SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xoi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		5 / 9 ILE A 232
VAL A 228
LEU A 300
ILE A 168
ASP A 164
 None
 1.27A 1nb9A-5xoiA:
undetectable		 1nb9A-5xoiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		5 / 9 LEU A 328
LEU A 257
VAL A 295
GLY A 331
SER A 334
 None
 1.28A 1pxxB-5xoiA:
undetectable		 1pxxB-5xoiA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		5 / 10 LEU A 328
LEU A 257
VAL A 295
GLY A 331
SER A 334
 None
 1.27A 1pxxD-5xoiA:
undetectable		 1pxxD-5xoiA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		6 / 11 HIS A 279
ASP A 281
HIS A 339
VAL A 341
ARG A 363
SER A 299
 MN  A 402 ( 3.4A)
MN  A 402 (-2.5A)
MN  A 402 ( 3.4A)
None
SIN  A 401 (-2.8A)
None
 1.49A 1uofA-5xoiA:
6.9		 1uofA-5xoiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		4 / 5 ILE A 237
SER A 334
ARG A 335
LEU A 257
 None
 1.16A 1y0xX-5xoiA:
undetectable		 1y0xX-5xoiA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		4 / 7 ASN A 365
ASP A 281
HIS A 279
HIS A 339
 SIN  A 401 (-3.5A)
MN  A 402 (-2.5A)
MN  A 402 ( 3.4A)
MN  A 402 ( 3.4A)
 1.12A 3t01A-5xoiA:
undetectable		 3t01A-5xoiA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		4 / 8 PHE A 368
PHE A 229
ASN A 365
PHE A 298
 None
None
SIN  A 401 (-3.5A)
None
 1.08A 3t3sE-5xoiA:
undetectable		 3t3sE-5xoiA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		5 / 9 ARG A 363
VAL A 341
LEU A 364
THR A 367
LEU A 366
 SIN  A 401 (-2.8A)
None
None
SIN  A 401 ( 4.4A)
None
 1.32A 4ubsA-5xoiA:
undetectable		 4ubsA-5xoiA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		5 / 12 ALA A 220
PRO A 222
GLY A 178
GLY A 180
LEU A 175
 None
 0.79A 5c0oH-5xoiA:
undetectable		 5c0oH-5xoiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		5 / 12 HIS A 162
ARG A 170
GLN A 173
GLY A 301
LEU A 300
 None
 1.28A 5m54E-5xoiA:
undetectable		 5m54E-5xoiA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		4 / 7 SER A 297
SER A 299
GLY A 325
ARG A 363
 SIN  A 401 ( 4.1A)
None
None
SIN  A 401 (-2.8A)
 1.03A 6btxA-5xoiA:
undetectable		 6btxA-5xoiA:
undetectable