SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xnw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5xnw ADENYLATE CYCLASE
EXOY
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 339
PHE A 306
VAL A 333
GLY A  62
ILE A 346
 None
 1.05A 1z11A-5xnwA:
undetectable		 1z11A-5xnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5xnw ADENYLATE CYCLASE
EXOY
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 306
VAL A 333
GLY A  62
ILE A 346
LEU A 342
 None
 1.13A 1z11C-5xnwA:
undetectable		 1z11C-5xnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5xnw ADENYLATE CYCLASE
EXOY
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 207
VAL A 273
LEU A 276
ARG A  64
 None
 1.06A 2oiqA-5xnwA:
undetectable		 2oiqA-5xnwA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5xnw ADENYLATE CYCLASE
EXOY
(Pseudomonas
aeruginosa) 		4 / 5 VAL A 332
THR A 309
VAL A  42
GLY A  41
 None
 0.89A 2p2fA-5xnwA:
undetectable		 2p2fA-5xnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5xnw ADENYLATE CYCLASE
EXOY
(Pseudomonas
aeruginosa) 		4 / 4 VAL A 332
THR A 309
VAL A  42
GLY A  41
 None
 0.86A 2p2fB-5xnwA:
undetectable		 2p2fB-5xnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 5xnw ADENYLATE CYCLASE
EXOY
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 286
VAL A  70
THR A 210
 None
 0.75A 3cyxA-5xnwA:
undetectable		 3cyxA-5xnwA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5xnw ADENYLATE CYCLASE
EXOY
(Pseudomonas
aeruginosa) 		4 / 4 PHE A  83
TYR A 132
ILE A  63
LEU A 215
 None
 1.45A 3sudA-5xnwA:
undetectable		 3sudA-5xnwA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 5xnw ADENYLATE CYCLASE
EXOY
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 197
ALA A 196
GLY A  93
PHE A 176
ASP A 102
 None
 1.30A 4mm9A-5xnwA:
undetectable		 4mm9A-5xnwA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5xnw ADENYLATE CYCLASE
EXOY
(Pseudomonas
aeruginosa) 		3 / 3 SER A 194
ALA A 196
VAL A 197
 None
 0.61A 4o2bA-5xnwA:
undetectable		 4o2bA-5xnwA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xnw ADENYLATE CYCLASE
EXOY
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 137
GLY A  97
ALA A  96
SER A  90
 None
 0.72A 5f1aA-5xnwA:
undetectable		 5f1aA-5xnwA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 5xnw ADENYLATE CYCLASE
EXOY
(Pseudomonas
aeruginosa) 		3 / 3 THR A 113
HIS A 104
ASN A 120
 None
 0.95A 5n4tA-5xnwA:
undetectable		 5n4tA-5xnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5xnw ADENYLATE CYCLASE
EXOY
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 143
ARG A 149
ARG A 141
 None
 0.89A 5vcgA-5xnwA:
undetectable		 5vcgA-5xnwA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 5xnw ADENYLATE CYCLASE
EXOY
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 346
LEU A 312
PRO A 313
THR A  57
PHE A  61
 None
 1.38A 6hupA-5xnwA:
undetectable
6hupB-5xnwA:
undetectable		 6hupA-5xnwA:
24.10
6hupB-5xnwA:
19.77