SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xog'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 GLU B 694
ILE B 609
ARG B 398
 None
 0.85A 1cd2A-5xogB:
undetectable		 1cd2A-5xogB:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 8 MET A 606
VAL A 532
GLY A 629
LEU A 589
 None
 0.86A 1dzmA-5xogA:
undetectable		 1dzmA-5xogA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 5 LYS A 844
ALA A 845
ASP A 848
GLY A1067
 None
 1.20A 1e7cA-5xogA:
3.1		 1e7cA-5xogA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 5 ALA A1071
ALA A 845
LYS A 844
GLU A 847
 None
 1.08A 1e7cA-5xogA:
3.1		 1e7cA-5xogA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 LEU B 354
PHE B 574
GLY B 577
GLY B 581
LEU B 559
 None
 1.06A 1fe2A-5xogB:
0.0		 1fe2A-5xogB:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 ILE A1074
ALA A1071
ALA A1070
LEU A1373
LEU A 842
 None
 0.97A 1fm9A-5xogA:
undetectable		 1fm9A-5xogA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 MET A 819
SER A 784
ALA A 777
ILE A 776
 None
 0.96A 1fxhA-5xogA:
undetectable
1fxhB-5xogA:
2.6		 1fxhA-5xogA:
8.53
1fxhB-5xogA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 4 GLY B 395
ASP B 691
GLY B 624
THR B 491
 None
 0.99A 1hxbB-5xogB:
undetectable		 1hxbB-5xogB:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 LEU B 354
PHE B 574
GLY B 577
GLY B 581
LEU B 559
 None
 1.11A 1igxA-5xogB:
undetectable		 1igxA-5xogB:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 ILE A1074
ALA A1071
ALA A1070
LEU A1373
LEU A 842
 None
 0.97A 1k74A-5xogA:
undetectable		 1k74A-5xogA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ILE B 247
ALA B 229
LEU B 378
VAL B 277
LEU B 354
 None
 0.97A 1k74A-5xogB:
undetectable		 1k74A-5xogB:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		5 / 12 GLY A  82
ASP A  55
ALA B1209
GLY A  59
LEU B1202
 None
None
None
ZN  A1801 ( 4.4A)
None
 1.03A 1kiaC-5xogA:
undetectable		 1kiaC-5xogA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE II
SUBUNIT B12.5
(Komagataella
phaffii) 		5 / 12 ILE B1011
HIS A 660
LEU B1081
VAL K  63
TYR K  61
 None
 1.35A 1mrlB-5xogB:
undetectable
1mrlC-5xogB:
undetectable		 1mrlB-5xogB:
11.13
1mrlC-5xogB:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5xog RNA POLYMERASE
SUBUNIT ABC10-ALPHA
(Komagataella
phaffii) 		4 / 5 LEU L  42
CYH L  33
ALA L  35
CYH L  36
 None
ZN  L 101 (-2.6A)
None
ZN  L 101 (-2.4A)
 0.95A 1mz9D-5xogL:
undetectable		 1mz9D-5xogL:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 5 HIS A1370
ARG A1369
ILE A 512
HIS A 452
 None
 1.28A 1osvB-5xogA:
undetectable		 1osvB-5xogA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 THR A 789
PHE A 778
PHE A 793
VAL A 719
PHE A 715
 None
 1.38A 1q23C-5xogA:
undetectable		 1q23C-5xogA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5xog RNA POLYMERASE II
SUBUNIT B12.5
RNA POLYMERASE
SUBUNIT ABC10-ALPHA
SPT4/5 COMPLEX
COMPONENT
(Komagataella
phaffii;
Komagataella
phaffii;
Komagataella
phaffii) 		4 / 6 ARG W 777
ASP K   5
ASP L  70
ASN W 784
 None
 1.30A 1rjdA-5xogW:
undetectable		 1rjdA-5xogW:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5xog RNA POLYMERASE II
SUBUNIT B12.5
RNA POLYMERASE
SUBUNIT ABC10-ALPHA
SPT4/5 COMPLEX
COMPONENT
(Komagataella
phaffii;
Komagataella
phaffii;
Komagataella
phaffii) 		4 / 6 ARG W 777
ASP K   5
ASP L  70
ASN W 784
 None
 1.28A 1rjdB-5xogW:
undetectable		 1rjdB-5xogW:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5xog RNA POLYMERASE II
SUBUNIT B12.5
RNA POLYMERASE
SUBUNIT ABC10-ALPHA
SPT4/5 COMPLEX
COMPONENT
(Komagataella
phaffii;
Komagataella
phaffii;
Komagataella
phaffii) 		4 / 6 ARG W 777
ASP K   5
ASP L  70
ASN W 784
 None
 1.29A 1rjdC-5xogW:
undetectable		 1rjdC-5xogW:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 8 SER A 664
GLN B1065
PHE B1086
ASN A 743
 None
 1.36A 1rs6A-5xogA:
undetectable		 1rs6A-5xogA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 ILE A1033
GLY A 991
ILE A 989
VAL A1047
PHE A1037
 None
 1.25A 1sg9A-5xogA:
undetectable		 1sg9A-5xogA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 5xog RNA POLYMERASE II
SUBUNIT B32
(Komagataella
phaffii) 		4 / 5 ASP D  86
THR D 105
LEU D 109
LEU D 106
 None
 1.00A 1u18B-5xogD:
undetectable		 1u18B-5xogD:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 8 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.82A 1v54P-5xogA:
3.9
1v54W-5xogA:
undetectable		 1v54P-5xogA:
9.55
1v54W-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.86A 1v55C-5xogA:
2.8
1v55J-5xogA:
undetectable		 1v55C-5xogA:
9.55
1v55J-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ILE B 247
ALA B 229
LEU B 378
VAL B 277
LEU B 354
 None
 1.08A 1xdkA-5xogB:
undetectable		 1xdkA-5xogB:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ILE B 247
ALA B 229
LEU B 378
VAL B 277
LEU B 354
 None
 0.99A 1xiuA-5xogB:
undetectable		 1xiuA-5xogB:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 ILE A1074
ALA A1071
ALA A1070
LEU A1373
LEU A 842
 None
 0.94A 1xlsA-5xogA:
