SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xnl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5xnl CYTOCHROME B559
SUBUNIT ALPHA
(Pisum
sativum) 		4 / 6 ASP E  45
LEU E  42
GLY E  41
ARG E  51
 None
 0.79A 1mt1G-5xnlE:
undetectable
1mt1J-5xnlE:
undetectable		 1mt1G-5xnlE:
22.22
1mt1J-5xnlE:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5xnl CYTOCHROME B559
SUBUNIT ALPHA
(Pisum
sativum) 		4 / 6 ARG E  51
ASP E  45
LEU E  42
GLY E  41
 None
 0.74A 1n13H-5xnlE:
undetectable
1n13K-5xnlE:
undetectable		 1n13H-5xnlE:
19.81
1n13K-5xnlE:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5xnl CYTOCHROME B559
SUBUNIT ALPHA
(Pisum
sativum) 		4 / 7 ASP E  45
LEU E  42
GLY E  41
ARG E  51
 None
 0.74A 1n13G-5xnlE:
undetectable
1n13J-5xnlE:
undetectable		 1n13G-5xnlE:
22.22
1n13J-5xnlE:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 3
(Pisum
sativum) 		3 / 3 ASP Q  87
TYR Q  83
GLU Q  53
 None
 0.86A 1vm1A-5xnlQ:
undetectable		 1vm1A-5xnlQ:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC
(Pisum
sativum) 		5 / 12 GLY O  44
GLY O  91
ASN O  47
ALA O  48
ALA O 244
 None
 0.88A 2bm9F-5xnlO:
undetectable		 2bm9F-5xnlO:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC
OXYGEN-EVOLVING
ENHANCER PROTEIN 2,
CHLOROPLASTIC
(Pisum
sativum) 		4 / 7 SER O 165
ASP P 137
SER O 155
SER O 154
 None
 0.93A 2cmlA-5xnlO:
undetectable		 2cmlA-5xnlO:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC
OXYGEN-EVOLVING
ENHANCER PROTEIN 2,
CHLOROPLASTIC
(Pisum
sativum) 		4 / 8 SER O 165
ASP P 137
SER O 155
SER O 154
 None
 0.88A 2cmlC-5xnlO:
undetectable		 2cmlC-5xnlO:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC
OXYGEN-EVOLVING
ENHANCER PROTEIN 2,
CHLOROPLASTIC
(Pisum
sativum) 		4 / 8 SER O 165
ASP P 137
SER O 155
SER O 154
 None
 0.91A 2cmlD-5xnlO:
undetectable		 2cmlD-5xnlO:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5xnl CYTOCHROME B559
SUBUNIT ALPHA
(Pisum
sativum) 		4 / 7 ARG E  51
ASP E  45
LEU E  42
GLY E  41
 None
 0.79A 2qqcD-5xnlE:
undetectable
2qqcE-5xnlE:
undetectable		 2qqcD-5xnlE:
20.00
2qqcE-5xnlE:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5xnl CYTOCHROME B559
SUBUNIT ALPHA
(Pisum
sativum) 		4 / 8 ARG E  51
ASP E  45
LEU E  42
GLY E  41
 None
 0.69A 2qqdB-5xnlE:
undetectable
2qqdC-5xnlE:
undetectable		 2qqdB-5xnlE:
20.00
2qqdC-5xnlE:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5xnl LIGHT HARVESTING
CHLOROPHYLL
A/B-BINDING PROTEIN
LHCB5, CP26
(Pisum
sativum) 		4 / 5 ARG S 194
PRO S  54
GLY S  55
TRP S  26
 CLA  S 602 (-4.2A)
None
CLA  S 602 (-4.7A)
CLA  S 611 ( 4.1A)
 0.80A 2y7kB-5xnlS:
undetectable		 2y7kB-5xnlS:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5xnl LIGHT HARVESTING
CHLOROPHYLL
A/B-BINDING PROTEIN
LHCB5, CP26
(Pisum
sativum) 		4 / 6 ARG S 194
PRO S  54
GLY S  55
TRP S  26
 CLA  S 602 (-4.2A)
None
