qzfC-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 182
LEU A 126
SER A 195
ILE A 175
LEU A 166
 None
None
DGL  A 301 (-2.8A)
None
None
 1.13A 1qzfD-5xniA:
undetectable		 1qzfD-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 182
LEU A 126
SER A 195
ILE A 175
LEU A 166
 None
None
DGL  A 301 (-2.8A)
None
None
 1.13A 1qzfE-5xniA:
undetectable		 1qzfE-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 PHE A 137
ILE A  83
LEU A   8
GLY A  86
ILE A  85
 None
 1.19A 2e7fA-5xniA:
undetectable		 2e7fA-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 PHE A 137
ILE A  83
LEU A   8
GLY A  86
ILE A  85
 None
 1.18A 2e7fB-5xniA:
undetectable		 2e7fB-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 PHE A 137
ILE A  83
LEU A   8
GLY A  86
ILE A  85
 None
 1.21A 2ogyA-5xniA:
undetectable		 2ogyA-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 PHE A 137
ILE A  83
LEU A   8
GLY A  86
ILE A  85
 None
 1.19A 2ogyB-5xniA:
undetectable		 2ogyB-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 182
LEU A 126
SER A 195
ILE A 175
LEU A 166
 None
None
DGL  A 301 (-2.8A)
None
None
 1.15A 2oipA-5xniA:
undetectable		 2oipA-5xniA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 182
LEU A 126
SER A 195
ILE A 175
LEU A 166
 None
None
DGL  A 301 (-2.8A)
None
None
 1.17A 2oipD-5xniA:
undetectable		 2oipD-5xniA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 182
LEU A 126
SER A 195
ILE A 175
LEU A 166
 None
None
DGL  A 301 (-2.8A)
None
None
 1.15A 3hj3B-5xniA:
undetectable		 3hj3B-5xniA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 182
LEU A 126
SER A 195
ILE A 175
LEU A 166
 None
None
DGL  A 301 (-2.8A)
None
None
 1.12A 3hj3D-5xniA:
undetectable		 3hj3D-5xniA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 ASP A 217
ILE A 111
ILE A 162
ILE A 158
PHE A 137
 None
 1.17A 3phaB-5xniA:
undetectable		 3phaB-5xniA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 182
LEU A 126
SER A 195
ILE A 175
LEU A 166
 None
None
DGL  A 301 (-2.8A)
None
None
 1.11A 4ky8A-5xniA:
undetectable		 4ky8A-5xniA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 182
LEU A 126
SER A 195
ILE A 175
LEU A 166
 None
None
DGL  A 301 (-2.8A)
None
None
 1.13A 4ky8B-5xniA:
undetectable		 4ky8B-5xniA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 182
LEU A 126
SER A 195
ILE A 175
LEU A 166
 None
None
DGL  A 301 (-2.8A)
None
None
 1.14A 4ky8D-5xniA:
undetectable		 4ky8D-5xniA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 182
LEU A 126
SER A 195
ILE A 175
LEU A 166
 None
None
DGL  A 301 (-2.8A)
None
None
 1.10A 4ky8E-5xniA:
undetectable		 4ky8E-5xniA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 182
LEU A 126
SER A 195
ILE A 175
LEU A 166
 None
None
DGL  A 301 (-2.8A)
None
None
 1.16A 4q0dA-5xniA:
undetectable		 4q0dA-5xniA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 182
LEU A 126
SER A 195
ILE A 175
LEU A 166
 None
None
DGL  A 301 (-2.8A)
None
None
 1.15A 4q0dB-5xniA:
undetectable		 4q0dB-5xniA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 182
LEU A 126
SER A 195
ILE A 175
LEU A 166
 None
None
DGL  A 301 (-2.8A)
None
None
 1.16A 4q0dE-5xniA:
undetectable		 4q0dE-5xniA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xni MCYF
(Microcystis
aeruginosa) 		4 / 6 VAL A  18
VAL A  10
ILE A 230
PHE A 226
 None
 0.95A 5jw1B-5xniA:
undetectable		 5jw1B-5xniA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5xni MCYF
(Microcystis
aeruginosa) 		4 / 8 THR A 196
SER A 107
MET A  14
ALA A  90
 DGL  A 301 (-3.2A)
None
None
None
 1.05A 5l5fY-5xniA:
undetectable
5l5fZ-5xniA:
undetectable		 5l5fY-5xniA:
14.76
5l5fZ-5xniA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 7 PHE A 137
HIS A  91
ILE A  85
SER A 128
THR A 131
 None
None
None
DGL  A 301 ( 4.0A)
None
 1.15A 5vkqA-5xniA:
undetectable
5vkqD-5xniA:
undetectable		 5vkqA-5xniA:
undetectable
5vkqD-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5xni MCYF
(Microcystis
aeruginosa) 		4 / 7 SER A 128
THR A 131
HIS A  91
ILE A  85
 DGL  A 301 ( 4.0A)
None
None
None
 1.15A 5vkqA-5xniA:
undetectable
5vkqB-5xniA:
undetectable		 5vkqA-5xniA:
undetectable
5vkqB-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5xni MCYF
(Microcystis
aeruginosa) 		4 / 7 SER A 128
THR A 131
PHE A 137
HIS A  91
 DGL  A 301 ( 4.0A)
None
None
None
 0.98A 5vkqA-5xniA:
undetectable
5vkqB-5xniA:
undetectable		 5vkqA-5xniA:
undetectable
5vkqB-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5xni MCYF
(Microcystis
aeruginosa) 		4 / 8 SER A 128
THR A 131
HIS A  91
ILE A  85
 DGL  A 301 ( 4.0A)
None
None
None
 1.13A 5vkqB-5xniA:
undetectable
5vkqC-5xniA:
undetectable		 5vkqB-5xniA:
undetectable
5vkqC-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5xni MCYF
(Microcystis
aeruginosa) 		4 / 8 SER A 128
THR A 131
PHE A 137
HIS A  91
 DGL  A 301 ( 4.0A)
None
None
None
 0.97A 5vkqB-5xniA:
undetectable
5vkqC-5xniA:
undetectable		 5vkqB-5xniA:
undetectable
5vkqC-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5xni MCYF
(Microcystis
aeruginosa) 		4 / 7 SER A 128
THR A 131
HIS A  91
ILE A  85
 DGL  A 301 ( 4.0A)
None
None
None
 1.13A 5vkqC-5xniA:
undetectable
5vkqD-5xniA:
undetectable		 5vkqC-5xniA:
undetectable
5vkqD-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5xni MCYF
(Microcystis
aeruginosa) 		4 / 7 SER A 128
THR A 131
PHE A 137
HIS A  91
 DGL  A 301 ( 4.0A)
None
None
None
 0.97A 5vkqC-5xniA:
undetectable
5vkqD-5xniA:
undetectable		 5vkqC-5xniA:
undetectable
5vkqD-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 116
ILE A 216
ILE A 111
ILE A 147
ILE A 192
 None
 0.98A 6emuB-5xniA:
2.5		 6emuB-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5xni MCYF
(Microcystis
aeruginosa) 		5 / 12 LEU A 116
ILE A 216
ILE A 111
ILE A 147
ILE A 192
 None
 0.99A 6emuC-5xniA:
2.4		 6emuC-5xniA:
undetectable