SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A
(Pyrococcus
furiosus) 		4 / 8 PHE C 184
ILE C 207
LEU C 188
VAL A1153
 None
 0.86A 1fslB-5xnsC:
undetectable		 1fslB-5xnsC:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 12 PHE A  28
GLY A  27
ILE A1140
SER A1156
LEU A1157
 None
 0.91A 1v2xA-5xnsA:
undetectable		 1v2xA-5xnsA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 12 PHE A1093
LYS A  26
ILE A  84
PHE A  86
GLY A  43
 None
 1.18A 2lbdA-5xnsA:
undetectable		 2lbdA-5xnsA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 12 ILE A  31
ILE A 135
ILE A 142
LEU A 144
LEU A   7
 None
 1.13A 2qo5A-5xnsA:
undetectable		 2qo5A-5xnsA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 11 ILE A1099
PHE A1124
PHE A1096
VAL A 143
THR A1128
 None
None
None
None
CIT  A1202 (-3.9A)
 1.09A 2w3aA-5xnsA:
undetectable		 2w3aA-5xnsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		6 / 12 VAL A1143
GLY A1142
LEU C 188
ILE A1127
LEU A   7
ILE A  46
 None
 1.40A 3ijdA-5xnsA:
undetectable		 3ijdA-5xnsA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		6 / 12 VAL A1143
GLY A1142
LEU C 188
ILE A1127
LEU A   7
ILE A  46
 None
 1.40A 3ijdB-5xnsA:
undetectable		 3ijdB-5xnsA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		3 / 3 GLU A1117
LEU A1114
ASP A1113
 None
 0.41A 3ko0A-5xnsA:
undetectable		 3ko0A-5xnsA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		3 / 3 GLU A1117
LEU A1114
ASP A1113
 None
 0.39A 3ko0T-5xnsA:
undetectable		 3ko0T-5xnsA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 12 PHE A  28
GLY A  27
ILE A1140
SER A1156
LEU A1157
 None
 0.91A 3nk7B-5xnsA:
undetectable		 3nk7B-5xnsA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 11 GLN A1123
PHE A  86
ASN A  87
ALA A  83
GLU A  81
 None
 1.11A 4a6nA-5xnsA:
undetectable		 4a6nA-5xnsA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		4 / 7 PHE A  12
TYR A  15
VAL A  82
ILE A  84
 None
 0.99A 4a97E-5xnsA:
5.5		 4a97E-5xnsA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		4 / 8 PHE A  12
TYR A  15
VAL A  82
ILE A  84
 None
 0.98A 4a97C-5xnsA:
undetectable		 4a97C-5xnsA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		4 / 8 PHE A  12
TYR A  15
VAL A  82
ILE A  84
 None
 1.01A 4a97G-5xnsA:
undetectable		 4a97G-5xnsA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A
(Pyrococcus
furiosus) 		4 / 8 SER A1144
GLY A1148
MET C 193
GLY C 194
 None
 0.87A 4fo4B-5xnsA:
undetectable		 4fo4B-5xnsA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		3 / 3 ARG A 980
LEU A 984
GLU A 983
 None
 0.72A 4l3gF-5xnsA:
undetectable		 4l3gF-5xnsA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		4 / 7 ASN A 189
GLU A 994
GLU A 992
GLU A 187
 None
 0.99A 4mi4B-5xnsA:
undetectable
4mi4C-5xnsA:
undetectable		 4mi4B-5xnsA:
20.65
4mi4C-5xnsA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		4 / 7 ASN A 189
GLU A 994
GLU A 992
GLU A 187
 None
 0.99A 4mi4A-5xnsA:
undetectable
4mi4C-5xnsA:
undetectable		 4mi4A-5xnsA:
20.65
4mi4C-5xnsA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		4 / 8 ASN A 189
GLU A 994
GLU A 992
GLU A 187
 None
 0.97A 4mj8A-5xnsA:
undetectable
4mj8C-5xnsA:
undetectable		 4mj8A-5xnsA:
20.94
4mj8C-5xnsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		4 / 8 ASN A 189
GLU A 994
GLU A 992
GLU A 187
 None
 0.98A 4mj8B-5xnsA:
undetectable
4mj8C-5xnsA:
undetectable		 4mj8B-5xnsA:
20.94
4mj8C-5xnsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		3 / 3 MET A 154
GLU A 158
LEU A 162
 None
 0.63A 4v2oB-5xnsA:
4.8		 4v2oB-5xnsA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 11 LEU A1031
GLY A1072
LEU A1114
THR A1077
ALA A1080
 None
 1.02A 5o96A-5xnsA:
undetectable
5o96B-5xnsA:
undetectable		 5o96A-5xnsA:
18.47
5o96B-5xnsA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 10 MET A1133
ALA A1101
LEU A1103
ILE A1054
LEU A1039
 None
CIT  A1201 (-4.2A)
None
None
None
 1.08A 5oy01-5xnsA:
4.1
5oy07-5xnsA:
undetectable		 5oy01-5xnsA:
10.23
5oy07-5xnsA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5xns CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
furiosus) 		5 / 12 ILE A  46
LEU A1114
PHE A1096
LEU A1079
TYR A 140
 None
 1.41A 6a93A-5xnsA:
6.1		 6a93A-5xnsA:
24.50