SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xnm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 5xnm PHOTOSYSTEM II
REACTION CENTER
PROTEIN Z
(Pisum
sativum) 		3 / 3 VAL Z  51
VAL Z   9
TRP Z  47
 None
 0.83A 1av2C-5xnmZ:
undetectable
1av2D-5xnmZ:
undetectable		 1av2C-5xnmZ:
20.37
1av2D-5xnmZ:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN
(Pisum
sativum) 		4 / 5 GLU B 283
ARG B 358
LEU B 309
ASP B 313
 None
 1.22A 1n13B-5xnmB:
undetectable
1n13C-5xnmB:
undetectable		 1n13B-5xnmB:
13.88
1n13C-5xnmB:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 5xnm PHOTOSYSTEM II
REACTION CENTER
PROTEIN Z
(Pisum
sativum) 		3 / 3 VAL Z  51
VAL Z   9
TRP Z  47
 None
 0.76A 1w5uC-5xnmZ:
undetectable
1w5uD-5xnmZ:
undetectable		 1w5uC-5xnmZ:
20.37
1w5uD-5xnmZ:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 5xnm PHOTOSYSTEM II
REACTION CENTER
PROTEIN Z
(Pisum
sativum) 		3 / 3 VAL Z   9
TRP Z  47
VAL Z  51
 None
 0.79A 2izqA-5xnmZ:
undetectable
2izqB-5xnmZ:
undetectable		 2izqA-5xnmZ:
20.37
2izqB-5xnmZ:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN
(Pisum
sativum) 		4 / 8 TYR B 172
SER B 446
PRO B  54
THR B 452
 None
None
None
DGD  H 102 ( 4.7A)
 1.15A 2v0zO-5xnmB:
undetectable		 2v0zO-5xnmB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN
PHOTOSYSTEM II
LUMINAL EXTRINSIC
PROTEIN TN, PSBTN
(Pisum
sativum) 		4 / 4 GLY B 278
VAL U  16
GLY U   5
THR U   6
 None
 0.91A 3ib2A-5xnmB:
undetectable		 3ib2A-5xnmB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN
(Pisum
sativum) 		4 / 6 PHE B 311
ASP B 334
TYR B 314
PRO B  54
 None
 1.31A 3jqaA-5xnmB:
undetectable		 3jqaA-5xnmB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN
(Pisum
sativum) 		4 / 6 PHE B 311
ASP B 334
TYR B 314
PRO B  54
 None
 1.37A 3jqaB-5xnmB:
undetectable		 3jqaB-5xnmB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 5xnm PHOTOSYSTEM II
REACTION CENTER
PROTEIN Z
(Pisum
sativum) 		3 / 3 VAL Z  51
VAL Z   9
TRP Z  47
 None
 0.68A 3l8lC-5xnmZ:
undetectable
3l8lD-5xnmZ:
undetectable		 3l8lC-5xnmZ:
20.37
3l8lD-5xnmZ:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN
(Pisum
sativum) 		3 / 3 ARG B 357
THR B 361
TRP B 275
 None
 1.23A 4d7hA-5xnmB:
undetectable		 4d7hA-5xnmB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN
PHOTOSYSTEM II
LUMINAL EXTRINSIC
PROTEIN TN, PSBTN
(Pisum
sativum) 		4 / 7 PHE B 355
HIS B 343
ILE B 284
PRO U  15
 None
 0.97A 4g5jA-5xnmB:
undetectable		 4g5jA-5xnmB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN
(Pisum
sativum) 		3 / 3 ARG B 357
THR B 361
TRP B 275
 None
 1.12A 4ug5A-5xnmB:
undetectable		 4ug5A-5xnmB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN
(Pisum
sativum) 		3 / 3 ARG B 357
THR B 361
TRP B 275
 None
 1.23A 4uglA-5xnmB:
undetectable		 4uglA-5xnmB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN
(Pisum
sativum) 		5 / 12 GLY B 154
ILE B 265
GLY B 173
GLY B 176
THR B 159
 None
None
None
None
LMG  B2633 (-4.2A)
 1.11A 5eqbA-5xnmB:
undetectable		 5eqbA-5xnmB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN
(Pisum
sativum) 		3 / 3 ARG B 357
THR B 361
TRP B 275
 None
 1.18A 5g6cA-5xnmB:
undetectable		 5g6cA-5xnmB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN
(Pisum
sativum) 		4 / 6 SER B 289
GLU B 353
ARG B 352
ASP B 372
 None
 1.10A 5zw4A-5xnmB:
undetectable		 5zw4A-5xnmB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN
(Pisum
sativum) 		3 / 3 SER B 388
LYS B 389
SER B 391
 None
 0.83A 6az3P-5xnmB:
undetectable		 6az3P-5xnmB:
11.19