undetectable		 1xlsA-5xogA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 ILE A1074
ALA A1071
ALA A1070
LEU A1373
LEU A 842
 None
 0.94A 1xlsB-5xogA:
undetectable		 1xlsB-5xogA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 ILE A1074
ALA A1071
ALA A1070
LEU A1373
LEU A 842
 None
 0.94A 1xlsC-5xogA:
undetectable		 1xlsC-5xogA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 ILE A1074
ALA A1071
ALA A1070
LEU A1373
LEU A 842
 None
 0.94A 1xlsD-5xogA:
undetectable		 1xlsD-5xogA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ILE B1212
ALA B1213
ARG B1215
HIS A  92
PHE A  95
 None
 1.32A 1y0xX-5xogB:
undetectable		 1y0xX-5xogB:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 4 GLY B 460
SER B 468
VAL B 472
LEU B 409
 None
 1.32A 1yajB-5xogB:
undetectable		 1yajB-5xogB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 6 LEU B 379
LEU B 383
CYH B 309
LEU B 290
 None
 0.84A 2ab2A-5xogB:
undetectable		 2ab2A-5xogB:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 7 PHE B 325
GLN B 270
TYR B 250
GLU B 312
 None
 1.47A 2aowA-5xogB:
undetectable		 2aowA-5xogB:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 11 LEU A 375
ILE A 371
VAL A 365
GLY A 366
LEU A 490
 None
 1.41A 2bxeA-5xogA:
4.2		 2bxeA-5xogA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 LEU A1023
TYR A 898
VAL A 992
CYH A 996
ARG A1027
 None
 1.27A 2bxfB-5xogA:
2.4		 2bxfB-5xogA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 5 TRP B 512
GLY B 692
LEU B 630
PRO A 786
 None
 1.26A 2dqyA-5xogB:
undetectable		 2dqyA-5xogB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 8 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.82A 2dyrP-5xogA:
3.9
2dyrW-5xogA:
undetectable		 2dyrP-5xogA:
9.55
2dyrW-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.82A 2dysP-5xogA:
4.0
2dysW-5xogA:
undetectable		 2dysP-5xogA:
9.55
2dysW-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.85A 2eijC-5xogA:
2.8
2eijJ-5xogA:
undetectable		 2eijC-5xogA:
9.55
2eijJ-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.86A 2eikC-5xogA:
3.9
2eikJ-5xogA:
undetectable		 2eikC-5xogA:
9.55
2eikJ-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 8 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.83A 2eikP-5xogA:
3.9
2eikW-5xogA:
undetectable		 2eikP-5xogA:
9.55
2eikW-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 8 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.84A 2eilC-5xogA:
4.0
2eilJ-5xogA:
undetectable		 2eilC-5xogA:
9.55
2eilJ-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.85A 2eimC-5xogA:
3.9
2eimJ-5xogA:
undetectable		 2eimC-5xogA:
9.55
2eimJ-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.90A 2einC-5xogA:
3.9
2einJ-5xogA:
undetectable		 2einC-5xogA:
9.55
2einJ-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 6 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.77A 2einP-5xogA:
3.9
2einW-5xogA:
undetectable		 2einP-5xogA:
9.55
2einW-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		5 / 12 PHE A 445
VAL A 367
ALA B1107
PHE A 348
VAL A 443
 None
 1.46A 2g70B-5xogA:
undetectable		 2g70B-5xogA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ILE B 247
ALA B 229
ALA B 382
LEU B 249
LEU B 306
 None
 0.89A 2h77A-5xogB:
undetectable		 2h77A-5xogB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ILE B 247
ALA B 229
ALA B 382
LEU B 249
LEU B 306
 None
 0.91A 2h79A-5xogB:
undetectable		 2h79A-5xogB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 SER A1364
PRO A1077
VAL A1366
LEU A1107
 None
 1.04A 2hdnE-5xogA:
undetectable
2hdnF-5xogA:
2.2
2hdnH-5xogA:
2.2		 2hdnE-5xogA:
2.50
2hdnF-5xogA:
12.56
2hdnH-5xogA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 VAL A1366
LEU A1107
SER A1364
PRO A1077
 None
 1.04A 2hdnF-5xogA:
2.2
2hdnG-5xogA:
undetectable
2hdnH-5xogA:
2.2		 2hdnF-5xogA:
12.56
2hdnG-5xogA:
2.50
2hdnH-5xogA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 7 GLU B1132
MET B1152
ARG B1135
GLY A 343
 None
 0.96A 2hs1B-5xogB:
undetectable		 2hs1B-5xogB:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 9 GLU A1167
GLU A1153
LYS A1237
GLU A1198
ILE A1239
 None
 1.37A 2j9dA-5xogA:
4.1
2j9dB-5xogA:
4.1
2j9dC-5xogA:
3.4		 2j9dA-5xogA:
6.28
2j9dB-5xogA:
6.28
2j9dC-5xogA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 9 LYS A1237
GLU A1198
ILE A1239
GLU A1167
GLU A1153
 None
 1.34A 2j9dA-5xogA:
4.1
2j9dB-5xogA:
4.1
2j9dC-5xogA:
3.4		 2j9dA-5xogA:
6.28
2j9dB-5xogA:
6.28
2j9dC-5xogA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 10 LYS A1237
GLU A1198
ILE A1239
GLU A1167
GLU A1153
 None
 1.32A 2j9dD-5xogA:
2.3
2j9dE-5xogA:
undetectable
2j9dF-5xogA:
4.2		 2j9dD-5xogA:
6.28
2j9dE-5xogA:
5.43
2j9dF-5xogA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_H_ACTH1113_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 9 GLU A1153
LYS A1237
GLU A1198
ILE A1239
GLU A1167
 None
 1.39A 2j9dG-5xogA:
4.1
2j9dH-5xogA:
2.3
2j9dI-5xogA:
3.2		 2j9dG-5xogA:
6.28
2j9dH-5xogA:
6.28
2j9dI-5xogA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_H_ACTH1113_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 9 GLU A1167
