SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xoe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		4 / 5 LEU A 265
LEU A 269
LEU A 276
GLY A 287
 None
 1.04A 1a4lC-5xoeA:
undetectable		 1a4lC-5xoeA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		4 / 7 GLY A 271
ALA A 273
TYR A 272
GLU A 281
 None
 0.85A 1dmaA-5xoeA:
undetectable		 1dmaA-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 12 ALA A 109
ILE A 112
PHE A 298
LEU A 277
LEU A   7
 None
 1.17A 1dtlA-5xoeA:
undetectable		 1dtlA-5xoeA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 12 ILE A 124
THR A 135
ILE A 288
LEU A 265
TYR A 106
 None
 1.11A 1dyiA-5xoeA:
undetectable		 1dyiA-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 10 ARG A 268
GLY A 140
ASP A 129
GLY A 101
ILE A 100
 None
 1.05A 1sh9B-5xoeA:
undetectable		 1sh9B-5xoeA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 12 LEU A 276
ASP A 275
VAL A 274
MET A  16
SER A  13
 None
 1.11A 1zq9A-5xoeA:
undetectable		 1zq9A-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 12 PHE A 137
ALA A 170
ALA A 144
ALA A 223
GLY A 183
 None
 1.09A 2igtA-5xoeA:
undetectable		 2igtA-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 12 PHE A 137
ALA A 170
ALA A 144
ALA A 223
GLY A 183
 None
 1.07A 2igtB-5xoeA:
undetectable		 2igtB-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 11 ALA A 266
LEU A 269
PRO A 125
GLY A 126
SER A  13
 None
 0.95A 3bpxA-5xoeA:
undetectable
3bpxB-5xoeA:
undetectable		 3bpxA-5xoeA:
20.33
3bpxB-5xoeA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 11 VAL A  98
ILE A  32
ALA A 273
ALA A  22
THR A  26
 None
 1.03A 3mdtB-5xoeA:
undetectable		 3mdtB-5xoeA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 12 GLY A 140
ASP A 129
GLY A 101
ILE A 100
ALA A 266
 None
 0.78A 3n3iA-5xoeA:
undetectable		 3n3iA-5xoeA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 11 LEU A  97
TYR A  41
ILE A  49
GLY A  43
LEU A  68
 None
 1.19A 3n8yA-5xoeA:
undetectable		 3n8yA-5xoeA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		4 / 5 TYR A 106
VAL A  99
SER A 105
GLY A 126
 None
 1.40A 3v4tA-5xoeA:
undetectable
3v4tD-5xoeA:
undetectable		 3v4tA-5xoeA:
undetectable
3v4tD-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		3 / 3 ASP A 153
LYS A 154
ASP A 157
 None
 0.63A 4a7tA-5xoeA:
undetectable		 4a7tA-5xoeA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 12 ILE A  32
ALA A 273
ALA A  22
ALA A  27
THR A  26
 None
 1.10A 4enhA-5xoeA:
undetectable		 4enhA-5xoeA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 12 VAL A  20
GLY A 126
SER A 267
GLY A 270
THR A   8
 None
 1.16A 4mm8A-5xoeA:
undetectable		 4mm8A-5xoeA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		3 / 3 ASN A 290
ASP A 136
ASP A 310
 None
 0.83A 4obwD-5xoeA:
undetectable		 4obwD-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 9 ALA A  19
ALA A  18
GLY A 101
GLY A 126
ASP A 262
 None
 1.12A 4qwuK-5xoeA:
undetectable
4qwuL-5xoeA:
undetectable		 4qwuK-5xoeA:
17.16
4qwuL-5xoeA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 12 LEU A 276
ALA A   5
ILE A   4
ILE A 100
GLY A 271
 None
 1.01A 4r3aB-5xoeA:
undetectable		 4r3aB-5xoeA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		4 / 4 THR A   8
GLY A  43
ASP A  48
SER A  70
 None
 1.38A 4rfqA-5xoeA:
undetectable		 4rfqA-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 12 ILE A 124
THR A 135
ILE A 288
LEU A 265
TYR A 106
 None
 1.14A 4x5hA-5xoeA:
undetectable		 4x5hA-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 12 ILE A 124
THR A 135
ILE A 288
LEU A 265
TYR A 106
 None
 1.11A 5eajB-5xoeA:
2.1		 5eajB-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		3 / 3 ALA A  85
ASN A  88
LEU A  89
 None
 0.35A 5i1nB-5xoeA:
undetectable		 5i1nB-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		4 / 7 GLY A 140
ASP A 129
GLY A 101
ILE A 100
 None
 0.69A 5kqyB-5xoeA:
undetectable		 5kqyB-5xoeA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 10 ILE A 288
LEU A 265
ILE A 124
ILE A 139
ILE A 132
 None
 0.88A 5mvmD-5xoeA:
undetectable
5mvmE-5xoeA:
undetectable		 5mvmD-5xoeA:
25.61
5mvmE-5xoeA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		3 / 3 VAL A  37
LYS A   3
MET A   1
 None
 1.05A 5nknA-5xoeA:
undetectable		 5nknA-5xoeA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E
(Staphylococcus
aureus) 		5 / 12 ILE A 124
THR A 135
ILE A 288
LEU A 265
TYR A 106
 None
 1.09A 5ujxB-5xoeA:
2.1		 5ujxB-5xoeA:
undetectable