SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xnz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 ILE A  54
ALA A  57
ALA A  58
LEU A  30
ALA A  89
 None
 0.94A 1fm9A-5xnzA:
undetectable		 1fm9A-5xnzA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 4 LEU A 188
PRO A 189
LEU A 229
ARG A 121
 None
None
None
FUM  A 502 (-3.9A)
 1.39A 1hrkB-5xnzA:
undetectable		 1hrkB-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 ILE A  54
ALA A  57
ALA A  58
LEU A  30
ALA A  89
 None
 0.93A 1k74A-5xnzA:
undetectable		 1k74A-5xnzA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 5xnz CRED
(Streptomyces
cremeus) 		6 / 12 ILE A 301
ALA A 254
LEU A 130
LEU A 137
ILE A 260
THR A 344
 None
 1.40A 1rb2B-5xnzA:
undetectable		 1rb2B-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 8 GLY A 374
ILE A 376
VAL A 377
PRO A 437
 None
 0.98A 1rxcB-5xnzA:
undetectable		 1rxcB-5xnzA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 7 GLY A 374
ILE A 376
VAL A 377
PRO A 437
 None
 0.77A 1rxcC-5xnzA:
undetectable		 1rxcC-5xnzA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 7 GLY A 374
ILE A 376
VAL A 377
PRO A 437
 None
 0.85A 1rxcD-5xnzA:
undetectable		 1rxcD-5xnzA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 8 GLY A 374
ILE A 376
VAL A 377
PRO A 437
 None
 0.91A 1rxcE-5xnzA:
undetectable		 1rxcE-5xnzA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 7 GLY A 374
ILE A 376
VAL A 377
PRO A 437
 None
 1.03A 1rxcF-5xnzA:
undetectable		 1rxcF-5xnzA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 8 GLY A 374
ILE A 376
VAL A 377
PRO A 437
 None
 0.97A 1rxcK-5xnzA:
undetectable		 1rxcK-5xnzA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 7 GLY A 374
ILE A 376
VAL A 377
PRO A 437
 None
 1.01A 1rxcL-5xnzA:
undetectable		 1rxcL-5xnzA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 ILE A  54
ALA A  57
ALA A  58
LEU A  30
ALA A  89
 None
 0.92A 1xiuB-5xnzA:
undetectable		 1xiuB-5xnzA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 ILE A  54
ALA A  57
ALA A  58
LEU A  30
ALA A  89
 None
 0.91A 1xlsA-5xnzA:
undetectable		 1xlsA-5xnzA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 ILE A  54
ALA A  57
ALA A  58
LEU A  30
ALA A  89
 None
 0.91A 1xlsB-5xnzA:
undetectable		 1xlsB-5xnzA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 ILE A  54
ALA A  57
ALA A  58
LEU A  30
ALA A  89
 None
 0.91A 1xlsC-5xnzA:
undetectable		 1xlsC-5xnzA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 ILE A  54
ALA A  57
ALA A  58
LEU A  30
ALA A  89
 None
 0.91A 1xlsD-5xnzA:
undetectable		 1xlsD-5xnzA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 LEU A 111
ASN A  77
ALA A  72
LEU A  65
MET A  29
 None
 1.43A 1ya3A-5xnzA:
undetectable		 1ya3A-5xnzA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 11 ILE A  54
ALA A  57
ALA A  58
LEU A  30
ALA A  89
 None
 0.96A 2aclE-5xnzA:
undetectable		 2aclE-5xnzA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 ILE A  54
ALA A  57
ALA A  58
LEU A  30
ALA A  89
 None
 0.90A 2aclG-5xnzA:
undetectable		 2aclG-5xnzA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 11 ALA A  34
ALA A  58
LEU A  86
ALA A  89
VAL A 101
 None
 1.09A 2bxeB-5xnzA:
undetectable		 2bxeB-5xnzA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 5xnz CRED
(Streptomyces
cremeus) 		6 / 12 ILE A 301
ALA A 254
LEU A 130
LEU A 137
ILE A 260
THR A 344
 None
 1.40A 2d0kA-5xnzA:
undetectable		 2d0kA-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 4 LEU A 188
PRO A 189
LEU A 229
ARG A 121
 None
None
None
FUM  A 502 (-3.9A)
 1.36A 2hrcB-5xnzA:
undetectable		 2hrcB-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 8 SER A 105
VAL A  83
TYR A 202
ASN A  77
 None
 1.19A 2wekA-5xnzA:
undetectable		 2wekA-5xnzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 8 SER A 105
VAL A  83
TYR A 202
ASN A  77
 None
 1.20A 2wekB-5xnzA:
undetectable		 2wekB-5xnzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 THR A 253
ILE A 301
GLY A 345
ALA A 305
ALA A 122
 None
 1.11A 2yvlD-5xnzA:
undetectable		 2yvlD-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 9 ALA A 304
VAL A 308
GLY A 258
GLY A 255
ALA A 347
 None
 0.90A 2z0yB-5xnzA:
undetectable		 2z0yB-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 LEU A 434
VAL A 381
SER A 380
VAL A 425
LEU A 419
 None
 1.41A 2zlcA-5xnzA:
undetectable		 2zlcA-5xnzA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 5 ASP A 131
ARG A 185
ILE A 126
VAL A 249
 None
FUM  A 502 (-3.2A)
None
None
 1.23A 3eigA-5xnzA:
undetectable		 3eigA-5xnzA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 8 ALA A 367
ASN A 368
ARG A 152
PRO A 148
 None
 0.95A 3fxrA-5xnzA:
1.3		 3fxrA-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 7 GLN A 108
LEU A 229
VAL A 118
LEU A 246
 None
 0.94A 3g8iA-5xnzA:
1.3		 3g8iA-5xnzA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 PHE A 163
GLY A 164
GLY A 357
ALA A 356
LEU A 137
 None
 0.73A 3hs6B-5xnzA:
undetectable		 3hs6B-5xnzA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 ILE A 126
GLY A 127
ALA A 134
ALA A 182
VAL A 181
 None
 1.06A 3jb3A-5xnzA:
undetectable		 3jb3A-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 ALA A 451
TRP A 170
LEU A 267
LEU A 165
GLY A 164
 None
 1.15A 3k2hA-5xnzA:
undetectable		 3k2hA-5xnzA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 ALA A 451
TRP A 170
LEU A 267
LEU A 165
GLY A 164
 None
 1.16A 3k2hB-5xnzA:
undetectable		 3k2hB-5xnzA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 5xnz CRED
(Streptomyces
cremeus) 		3 / 3 THR A 106
SER A 107
ARG A 325
 None
 0.72A 3phnA-5xnzA:
undetectable		 3phnA-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 LEU A 111
ASN A  77
ALA A  72
LEU A  65
MET A  29
 None
 1.48A 3vhuA-5xnzA:
undetectable		 3vhuA-5xnzA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 8 GLY A 374
ILE A 376
VAL A 377
PRO A 437
 None
 0.97A 4e1vA-5xnzA:
undetectable		 4e1vA-5xnzA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 7 GLY A 374
ILE A 376
VAL A 377
PRO A 437
 None
 0.91A 4e1vB-5xnzA:
undetectable		 4e1vB-5xnzA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 8 GLY A 374
ILE A 376
VAL A 377
PRO A 437
 None
 0.91A 4e1vC-5xnzA:
undetectable		 4e1vC-5xnzA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 8 GLY A 374
ILE A 376
VAL A 377
PRO A 437
 None
 0.90A 4e1vD-5xnzA:
undetectable		 4e1vD-5xnzA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 8 GLY A 374
ILE A 376
VAL A 377
PRO A 437
 None
 0.93A 4e1vE-5xnzA:
undetectable		 4e1vE-5xnzA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 8 GLY A 374
ILE A 376
VAL A 377
PRO A 437
 None
 0.94A 4e1vG-5xnzA:
undetectable		 4e1vG-5xnzA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 8 GLY A 374
ILE A 376
VAL A 377
PRO A 437
 None
 0.88A 4e1vH-5xnzA:
undetectable		 4e1vH-5xnzA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 11 PHE A 163
ALA A 139
ALA A 141
ALA A 138
VAL A 174
 None
 1.14A 4jbtB-5xnzA:
undetectable		 4jbtB-5xnzA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 9 TRP A 236
VAL A 243
ALA A 244
THR A 316
ALA A 329
 None
 1.19A 4oqrA-5xnzA:
undetectable		 4oqrA-5xnzA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 11 ILE A 301
ALA A 254
LEU A 130
LEU A 137
ILE A 260
 None
 1.11A 4p66A-5xnzA:
undetectable		 4p66A-5xnzA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 11 SER A 380
GLY A 442
THR A 441
ALA A 440
ASP A 436
 None
 1.49A 4qvnH-5xnzA:
undetectable
4qvnI-5xnzA:
undetectable		 4qvnH-5xnzA:
15.09
4qvnI-5xnzA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 10 SER A 380
GLY A 442
THR A 441
ALA A 440
ASP A 436
 None
 1.47A 4qvnV-5xnzA:
undetectable
4qvnW-5xnzA:
0.5		 4qvnV-5xnzA:
15.09
4qvnW-5xnzA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 11 SER A 380
GLY A 442
THR A 441
ALA A 440
ASP A 436
 None
 1.49A 4qvqH-5xnzA:
undetectable
4qvqI-5xnzA:
undetectable		 4qvqH-5xnzA:
15.09
4qvqI-5xnzA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 11 SER A 380
GLY A 442
THR A 441
ALA A 440
ASP A 436
 None
 1.48A 4qvqV-5xnzA:
undetectable
4qvqW-5xnzA:
0.5		 4qvqV-5xnzA:
15.09
4qvqW-5xnzA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 11 THR A  14
GLN A 307
GLY A 345
THR A 344
ALA A 347
 None
 1.19A 4qw0H-5xnzA:
undetectable
4qw0I-5xnzA:
undetectable		 4qw0H-5xnzA:
15.09
4qw0I-5xnzA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 11 THR A  14
GLN A 307
GLY A 345
THR A 344
ALA A 347
 None
 1.19A 4qw0V-5xnzA:
undetectable
4qw0W-5xnzA:
undetectable		 4qw0V-5xnzA:
15.09
4qw0W-5xnzA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 11 SER A 380
GLY A 442
THR A 441
ALA A 440
ASP A 436
 None
 1.48A 4qwuH-5xnzA:
undetectable
4qwuI-5xnzA:
undetectable		 4qwuH-5xnzA:
15.09
4qwuI-5xnzA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 11 SER A 380
GLY A 442
THR A 441
ALA A 440
ASP A 436
 None
 1.47A 4qwuV-5xnzA:
0.0
4qwuW-5xnzA:
0.4		 4qwuV-5xnzA:
15.09
4qwuW-5xnzA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSH_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 5 ARG A 152
LEU A 267
ASN A 368
VAL A 272
 None
 1.49A 5cshB-5xnzA:
undetectable		 5cshB-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 9 LEU A 435
GLY A 374
LEU A 412
LEU A 398
ALA A 402
 None
 1.10A 5dqfA-5xnzA:
undetectable		 5dqfA-5xnzA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 GLY A 390
VAL A 425
VAL A 383
ALA A 382
LEU A 385
 None
 1.10A 5kocA-5xnzA:
undetectable		 5kocA-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 5xnz CRED
(Streptomyces
cremeus) 		6 / 11 ALA A 254
THR A 253
VAL A 308
GLY A 345
GLY A 346
ALA A 347
 None
 1.42A 5lf7K-5xnzA:
undetectable
5lf7L-5xnzA:
undetectable		 5lf7K-5xnzA:
undetectable
5lf7L-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 5xnz CRED
(Streptomyces
cremeus) 		6 / 11 ALA A 254
THR A 253
VAL A 308
GLY A 345
GLY A 346
ALA A 347
 None
 1.43A 5lf7Y-5xnzA:
undetectable
5lf7Z-5xnzA:
undetectable		 5lf7Y-5xnzA:
undetectable
5lf7Z-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 5 ARG A 152
LEU A 267
ASN A 368
VAL A 272
 None
 1.48A 5os7B-5xnzA:
undetectable		 5os7B-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 5 HIS A 237
ALA A 195
GLY A 193
TYR A 202
 None
 1.29A 5yodB-5xnzA:
undetectable		 5yodB-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 5 HIS A 237
ALA A 195
GLY A 193
TYR A 202
 None
 1.24A 5yodD-5xnzA:
undetectable		 5yodD-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 ILE A  54
ALA A  57
ALA A  58
LEU A  30
ALA A  89
 None
 0.97A 5z12B-5xnzA:
undetectable		 5z12B-5xnzA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 ILE A  54
ALA A  57
ALA A  58
LEU A  30
ALA A  89
 None
 0.92A 6a60D-5xnzA:
undetectable		 6a60D-5xnzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5xnz CRED
(Streptomyces
cremeus) 		5 / 12 ASP A 131
ARG A 349
ALA A 348
GLY A 127
VAL A  16
 None
 1.03A 6clxA-5xnzA:
undetectable		 6clxA-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 7 ALA A 136
ASP A 263
ILE A 260
ILE A 301
 None
 0.97A 6fbnA-5xnzA:
undetectable		 6fbnA-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5xnz CRED
(Streptomyces
cremeus) 		4 / 5 ARG A 152
LEU A 267
ASN A 368
VAL A 272
 None
 1.48A 6gmdA-5xnzA:
undetectable		 6gmdA-5xnzA:
undetectable