GLU A1153
LYS A1237
GLU A1198
ILE A1239
 None
 1.36A 2j9dG-5xogA:
4.1
2j9dH-5xogA:
2.3
2j9dI-5xogA:
3.2		 2j9dG-5xogA:
6.28
2j9dH-5xogA:
6.28
2j9dI-5xogA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 8 GLU A1153
LYS A1237
GLU A1198
ILE A1239
GLU A1167
 None
 1.35A 2j9dJ-5xogA:
2.5
2j9dK-5xogA:
2.4
2j9dL-5xogA:
1.9		 2j9dJ-5xogA:
6.28
2j9dK-5xogA:
6.28
2j9dL-5xogA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 8 LYS A1237
GLU A1198
ILE A1239
GLU A1167
GLU A1153
 None
 1.34A 2j9dJ-5xogA:
2.5
2j9dK-5xogA:
2.4
2j9dL-5xogA:
1.9		 2j9dJ-5xogA:
6.28
2j9dK-5xogA:
6.28
2j9dL-5xogA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		3 / 3 ASP C 220
TYR C 221
LYS A 570
 None
 1.18A 2othA-5xogC:
undetectable		 2othA-5xogC:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 4 SER C 237
GLY C 236
HIS B 996
ASP B1009
 None
 1.23A 2oxtC-5xogC:
undetectable		 2oxtC-5xogC:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
TRANSCRIPTION
ELONGATION FACTOR 1
HOMOLOG
(Komagataella
pastoris;
Komagataella
phaffii) 		5 / 12 ILE B 342
ASP B 324
ARG B 328
ASP M  72
ALA M  76
 None
 1.29A 2qmjA-5xogB:
undetectable		 2qmjA-5xogB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 7 GLY B  80
PHE B 414
ILE B 158
PHE B 410
 None
 1.04A 2qmzA-5xogB:
undetectable
2qmzB-5xogB:
undetectable		 2qmzA-5xogB:
10.57
2qmzB-5xogB:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 PHE A 800
THR A 722
ALA A 726
ILE A 694
ILE A 695
 None
 0.93A 2rlcA-5xogA:
undetectable		 2rlcA-5xogA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 6 ILE A1355
ARG A1102
LEU A1103
LEU A1351
 None
 1.08A 2rlfA-5xogA:
undetectable
2rlfD-5xogA:
undetectable		 2rlfA-5xogA:
2.26
2rlfD-5xogA:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 5xog RNA POLYMERASE II
SUBUNIT B32
(Komagataella
phaffii) 		4 / 6 ILE D  60
ARG D  61
LEU D 109
LEU D  64
 None
 1.05A 2rlfA-5xogD:
undetectable
2rlfD-5xogD:
undetectable		 2rlfA-5xogD:
15.50
2rlfD-5xogD:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE II
SUBUNIT B32
(Komagataella
phaffii) 		3 / 3 ARG D  13
GLU A  26
SER B1221
 None
 0.86A 2xctD-5xogD:
undetectable		 2xctD-5xogD:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 HIS A 588
ASN A 968
PRO A 584
THR A 633
VAL A 634
 None
 1.26A 2xrlA-5xogA:
3.5		 2xrlA-5xogA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 THR A1330
VAL A1120
LEU A1122
ILE A1136
SER A1139
 None
 1.18A 2xrlA-5xogA:
3.5		 2xrlA-5xogA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 8 GLN B  34
ASP B  39
TYR B 193
CYH B 170
 None
 1.21A 2xz5A-5xogB:
undetectable
2xz5C-5xogB:
undetectable		 2xz5A-5xogB:
11.35
2xz5C-5xogB:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 8 GLN B  34
ASP B  39
TYR B 193
CYH B 170
 None
 1.24A 2xz5C-5xogB:
undetectable
2xz5D-5xogB:
undetectable		 2xz5C-5xogB:
11.35
2xz5D-5xogB:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 5 GLN B1065
THR B1090
HIS B1025
LEU B1026
 None
 1.30A 2zj0A-5xogB:
undetectable		 2zj0A-5xogB:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 6 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.84A 2zxwP-5xogA:
3.9
2zxwW-5xogA:
undetectable		 2zxwP-5xogA:
9.55
2zxwW-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 7 ILE B1212
PHE A1413
ARG A 329
MET A 305
 None
 1.07A 2zxwN-5xogB:
undetectable
2zxwW-5xogB:
undetectable		 2zxwN-5xogB:
17.56
2zxwW-5xogB:
4.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE II
SUBUNIT B12.5
(Komagataella
phaffii;
Komagataella
phaffii;
Komagataella
phaffii) 		4 / 8 VAL B 992
ASP A 357
GLY B 832
HIS K  65
 None
 0.88A 3af0A-5xogB:
undetectable		 3af0A-5xogB:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.85A 3ag2C-5xogA:
3.1		 3ag2C-5xogA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.82A 3ag2P-5xogA:
3.9
3ag2W-5xogA:
undetectable		 3ag2P-5xogA:
9.55
3ag2W-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 8 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.84A 3ag4C-5xogA:
3.9
3ag4J-5xogA:
undetectable		 3ag4C-5xogA:
9.55
3ag4J-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.84A 3ag4P-5xogA:
3.9
3ag4W-5xogA:
undetectable		 3ag4P-5xogA:
9.55
3ag4W-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.84A 3asnC-5xogA:
3.9
3asnJ-5xogA:
undetectable		 3asnC-5xogA:
9.55
3asnJ-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 4 LEU B1207
ARG A1402
LEU A1400
ALA A1415
 None
 1.03A 3b9mA-5xogB:
undetectable		 3b9mA-5xogB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 4 SER A  60
GLY A  59
GLY A  73
GLY A  71
 None
ZN  A1801 ( 4.4A)
None
None
 0.90A 3bogB-5xogA:
undetectable
3bogD-5xogA:
undetectable		 3bogB-5xogA:
undetectable
3bogD-5xogA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		3 / 3 GLY B1142
GLY A1063
GLY A1440
 None
 0.38A 3bogD-5xogB:
undetectable		 3bogD-5xogB:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 8 ILE B 687
TRP B 678
PHE B  24
TYR B 689
 None
 0.98A 3ccfB-5xogB:
undetectable		 3ccfB-5xogB:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 5 GLN B1065
