SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xnr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		4 / 6 ASP A 447
ASN A 463
ASP A 446
TYR A 541
 None
 1.24A 1hpkA-5xnrA:
undetectable		 1hpkA-5xnrA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		4 / 7 GLY A 251
SER A 268
PHE A 296
GLU A 265
 None
 0.96A 2c8aB-5xnrA:
undetectable		 2c8aB-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		4 / 7 GLY A 251
SER A 268
PHE A 296
GLU A 265
 None
 0.99A 2c8aD-5xnrA:
undetectable		 2c8aD-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		4 / 7 GLY A 297
THR A 302
TRP A 303
SER A 217
 None
None
ACT  A 603 (-4.0A)
ACT  A 603 ( 4.5A)
 1.19A 2o5yH-5xnrA:
undetectable
2o5yL-5xnrA:
2.1		 2o5yH-5xnrA:
19.89
2o5yL-5xnrA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		3 / 3 GLU A 549
GLN A 543
ARG A 452
 None
None
PO4  A 604 (-3.3A)
 0.81A 2w3bB-5xnrA:
undetectable		 2w3bB-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		4 / 5 GLN A 420
ALA A 434
GLN A 436
ILE A 538
 None
 1.48A 2z0aA-5xnrA:
undetectable		 2z0aA-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		4 / 8 ILE A 343
TYR A 345
ASP A 347
SER A 349
 None
 0.61A 3pwwA-5xnrA:
undetectable		 3pwwA-5xnrA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA597_0
(LACTOPEROXIDASE)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		4 / 5 GLN A 436
ASP A 447
HIS A 438
GLU A 394
 None
 1.36A 3r4xA-5xnrA:
undetectable		 3r4xA-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA597_0
(LACTOPEROXIDASE)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		4 / 5 GLN A 436
ASP A 447
HIS A 438
GLU A 394
 None
 1.40A 3r55A-5xnrA:
undetectable		 3r55A-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		3 / 3 PRO A 346
ASP A 347
GLU A 361
 None
 0.86A 3v4tC-5xnrA:
undetectable		 3v4tC-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		3 / 3 ARG A 396
LYS A 537
ARG A 392
 None
 1.34A 3w1wA-5xnrA:
undetectable
3w1wB-5xnrA:
undetectable		 3w1wA-5xnrA:
undetectable
3w1wB-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		3 / 3 ARG A 392
ARG A 396
LYS A 537
 None
 1.30A 3w1wA-5xnrA:
undetectable
3w1wB-5xnrA:
undetectable		 3w1wA-5xnrA:
undetectable
3w1wB-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		4 / 8 GLU A 323
GLU A 322
GLY A 326
LYS A 369
 None
 1.03A 4fgzA-5xnrA:
undetectable
4fgzB-5xnrA:
undetectable		 4fgzA-5xnrA:
undetectable
4fgzB-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		3 / 3 TYR A 390
ARG A 452
HIS A 431
 PO4  A 604 (-4.7A)
PO4  A 604 (-3.3A)
None
 1.04A 4fubA-5xnrA:
undetectable		 4fubA-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		3 / 3 VAL A 450
ALA A 434
PHE A 487
 None
 0.63A 4z4iA-5xnrA:
undetectable		 4z4iA-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		4 / 4 LEU A 432
TYR A 345
PRO A 377
ILE A 378
 None
 1.38A 5esgA-5xnrA:
undetectable		 5esgA-5xnrA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		3 / 3 VAL A 450
ALA A 434
PHE A 487
 None
 0.63A 5js1A-5xnrA:
undetectable		 5js1A-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		3 / 3 PRO A 386
SER A 388
SER A 389
 None
 0.63A 6bpyA-5xnrA:
undetectable		 6bpyA-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		5 / 12 VAL A 569
VAL A 416
GLY A 439
THR A 411
GLY A 412
 None
 1.13A 6brdC-5xnrA:
undetectable		 6brdC-5xnrA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 5xnr ALYQ
(Persicobacter
sp.
CCB-QB2) 		3 / 3 ARG A 396
ARG A 398
ASP A 405
 None
 0.95A 6d8pA-5xnrA:
undetectable		 6d8pA-5xnrA:
undetectable