CLA  S 602 (-4.7A)
CLA  S 611 ( 4.1A)
 0.84A 2y7pA-5xnlS:
undetectable		 2y7pA-5xnlS:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC
(Pisum
sativum) 		5 / 12 ASN O  27
PHE O 218
ALA O 112
GLU O  54
VAL O 116
 None
 1.12A 3c6gB-5xnlO:
undetectable		 3c6gB-5xnlO:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC
(Pisum
sativum) 		3 / 3 ASN O 170
ASN O 190
GLU O 183
 None
 0.78A 3kpdC-5xnlO:
undetectable		 3kpdC-5xnlO:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 2,
CHLOROPLASTIC
(Pisum
sativum) 		3 / 3 TYR P 127
THR P  72
GLU P  78
 None
 0.83A 4df3A-5xnlP:
undetectable		 4df3A-5xnlP:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 2,
CHLOROPLASTIC
(Pisum
sativum) 		3 / 3 TYR P 127
THR P  72
GLU P  78
 None
 0.84A 4df3B-5xnlP:
undetectable		 4df3B-5xnlP:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC
(Pisum
sativum) 		5 / 11 LEU O  53
LEU O  86
ILE O  89
LEU O 133
ILE O 238
 None
 1.16A 4dm8A-5xnlO:
undetectable		 4dm8A-5xnlO:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 2,
CHLOROPLASTIC
(Pisum
sativum) 		4 / 5 VAL P 131
LEU P  81
ILE P 129
LEU P 146
 None
 0.87A 4mghA-5xnlP:
undetectable		 4mghA-5xnlP:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 5xnl LIGHT HARVESTING
CHLOROPHYLL
A/B-BINDING PROTEIN
LHCB5, CP26
(Pisum
sativum) 		4 / 6 VAL S  53
ASP S  56
SER S  65
ALA S  47
 None
CLA  S 602 (-4.0A)
CLA  S 602 ( 4.0A)
None
 1.14A 4nedA-5xnlS:
undetectable		 4nedA-5xnlS:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC
(Pisum
sativum) 		4 / 8 SER O 196
GLY O 229
ALA O 194
THR O 226
 None
 0.93A 5eevL-5xnlO:
undetectable
5eevV-5xnlO:
undetectable		 5eevL-5xnlO:
16.88
5eevV-5xnlO:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC
(Pisum
sativum) 		4 / 8 SER O 196
GLY O 229
ALA O 194
THR O 226
 None
 0.93A 5eewL-5xnlO:
undetectable
5eewV-5xnlO:
undetectable		 5eewL-5xnlO:
16.88
5eewV-5xnlO:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC
(Pisum
sativum) 		4 / 8 SER O 196
GLY O 229
ALA O 194
THR O 226
 None
 0.93A 5ef3L-5xnlO:
undetectable
5ef3V-5xnlO:
undetectable		 5ef3L-5xnlO:
16.88
5ef3V-5xnlO:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5xnl LIGHT HARVESTING
CHLOROPHYLL
A/B-BINDING PROTEIN
LHCB4, CP29
(Pisum
sativum) 		4 / 8 GLY R 211
LEU R 210
ALA R 103
PHE R 209
 CLA  R 613 (-3.3A)
XAT  R 622 ( 4.0A)
XAT  R 622 ( 3.9A)
XAT  R 622 (-4.0A)
 0.92A 5xu8A-5xnlR:
undetectable		 5xu8A-5xnlR:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 2,
CHLOROPLASTIC
OXYGEN-EVOLVING
ENHANCER PROTEIN 3
(Pisum
sativum;
Pisum
sativum) 		3 / 3 ARG P 173
ARG Q  27
ASP Q  24
 None
 0.94A 6d8pA-5xnlP:
undetectable		 6d8pA-5xnlP:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5xnl CYTOCHROME B559
SUBUNIT ALPHA
(Pisum
sativum) 		3 / 3 PHE E  56
ARG E  60
GLN E  61
 None
 1.13A 6g1pB-5xnlE:
undetectable		 6g1pB-5xnlE:
13.17