THR B1090
HIS B1025
LEU B1026
 None
 1.19A 3ce6A-5xogB:
undetectable		 3ce6A-5xogB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 5 GLN B1065
THR B1090
HIS B1025
LEU B1026
 None
 1.22A 3ce6C-5xogB:
undetectable		 3ce6C-5xogB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ALA B 793
MET B 778
THR B 971
PRO B 974
PHE B 851
 None
 1.30A 3cl9A-5xogB:
undetectable		 3cl9A-5xogB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 4 VAL B 780
ARG B 815
ILE B 755
THR B 783
 None
 1.43A 3cl9A-5xogB:
undetectable		 3cl9A-5xogB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 THR B 571
VAL B 575
VAL B 606
ILE B 608
THR B 621
 None
 1.12A 3czhA-5xogB:
undetectable		 3czhA-5xogB:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 THR B 571
VAL B 575
VAL B 606
ILE B 608
THR B 621
 None
 1.13A 3dl9A-5xogB:
undetectable		 3dl9A-5xogB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ILE B 247
ALA B 229
LEU B 378
VAL B 277
LEU B 354
 None
 1.09A 3dzuA-5xogB:
undetectable		 3dzuA-5xogB:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ILE B 247
ALA B 229
LEU B 378
VAL B 277
LEU B 354
 None
 1.13A 3dzyA-5xogB:
undetectable		 3dzyA-5xogB:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 GLY A1067
HIS A1370
VAL A 851
GLN A 866
 None
 0.90A 3fi0E-5xogA:
undetectable		 3fi0E-5xogA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		4 / 5 ASP C 220
TYR C 221
PRO A 569
LYS A 570
 None
 1.43A 3fo7A-5xogC:
undetectable		 3fo7A-5xogC:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 7 TYR B1040
LEU B1058
VAL B1055
THR B1051
 None
 1.03A 3fwgB-5xogB:
undetectable		 3fwgB-5xogB:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 7 TYR B1040
LEU B1058
VAL B1055
THR B1051
 None
 1.03A 3fwiA-5xogB:
undetectable		 3fwiA-5xogB:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
RNA POLYMERASE II
SUBUNIT B12.5
RNA POLYMERASE
SUBUNIT ABC10-ALPHA
(Komagataella
phaffii;
Komagataella
phaffii;
Komagataella
phaffii) 		3 / 3 ARG K  37
GLU C 166
ASP L  70
 None
 0.67A 3g2oA-5xogK:
undetectable		 3g2oA-5xogK:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 ASN B 822
MET B 778
PHE B 851
 None
 1.10A 3g4lD-5xogB:
undetectable		 3g4lD-5xogB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ILE B 247
ALA B 229
ALA B 382
LEU B 249
LEU B 306
 None
 0.93A 3gwsX-5xogB:
undetectable		 3gwsX-5xogB:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 THR A1030
GLU A1035
LEU A 902
ILE A 920
LEU A 937
 None
 1.32A 3gwxB-5xogA:
undetectable		 3gwxB-5xogA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		5 / 12 LEU C 143
GLY C 141
GLN C 140
LEU C 100
ILE C  69
 None
 1.22A 3h52A-5xogC:
undetectable		 3h52A-5xogC:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 4 LEU A 958
PRO A 959
LEU A1023
ARG A1025
 None
 1.49A 3hcoA-5xogA:
undetectable		 3hcoA-5xogA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 8 VAL A 102
TRP A 139
ILE A 128
GLY A 224
 None
 0.77A 3hjoA-5xogA:
undetectable		 3hjoA-5xogA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 8 VAL A 102
TRP A 139
ILE A 128
GLY A 224
 None
 0.76A 3hjoB-5xogA:
undetectable		 3hjoB-5xogA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
RNA POLYMERASE II
SUBUNIT B12.5
(Komagataella
phaffii) 		5 / 12 ASN K   2
HIS A 400
VAL A 367
VAL A 461
LEU A 375
 None
 1.14A 3hkuA-5xogK:
undetectable		 3hkuA-5xogK:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 ARG B 391
THR B 491
THR B 510
 None
 0.74A 3k2hB-5xogB:
undetectable		 3k2hB-5xogB:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		5 / 12 VAL C 113
LEU C 144
LEU C 147
SER C  63
ILE C 155
 None
 1.00A 3kk6A-5xogC:
undetectable		 3kk6A-5xogC:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		5 / 12 VAL C 113
LEU C 144
LEU C 147
SER C  63
ILE C 155
 None
 0.99A 3kk6B-5xogC:
undetectable		 3kk6B-5xogC:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 GLU B 320
LEU B 323
ASP B 324
 None
 0.45A 3ko0A-5xogB:
undetectable		 3ko0A-5xogB:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 GLU B 320
LEU B 323
ASP B 324
 None
 0.32A 3ko0T-5xogB:
undetectable		 3ko0T-5xogB:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
RNA POLYMERASE
SUBUNIT ABC10-ALPHA
(Komagataella
phaffii) 		5 / 12 GLY B 902
ILE B 948
VAL C  48
ALA C  58
ILE L  67
 None
 1.00A 3n3iA-5xogB:
undetectable		 3n3iA-5xogB:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 6 ILE A 524
PRO A 520
GLY A 629
VAL A 613
 None
 0.93A 3n3iA-5xogA:
undetectable		 3n3iA-5xogA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE
SUBUNIT ABC10-ALPHA
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 8 ARG B 904
GLN L  68
PHE L  69
ASP L  70
 None
 1.30A 3n66B-5xogB:
undetectable		 3n66B-5xogB:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 LEU B 281
HIS B 356
THR B 244
SER B 243
LEU B 349
 None
 1.16A 3okxA-5xogB:
0.5		 3okxA-5xogB:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ALA B 407
GLY B 238
SER B 239
ASP B  48
LEU B  49
 None
 1.22A 3ou6D-5xogB:
undetectable		 3ou6D-5xogB:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ALA B 407
GLY B 238
SER B 239
ASP B  48
LEU B  49
 None
 1.26A 3ou7D-5xogB:
undetectable		 3ou7D-5xogB:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		5 / 12 GLY B1142
ALA A 507
ALA A 458
LEU B1147
LEU A 502
 None
 0.91A 3p2kA-5xogB:
undetectable		 3p2kA-5xogB:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		5 / 12 GLY B1142
ALA A 507
ALA A 458
LEU B1147
LEU A 502
 None
 0.99A 3p2kD-5xogB:
undetectable		 3p2kD-5xogB:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 LEU B1081
ASN A 743
ALA B 828
ALA B 826
LEU A 658
 None
 1.15A 3p5nB-5xogB:
undetectable		 3p5nB-5xogB:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 TYR B 295
TYR B 562
GLU B 616
 None
 0.91A 3pfgA-5xogB:
undetectable		 3pfgA-5xogB:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
RNA POLYMERASE
SUBUNIT ABC10-ALPHA
SPT4/5 COMPLEX
COMPONENT
(Komagataella
phaffii) 		4 / 6 GLN L  68
MET L  66
ILE W 767
SER C  82
 None
 0.93A 3pmzD-5xogL:
undetectable		 3pmzD-5xogL:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE
SUBUNIT ABC10-ALPHA
(Komagataella
phaffii) 		5 / 10 THR B 956
PRO L  47
ARG B 107
GLY L  54
GLY B 960
 None
 1.24A 3pp7B-5xogB:
undetectable		 3pp7B-5xogB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 5xog RNA POLYMERASE II
SUBUNIT B32
(Komagataella
phaffii) 		5 / 12 LEU D  89
LEU D  64
ASN D 110
LEU D 109
LEU D  51
 None
 1.11A 3r9cA-5xogD:
undetectable		 3r9cA-5xogD:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 7 ASP A 486
ASP A 484
GLN A 526
ARG B 766
 MG  A1803 (-2.6A)
MG  A1803 ( 2.2A)
None
APC  A1804 (-3.4A)
 1.18A 3s3oA-5xogA:
undetectable		 3s3oA-5xogA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 9 ASP B1101
GLY B 977
ILE B 976
ILE A 371
ILE B1103
 None
 0.95A 3s56B-5xogB:
undetectable		 3s56B-5xogB:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 6 SER B 679
LEU B 681
HIS B 651
THR B 683
 None
 1.49A 3thrB-5xogB:
undetectable		 3thrB-5xogB:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		4 / 7 ILE C 155
SER C 117
LEU C 147
VAL C 113
 None
 0.82A 3ua5B-5xogC:
undetectable		 3ua5B-5xogC:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		3 / 3 PRO A  48
ASP A  42
GLU A  50
 None
 0.84A 3v4tC-5xogA:
undetectable		 3v4tC-5xogA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
RNA POLYMERASE II
SUBUNIT B12.5
(Komagataella
phaffii;
Komagataella
phaffii) 		3 / 3 LYS C 224
ARG K  47
LEU K  52
 None
 1.27A 3v4tE-5xogC:
undetectable		 3v4tE-5xogC:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.94A 3x2qC-5xogA:
3.1
3x2qJ-5xogA:
undetectable		 3x2qC-5xogA:
9.55
3x2qJ-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.98A 3x2qP-5xogA:
3.9
3x2qW-5xogA:
undetectable		 3x2qP-5xogA:
9.55
3x2qW-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		4 / 5 VAL C   7
LEU C  21
LEU C  19
ILE C 248
 None
 0.94A 4a9jA-5xogC:
undetectable		 4a9jA-5xogC:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		4 / 5 VAL C   7
LEU C  21
LEU C  19
ILE C 248
 None
 0.87A 4a9jB-5xogC:
undetectable		 4a9jB-5xogC:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		4 / 5 VAL C   7
LEU C  21
LEU C  19
ILE C 248
 None
 0.89A 4a9jC-5xogC:
undetectable		 4a9jC-5xogC:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 7 GLY B 888
THR B 889
ILE B 910
THR B 882
 None
 0.94A 4acaC-5xogB:
undetectable		 4acaC-5xogB:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5xog RNA POLYMERASE II
SUBUNIT B12.5
RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		4 / 4 ASN K  96
SER C  31
LEU K  45
THR K 100
 None
 1.20A 4an2A-5xogK:
3.1		 4an2A-5xogK:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 SER B 982
GLY B 820
PHE B 980
CYH B1029
GLU B1028
 None
 1.35A 4bupB-5xogB:
undetectable		 4bupB-5xogB:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 TYR B1073
MET B1072
ILE B 824
 None
 0.88A 4c8bB-5xogB:
undetectable		 4c8bB-5xogB:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		3 / 3 ARG C 227
THR C 208
TRP C 209
 None
 0.91A 4d7hA-5xogC:
undetectable		 4d7hA-5xogC:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
RNA POLYMERASE II
SUBUNIT B12.5
(Komagataella
phaffii) 		5 / 11 ASP K  24
ARG K  26
PHE A 552
VAL K  72
ILE K  33
 None
 1.44A 4dz2A-5xogK:
undetectable
4dz2B-5xogK:
undetectable		 4dz2A-5xogK:
21.01
4dz2B-5xogK:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 5 ARG B 490
VAL B 751
LEU B 485
SER B 482
 G  P   8 ( 4.7A)
None
None
None
 1.33A 4e1gA-5xogB:
undetectable		 4e1gA-5xogB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 11 ILE B 910
ASP B 896
LEU B 898
GLY B 897
ALA B 900
 None
 1.26A 4fogD-5xogB:
undetectable		 4fogD-5xogB:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 5 THR B 447
GLY B 159
VAL B 115
PRO B 114
 None
 1.15A 4grkA-5xogB:
undetectable		 4grkA-5xogB:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 GLY A 629
GLY A 628
GLY A 627
SER A 625
VAL A 618
 None
 0.83A 4htfA-5xogA:
undetectable		 4htfA-5xogA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 GLY A 629
