SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xoc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 5xoc THIOREDOXIN
1,FORKHEAD BOX
PROTEIN H1
(Escherichia
coli;
Homo
sapiens) 		4 / 4 LYS B 293
LEU B 291
ALA B 233
LEU B 235
 None
 0.93A 1f86B-5xocB:
undetectable		 1f86B-5xocB:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5xoc THIOREDOXIN
1,FORKHEAD BOX
PROTEIN H1
(Escherichia
coli;
Homo
sapiens) 		4 / 7 PHE B 313
LEU B 291
LEU B 264
LEU B 235
 None
 0.81A 3bgdB-5xocB:
undetectable		 3bgdB-5xocB:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 5xoc THIOREDOXIN
1,FORKHEAD BOX
PROTEIN H1
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ASN B 294
ALA B 233
LEU B 314
ASN B 317
LEU B 318
 None
 1.18A 3o02A-5xocB:
undetectable
3o02B-5xocB:
undetectable		 3o02A-5xocB:
11.04
3o02B-5xocB:
11.04