SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xnx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UYU_A_CAMA1416_0 (CYTOCHROME P450-CAM)	5xnx	BIFUNCTIONAL (P)PPGPP SYNTHASE/HYDROLASE RELA (Mycobacterium tuberculosis)	4 / 8	LEU A 188 VAL A 184 VAL A 60 ASP A 145	None None None MG A 401 (-3.7A)	1.15A	1uyuA-5xnxA: undetectable	1uyuA-5xnxA: 21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UYU_B_CAMB1416_0 (CYTOCHROME P450-CAM)	5xnx	BIFUNCTIONAL (P)PPGPP SYNTHASE/HYDROLASE RELA (Mycobacterium tuberculosis)	4 / 8	LEU A 188 VAL A 184 VAL A 60 ASP A 145	None None None MG A 401 (-3.7A)	1.18A	1uyuB-5xnxA: undetectable	1uyuB-5xnxA: 21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CZV_A_AZMA263_1 (CARBONIC ANHYDRASE 13)	5xnx	BIFUNCTIONAL (P)PPGPP SYNTHASE/HYDROLASE RELA (Mycobacterium tuberculosis)	5 / 12	HIS A 287 VAL A 285 THR A 314 VAL A 326 VAL A 239	None	1.22A	3czvA-5xnxA: undetectable 3czvB-5xnxA: undetectable	3czvA-5xnxA: 22.93 3czvB-5xnxA: 22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L4E_A_CAMA503_0 (CAMPHOR 5-MONOOXYGENASE)	5xnx	BIFUNCTIONAL (P)PPGPP SYNTHASE/HYDROLASE RELA (Mycobacterium tuberculosis)	4 / 8	LEU A 188 VAL A 184 VAL A 60 ASP A 145	None None None MG A 401 (-3.7A)	1.16A	4l4eA-5xnxA: undetectable	4l4eA-5xnxA: 22.20

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1UYU_A_CAMA1416_0","CYTOCHROME P450-CAM","5xnx","BIFUNCTIONAL (P)PPGPP SYNTHASE\/HYDROLASE RELA","Mycobacterium tuberculosis",4,"LEU A 188;VAL A 184;VAL A  60;ASP A 145","None;None;None; MG A 401 (-3.7A)","1.15A","1uyuA-5xnxA:undetectable","1uyuA-5xnxA:21.75"],["1UYU_B_CAMB1416_0","CYTOCHROME P450-CAM","5xnx","BIFUNCTIONAL (P)PPGPP SYNTHASE\/HYDROLASE RELA","Mycobacterium tuberculosis",4,"LEU A 188;VAL A 184;VAL A  60;ASP A 145","None;None;None; MG A 401 (-3.7A)","1.18A","1uyuB-5xnxA:undetectable","1uyuB-5xnxA:21.75"],["3CZV_A_AZMA263_1","CARBONIC ANHYDRASE 13;CARBONIC ANHYDRASE 13","5xnx","BIFUNCTIONAL (P)PPGPP SYNTHASE\/HYDROLASE RELA","Mycobacterium tuberculosis",5,"HIS A 287;VAL A 285;THR A 314;VAL A 326;VAL A 239","None","1.22A","3czvA-5xnxA:undetectable;3czvB-5xnxA:undetectable","3czvA-5xnxA:22.93;3czvB-5xnxA:22.93"],["4L4E_A_CAMA503_0","CAMPHOR 5-MONOOXYGENASE","5xnx","BIFUNCTIONAL (P)PPGPP SYNTHASE\/HYDROLASE RELA","Mycobacterium tuberculosis",4,"LEU A 188;VAL A 184;VAL A  60;ASP A 145","None;None;None; MG A 401 (-3.7A)","1.16A","4l4eA-5xnxA:undetectable","4l4eA-5xnxA:22.20"]]