GLY A 628
GLY A 627
SER A 625
VAL A 618
 None
 0.84A 4htfB-5xogA:
undetectable		 4htfB-5xogA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
RNA POLYMERASE II
SUBUNIT B12.5
(Komagataella
phaffii;
Komagataella
phaffii;
Komagataella
phaffii) 		5 / 12 TYR K  53
GLU A 545
SER C  27
LEU K  45
ILE K  94
 None
 1.37A 4k39A-5xogK:
undetectable		 4k39A-5xogK:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 ILE A1074
ALA A1071
ALA A1070
LEU A1373
LEU A 842
 None
 1.00A 4k6iA-5xogA:
undetectable		 4k6iA-5xogA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 7 SER A 664
GLN B1065
PHE B1086
ASN A 743
 None
 1.31A 4kcnB-5xogA:
undetectable		 4kcnB-5xogA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 GLN B 474
HIS B 487
ARG B 490
ARG B 497
PRO B 521
 A  P   7 ( 3.9A)
None
G  P   8 ( 4.7A)
A  P   7 ( 4.9A)
G  P   8 ( 4.9A)
 0.85A 4kmuC-5xogB:
24.7		 4kmuC-5xogB:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ILE B 247
ALA B 229
ALA B 382
LEU B 249
LEU B 306
 None
 0.91A 4lnwA-5xogB:
undetectable		 4lnwA-5xogB:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ILE B 247
ALA B 229
ALA B 382
LEU B 249
LEU B 306
 None
 0.89A 4lnxA-5xogB:
undetectable		 4lnxA-5xogB:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 LEU B1010
GLN B 770
GLN B 986
ILE B1012
ALA B1016
 None
 0.94A 4ltwA-5xogB:
undetectable		 4ltwA-5xogB:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 5 GLN B1065
THR B1090
HIS B1025
LEU B1026
 None
 1.36A 4lvcA-5xogB:
undetectable		 4lvcA-5xogB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 5 GLN B1065
THR B1090
HIS B1025
LEU B1026
 None
 1.35A 4lvcC-5xogB:
undetectable		 4lvcC-5xogB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 ASN B 212
ASP B 622
ASP B 400
 None
 0.81A 4obwD-5xogB:
undetectable		 4obwD-5xogB:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 ASN B 408
ASP B 400
ASP B 622
 None
 0.72A 4obwD-5xogB:
undetectable		 4obwD-5xogB:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
SPT4/5 COMPLEX
COMPONENT
(Komagataella
phaffii) 		3 / 3 ASP C  89
TYR C  90
TRP W 804
 None
 1.12A 4p7nA-5xogC:
undetectable		 4p7nA-5xogC:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 8 LEU A1316
VAL A1120
TYR A1331
LEU A1342
 None
 1.11A 4pwdC-5xogA:
4.5		 4pwdC-5xogA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 8 LEU A1316
VAL A1120
TYR A1331
LEU A1342
 None
 1.13A 4q0bA-5xogA:
4.1		 4q0bA-5xogA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 9 ALA A1016
VAL A 851
GLY A 870
SER A1058
VAL A1060
 None
 1.30A 4r20B-5xogA:
1.8		 4r20B-5xogA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ILE B 158
GLY B 159
PHE B 414
VAL B 115
ILE B  46
 None
 1.05A 4rvdA-5xogB:
undetectable		 4rvdA-5xogB:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ILE B 158
GLY B 159
PHE B 414
VAL B 115
ILE B  46
 None
 1.05A 4rvgA-5xogB:
undetectable		 4rvgA-5xogB:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		3 / 3 ARG C 227
THR C 208
TRP C 209
 None
 0.83A 4ug5A-5xogC:
undetectable		 4ug5A-5xogC:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		3 / 3 ARG C 227
THR C 208
TRP C 209
 None
 0.92A 4uglA-5xogC:
undetectable		 4uglA-5xogC:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 ILE A 985
PRO A 986
ILE A 920
SER A 908
THR A1030
 None
 1.17A 4uroD-5xogA:
undetectable		 4uroD-5xogA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		5 / 12 HIS A 588
ASN A 968
PRO A 584
THR A 633
VAL A 634
 None
 1.23A 4v2gB-5xogA:
undetectable		 4v2gB-5xogA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 4 PHE A 348
VAL A 492
ALA B1154
PHE B1146
 None
 1.26A 4w5rA-5xogA:
undetectable		 4w5rA-5xogA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 4 PHE A 348
VAL A 492
ALA B1154
PHE B1146
 None
 1.23A 4w5tA-5xogA:
undetectable		 4w5tA-5xogA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 5 LEU B 707
GLU B 742
MET B 699
HIS B 735
 None
 1.35A 4xi3B-5xogB:
undetectable		 4xi3B-5xogB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 5xog RNA POLYMERASE II
SUBUNIT B12.5
RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
RNA POLYMERASE
SUBUNIT ABC10-ALPHA
SPT4/5 COMPLEX
COMPONENT
(Komagataella
phaffii) 		4 / 8 ASP C  46
ASP L  70
ILE W 789
ASP K   5
 None
 0.90A 4xjeA-5xogC:
undetectable		 4xjeA-5xogC:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 4 GLY B 282
VAL B 284
PHE B 325
ILE B 276
 None
 1.05A 4xv2B-5xogB:
undetectable		 4xv2B-5xogB:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 ILE B1212
ALA B1213
ARG B1215
HIS A  92
PHE A1413
 None
 1.37A 4zo1X-5xogB:
undetectable		 4zo1X-5xogB:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 6 ILE B 632
ARG B 594
ILE B 698
GLU B 694
 None
 1.43A 4zzcB-5xogB:
undetectable
4zzcC-5xogB:
undetectable		 4zzcB-5xogB:
13.70
4zzcC-5xogB:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		3 / 3 THR A 536
HIS A 632
LEU A 589
 None
 0.70A 5axdA-5xogA:
undetectable		 5axdA-5xogA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.85A 5b1bP-5xogA:
3.1
5b1bW-5xogA:
undetectable		 5b1bP-5xogA:
9.55
5b1bW-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 5 ARG B 240
GLY B 238
GLU B  52
ARG B 208
 None
 1.05A 5cdqA-5xogB:
undetectable
5cdqB-5xogB:
undetectable
5cdqC-5xogB:
undetectable		 5cdqA-5xogB:
18.56
5cdqB-5xogB:
11.20
5cdqC-5xogB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 5 ARG B 240
GLY B 238
GLU B  52
ARG B 208
 None
 1.16A 5cdqR-5xogB:
undetectable
5cdqS-5xogB:
undetectable
5cdqT-5xogB:
undetectable		 5cdqR-5xogB:
18.56
5cdqS-5xogB:
11.20
5cdqT-5xogB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 5xog RNA POLYMERASE II
SUBUNIT B12.5
RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
RNA POLYMERASE
SUBUNIT ABC10-ALPHA
SPT4/5 COMPLEX
COMPONENT
(Komagataella
phaffii) 		4 / 8 ASP C  46
ASP L  70
ILE W 789
ASP K   5
 None
 0.99A 5cfsA-5xogC:
undetectable		 5cfsA-5xogC:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		4 / 6 TYR C 180
ASP C 181
TYR B1073
PHE C 191
 None
 1.47A 5e2iA-5xogC:
undetectable		 5e2iA-5xogC:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		3 / 3 ARG C 227
THR C 208
TRP C 209
 None
 0.89A 5g6cA-5xogC:
undetectable		 5g6cA-5xogC:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 8 GLN B1093
ILE B 756
GLY B 774
LEU B1095
 None
 1.00A 5hwaA-5xogB:
undetectable		 5hwaA-5xogB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE
SUBUNIT ABC10-ALPHA
(Komagataella
phaffii) 		4 / 8 ILE B 899
ARG L  65
GLY B 902
THR L  63
 None
 1.01A 5hwaA-5xogB:
undetectable		 5hwaA-5xogB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 ALA B1054
ASN B1057
LEU B1058
 None
 0.27A 5i1nB-5xogB:
undetectable		 5i1nB-5xogB:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 ALA B1054
ASN B1057
LEU B1058
 None
 0.40A 5i1oC-5xogB:
undetectable		 5i1oC-5xogB:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 ALA B1054
ASN B1057
LEU B1058
 None
 0.37A 5i1pA-5xogB:
undetectable		 5i1pA-5xogB:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5xog SPT4/5 COMPLEX
COMPONENT
(Komagataella
phaffii) 		4 / 6 PHE W 778
VAL W 770
ILE W 798
ASP W 809
 None
 1.20A 5iwuA-5xogW:
undetectable		 5iwuA-5xogW:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 6 ILE B 910
GLY B 947
ASN B 946
ILE B 911
 None
 1.00A 5j4nB-5xogB:
undetectable		 5j4nB-5xogB:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
TRANSCRIPTION
ELONGATION FACTOR 1
HOMOLOG
(Komagataella
phaffii;
Komagataella
pastoris) 		3 / 3 ASP A 178
ASN M  32
GLN M  22
 None
 0.78A 5k7uA-5xogA:
undetectable		 5k7uA-5xogA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 8 THR A 810
SER A 784
ASP A 792
SER A 794
 None
 1.09A 5l5fY-5xogA:
undetectable
5l5fZ-5xogA:
undetectable		 5l5fY-5xogA:
9.75
5l5fZ-5xogA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		3 / 3 HIS A 787
GLU B 695
TRP B 512
 None
 1.10A 5odqD-5xogA:
undetectable		 5odqD-5xogA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 ARG A 470
PRO A 465
TYR B 833
 None
 1.08A 5tzoB-5xogA:
undetectable		 5tzoB-5xogA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 8 SER B 233
HIS B 356
PHE B 370
MET B 374
 None
 1.24A 5u6nA-5xogB:
undetectable		 5u6nA-5xogB:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 GLN B 474
HIS B 487
ARG B 490
ARG B 497
PRO B 521
 A  P   7 ( 3.9A)
None
G  P   8 ( 4.7A)
A  P   7 ( 4.9A)
G  P   8 ( 4.9A)
 1.02A 5uhbC-5xogB:
22.6		 5uhbC-5xogB:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 7 THR B 484
ARG B 478
ASP B 189
SER B 167
 None
 1.09A 5uxcA-5xogB:
undetectable		 5uxcA-5xogB:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 7 PHE A 815
HIS A 787
PRO A 786
ILE B 700
 None
 0.89A 5vkqA-5xogA:
5.3
5vkqD-5xogA:
3.8		 5vkqA-5xogA:
22.75
5vkqD-5xogA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 7 PHE A 815
HIS A 787
PRO A 786
ILE B 700
 None
 0.91A 5vkqA-5xogA:
5.3
5vkqB-5xogA:
3.8		 5vkqA-5xogA:
22.75
5vkqB-5xogA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 8 PHE A 815
HIS A 787
PRO A 786
ILE B 700
 None
 0.87A 5vkqB-5xogA:
3.8
5vkqC-5xogA:
3.8		 5vkqB-5xogA:
22.75
5vkqC-5xogA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 7 PHE A 815
HIS A 787
PRO A 786
ILE B 700
 None
 0.87A 5vkqC-5xogA:
3.8
5vkqD-5xogA:
3.8		 5vkqC-5xogA:
22.75
5vkqD-5xogA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE
SUBUNIT ABC10-ALPHA
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 8 ARG B 904
GLN L  68
PHE L  69
ASP L  70
 None
 1.32A 5vunA-5xogB:
undetectable		 5vunA-5xogB:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 8 SER A 664
GLN B1065
PHE B1086
ASN A 743
 None
 1.31A 5vunA-5xogA:
undetectable		 5vunA-5xogA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 8 SER A 664
GLN B1065
PHE B1086
ASN A 743
 None
 1.28A 5vunB-5xogA:
undetectable		 5vunB-5xogA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 8 SER A 664
GLN B1065
PHE B1086
ASN A 743
 None
 1.29A 5vuoB-5xogA:
undetectable		 5vuoB-5xogA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 5 ARG A1348
MET A1378
THR A1379
LEU A1384
 None
 1.32A 5w97J-5xogA:
