SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xnu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 8 TYR A 397
GLU A 244
HIS A 512
SER A 286
 None
ZN  A 601 (-1.8A)
None
None
 1.31A 1nx9A-5xnuA:
undetectable		 1nx9A-5xnuA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 8 ASN A 415
GLU A 413
GLY A 414
PHE A 398
 None
 1.06A 1ykiA-5xnuA:
undetectable
1ykiB-5xnuA:
undetectable		 1ykiA-5xnuA:
18.69
1ykiB-5xnuA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 8 PHE A 398
ASN A 415
GLU A 413
GLY A 414
 None
 1.08A 1ykiA-5xnuA:
undetectable
1ykiB-5xnuA:
undetectable		 1ykiA-5xnuA:
18.69
1ykiB-5xnuA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 8 ASN A 415
GLU A 413
GLY A 414
PHE A 398
 None
 1.03A 1ykiC-5xnuA:
undetectable
1ykiD-5xnuA:
undetectable		 1ykiC-5xnuA:
18.69
1ykiD-5xnuA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 7 SER A 274
ASP A 507
SER A 506
ASN A 254
 None
 1.03A 2cmlA-5xnuA:
undetectable		 2cmlA-5xnuA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 8 SER A 274
ASP A 507
SER A 506
ASN A 254
 None
 1.01A 2cmlB-5xnuA:
undetectable		 2cmlB-5xnuA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		5 / 8 SER A 274
ASP A 507
SER A 506
ASN A 254
GLN A 252
 None
 1.34A 2cmlC-5xnuA:
undetectable		 2cmlC-5xnuA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 8 SER A 274
ASP A 507
SER A 506
ASN A 254
 None
 1.10A 2cmlD-5xnuA:
undetectable		 2cmlD-5xnuA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 6 HIS A 220
ASP A 302
THR A 303
TYR A 306
 None
 1.47A 2dysA-5xnuA:
undetectable
2dysC-5xnuA:
undetectable		 2dysA-5xnuA:
undetectable
2dysC-5xnuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 6 HIS A 220
ASP A 302
THR A 303
TYR A 306
 None
 1.47A 2dysN-5xnuA:
undetectable
2dysP-5xnuA:
undetectable		 2dysN-5xnuA:
undetectable
2dysP-5xnuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 7 HIS A 220
ASP A 302
THR A 303
TYR A 306
 None
 1.46A 2eikA-5xnuA:
undetectable
2eikC-5xnuA:
undetectable		 2eikA-5xnuA:
undetectable
2eikC-5xnuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 6 HIS A 220
ASP A 302
THR A 303
TYR A 306
 None
 1.49A 2eimA-5xnuA:
undetectable
2eimC-5xnuA:
undetectable		 2eimA-5xnuA:
undetectable
2eimC-5xnuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 6 HIS A 220
ASP A 302
THR A 303
TYR A 306
 None
 1.47A 2einA-5xnuA:
undetectable
2einC-5xnuA:
undetectable		 2einA-5xnuA:
undetectable
2einC-5xnuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 8 ASP A 329
SER A 328
HIS A 388
ASP A 325
 None
 1.06A 2xadA-5xnuA:
undetectable		 2xadA-5xnuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 8 ASP A 329
SER A 328
HIS A 388
ASP A 325
 None
 1.08A 2xadB-5xnuA:
undetectable		 2xadB-5xnuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 8 ASP A 329
SER A 328
HIS A 388
ASP A 325
 None
 1.04A 2xadC-5xnuA:
undetectable		 2xadC-5xnuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 8 ASP A 329
SER A 328
HIS A 388
ASP A 325
 None
 1.07A 2xadD-5xnuA:
undetectable		 2xadD-5xnuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 6 HIS A 220
ASP A 302
THR A 303
TYR A 306
 None
 1.45A 3ag1A-5xnuA:
undetectable
3ag1C-5xnuA:
undetectable		 3ag1A-5xnuA:
undetectable
3ag1C-5xnuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		3 / 3 TYR A 429
ASP A 249
HIS A 464
 None
None
ZN  A 601 (-3.2A)
 0.97A 3e23A-5xnuA:
2.1		 3e23A-5xnuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 314
GLY A 318
ARG A 233
PHE A 523
MET A 386
 None
 1.19A 3h52C-5xnuA:
undetectable		 3h52C-5xnuA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		3 / 3 GLY A 332
SER A 330
TRP A 323
 None
 1.00A 4e7cD-5xnuA:
undetectable		 4e7cD-5xnuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 5 GLY A 370
THR A 449
VAL A 375
ASP A 373
 None
 1.07A 4eohA-5xnuA:
undetectable		 4eohA-5xnuA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 510
LEU A 519
VAL A 310
VAL A 461
PHE A 240
 None
 1.21A 4wnwA-5xnuA:
undetectable		 4wnwA-5xnuA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		3 / 3 ASP A 329
GLY A 332
ASP A 335
 None
 0.54A 4xdtA-5xnuA:
undetectable		 4xdtA-5xnuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		6 / 6 GLY A 280
THR A 281
SER A 282
TYR A 285
GLY A 477
ASN A 480
 None
 0.37A 5k4pA-5xnuA:
56.7		 5k4pA-5xnuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 5 PHE A 494
PHE A 493
LEU A 270
LEU A 510
 None
 1.21A 5veuH-5xnuA:
undetectable		 5veuH-5xnuA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN
(Escherichia
coli) 		4 / 8 ILE A 218
THR A 217
THR A 313
ARG A 316
 None
 1.08A 6c06C-5xnuA:
undetectable		 6c06C-5xnuA:
undetectable