SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xnp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 6 SER A 155
ARG A 256
LEU A 248
TRP A 250
 None
 1.12A 1gahA-5xnpA:
undetectable		 1gahA-5xnpA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5xnp RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Homo
sapiens) 		4 / 7 PHE D 229
ALA D 304
ILE D 246
PRO D 233
 None
 1.14A 1oniA-5xnpD:
undetectable
1oniB-5xnpD:
undetectable		 1oniA-5xnpD:
undetectable
1oniB-5xnpD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5xnp RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Homo
sapiens) 		4 / 6 PHE D 229
ALA D 304
ILE D 246
PRO D 233
 None
 1.23A 1oniH-5xnpD:
undetectable
1oniI-5xnpD:
undetectable		 1oniH-5xnpD:
undetectable
1oniI-5xnpD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 LEU A 200
PHE A 191
LEU A 235
ILE A 162
LEU A 242
 None
 1.11A 2hrcB-5xnpA:
undetectable		 2hrcB-5xnpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Homo
sapiens) 		5 / 12 MET D 130
LEU D 146
ILE A 318
ALA A 317
LEU A 327
 None
 1.04A 2japA-5xnpD:
undetectable		 2japA-5xnpD:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Homo
sapiens) 		5 / 12 MET D 130
LEU D 146
ILE A 318
ALA A 317
LEU A 327
 None
 1.01A 2japB-5xnpD:
undetectable		 2japB-5xnpD:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Homo
sapiens) 		5 / 12 MET D 130
LEU D 146
ILE A 318
ALA A 317
LEU A 327
 None
 1.08A 2japC-5xnpD:
undetectable		 2japC-5xnpD:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Homo
sapiens) 		5 / 12 MET D 130
LEU D 146
ILE A 318
ALA A 317
LEU A 327
 None
 1.07A 2japD-5xnpD:
undetectable		 2japD-5xnpD:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 5xnp RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Homo
sapiens) 		5 / 12 ARG D  83
LEU D 113
PHE D  43
ALA D  41
VAL D  40
 None
 0.98A 2oc8A-5xnpD:
undetectable		 2oc8A-5xnpD:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 MET A  74
LEU A  80
LEU A  56
ILE A  90
VAL A  63
 None
 1.12A 2po7A-5xnpA:
undetectable		 2po7A-5xnpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 LEU A 200
PHE A 191
LEU A 235
ILE A 162
LEU A 242
 None
 1.21A 2po7B-5xnpA:
undetectable		 2po7B-5xnpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 LEU A 106
ASN A 107
LEU A 130
LEU A  80
THR A  81
 None
SO4  A 414 (-3.5A)
None
None
SO4  A 414 ( 3.9A)
 1.26A 2q7kA-5xnpA:
undetectable		 2q7kA-5xnpA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 PHE A 191
LEU A 128
LEU A 152
ILE A 114
ALA A 142
 None
 1.26A 2v0mC-5xnpA:
undetectable		 2v0mC-5xnpA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 LEU A  77
LEU A  58
LEU A 104
ARG A  57
 None
 0.86A 2xn3A-5xnpA:
undetectable
2xn3B-5xnpA:
undetectable		 2xn3A-5xnpA:
13.74
2xn3B-5xnpA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 SER A  88
THR A 112
ILE A 114
ASN A  65
ILE A  66
 None
None
None
CL  A 411 ( 4.5A)
None
 1.21A 3ddyA-5xnpA:
undetectable		 3ddyA-5xnpA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5xnp RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Homo
sapiens) 		5 / 12 SER D  42
ALA D  41
GLY D  35
VAL D  36
GLY D  39
 None
 1.12A 3f8wA-5xnpD:
undetectable		 3f8wA-5xnpD:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5xnp RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Homo
sapiens) 		5 / 12 SER D  42
ALA D  41
GLY D  35
VAL D  36
GLY D  39
 None
 1.13A 3f8wC-5xnpD:
undetectable		 3f8wC-5xnpD:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 9 LEU A 248
PHE A 282
ILE A 277
ALA A 264
THR A 262
 None
 1.28A 3mdtA-5xnpA:
undetectable		 3mdtA-5xnpA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 7 ASN A  85
ILE A  66
PHE A  95
MET A 118
 None
 1.27A 3tvxB-5xnpA:
undetectable		 3tvxB-5xnpA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 MET A  74
LEU A  80
LEU A  56
ILE A  90
VAL A  63
 None
 1.13A 3w1wA-5xnpA:
undetectable		 3w1wA-5xnpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 MET A  74
LEU A  80
LEU A  56
ILE A  90
VAL A  63
 None
 1.18A 3w1wB-5xnpA:
undetectable		 3w1wB-5xnpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 LEU A 207
VAL A 202
ALA A 219
PHE A 191
THR A 190
 None
 1.11A 4iarA-5xnpA:
undetectable		 4iarA-5xnpA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 LEU A 130
LEU A 154
LEU A 176
ILE A 114
VAL A 146
 None
 1.29A 4mk4A-5xnpA:
undetectable		 4mk4A-5xnpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 LEU A 111
ASN A 133
LEU A 104
HIS A 105
 None
None
None
SO4  A 414 ( 3.8A)
 1.04A 4ok1A-5xnpA:
undetectable		 4ok1A-5xnpA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Homo
sapiens) 		5 / 12 ALA D 182
ALA A 359
ILE A 358
MET D 130
GLY D 131
 None
 1.14A 4r38A-5xnpD:
undetectable		 4r38A-5xnpD:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Homo
sapiens) 		5 / 12 ALA D 182
ALA A 359
ILE A 358
MET D 130
GLY D 131
 None
 1.13A 4r38C-5xnpD:
undetectable		 4r38C-5xnpD:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Homo
sapiens) 		5 / 12 ALA D 182
ALA A 359
ILE A 358
MET D 130
GLY D 131
 None
 1.14A 4r38D-5xnpD:
undetectable		 4r38D-5xnpD:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 6 GLU A 279
LEU A 254
ARG A 252
ARG A 253
 None
 1.13A 5l6eA-5xnpA:
undetectable
5l6eB-5xnpA:
undetectable		 5l6eA-5xnpA:
undetectable
5l6eB-5xnpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		3 / 3 ASP A 258
PHE A 237
ARG A 256
 None
 1.10A 5yw0A-5xnpA:
undetectable		 5yw0A-5xnpA:
undetectable