undetectable		 5w97J-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 9 ILE B 910
ASP B 896
LEU B 898
GLY B 897
ALA B 900
 None
 1.35A 5x66C-5xogB:
undetectable		 5x66C-5xogB:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 THR B 493
GLU B 207
HIS B 511
 None
 0.78A 5xioA-5xogB:
undetectable		 5xioA-5xogB:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 THR B 493
GLU B 207
HIS B 511
 None
 0.79A 5xiqB-5xogB:
undetectable		 5xiqB-5xogB:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 THR B 493
GLU B 207
HIS B 511
 None
 0.80A 5xiqD-5xogB:
undetectable		 5xiqD-5xogB:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
SPT4/5 COMPLEX
COMPONENT
(Komagataella
phaffii;
Komagataella
phaffii;
Komagataella
phaffii) 		4 / 5 PHE C  61
ASP B 950
GLU C  60
ASN W 786
 None
 1.40A 5ybbA-5xogC:
undetectable		 5ybbA-5xogC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		3 / 3 LYS A 652
ASN A 649
SER A 556
 None
 1.27A 5yw0A-5xogA:
undetectable		 5yw0A-5xogA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.94A 5z85C-5xogA:
3.1
5z85J-5xogA:
undetectable		 5z85C-5xogA:
9.55
5z85J-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.96A 5zcqP-5xogA:
3.9
5zcqW-5xogA:
undetectable		 5zcqP-5xogA:
9.55
5zcqW-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 TYR B 479
HIS B1097
MET B1098
 None
G  P   9 ( 4.0A)
None
 1.14A 6af6A-5xogB:
undetectable		 6af6A-5xogB:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii;
Komagataella
phaffii) 		4 / 8 SER A 664
GLN B1065
PHE B1086
ASN A 743
 None
 1.32A 6auuB-5xogA:
undetectable		 6auuB-5xogA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11801_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 4 ARG B1220
ARG A1425
GLY A 862
ARG A 858
 None
 1.28A 6az3P-5xogB:
0.0		 6az3P-5xogB:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE II
SUBUNIT B12.5
RNA POLYMERASE
SUBUNIT ABC10-ALPHA
(Komagataella
phaffii) 		3 / 3 ARG K   6
ARG B 852
ARG L  72
 None
 1.03A 6bplA-5xogK:
undetectable
6bplB-5xogK:
undetectable		 6bplA-5xogK:
16.52
6bplB-5xogK:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
SPT4/5 COMPLEX
COMPONENT
(Komagataella
phaffii;
Komagataella
phaffii) 		5 / 9 HIS W 783
LEU C  98
ALA C 159
SER C  95
ASP C  46
 None
 1.28A 6c2mB-5xogW:
undetectable		 6c2mB-5xogW:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 GLN B 474
HIS B 487
ARG B 490
ARG B 497
PRO B 521
 A  P   7 ( 3.9A)
None
G  P   8 ( 4.7A)
A  P   7 ( 4.9A)
G  P   8 ( 4.9A)
 0.83A 6ccvC-5xogB:
22.8		 6ccvC-5xogB:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 ARG B 969
ARG B 967
ASP B 950
 None
 0.81A 6d8pA-5xogB:
undetectable		 6d8pA-5xogB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 VAL A  17
LEU B1216
LEU A1412
LEU A1433
MET A1432
 None
 1.16A 6f6iA-5xogA:
undetectable
6f6iB-5xogA:
undetectable		 6f6iA-5xogA:
4.27
6f6iB-5xogA:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 5 ARG B 105
ALA B 104
TYR B 111
GLN B 102
 None
 1.27A 6f6sA-5xogB:
undetectable
6f6sB-5xogB:
undetectable		 6f6sA-5xogB:
5.73
6f6sB-5xogB:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		3 / 3 HIS B 740
ARG B 598
ILE B 632
 None
 0.66A 6fgdA-5xogB:
undetectable		 6fgdA-5xogB:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		4 / 5 SER C  73
VAL C 129
ASN C 128
PRO C 132
 None
 1.29A 6fi4A-5xogC:
undetectable
6fi4B-5xogC:
undetectable		 6fi4A-5xogC:
21.29
6fi4B-5xogC:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 ASP A 792
ARG A 775
GLN A 692
GLN A 699
 None
 1.42A 6g31G-5xogA:
4.5		 6g31G-5xogA:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
(Komagataella
phaffii) 		4 / 7 VAL A  17
LEU A1412
LEU A1433
MET A1432
 None
 0.72A 6g9bA-5xogA:
undetectable
6g9bB-5xogA:
undetectable		 6g9bA-5xogA:
4.27
6g9bB-5xogA:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 5 GLN B1065
THR B1090
HIS B1025
LEU B1026
 None
 1.35A 6gbnA-5xogB:
undetectable		 6gbnA-5xogB:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		4 / 5 GLN B1065
THR B1090
HIS B1025
LEU B1026
 None
 1.36A 6gbnD-5xogB:
undetectable		 6gbnD-5xogB:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		6 / 12 GLY A 662
LEU A 659
THR A 540
GLY A 575
ASN A 655
ASN B 834
 None
 1.41A 6gngA-5xogA:
undetectable		 6gngA-5xogA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
(Komagataella
phaffii) 		3 / 3 TRP C 170
ILE C  45
ASP C  46
 None
 0.78A 6i0y7-5xogC:
undetectable		 6i0y7-5xogC:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5xog RNA POLYMERASE II
SUBUNIT B12.5
(Komagataella
phaffii) 		3 / 3 ASN K  29
PRO K  83
GLN K  85
 None
 0.89A 6jnhA-5xogK:
undetectable		 6jnhA-5xogK:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5xog RNA POLYMERASE II
SUBUNIT B12.5
(Komagataella
phaffii) 		3 / 3 ASN K  29
PRO K  83
GLN K  85
 None
 0.90A 6jogA-5xogK:
undetectable		 6jogA-5xogK:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Komagataella
phaffii) 		5 / 12 PHE B 370
GLY B 372
LEU B 265
ILE B 274
MET B 245
 None
 1.45A 6md4A-5xogB:
undetectable		 6md4A-5xogB:
5.69