SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xom'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		3 / 3 ALA A 118
VAL A 130
TRP A 235
 None
 0.93A 1c4dA-5xomA:
undetectable
1c4dB-5xomA:
undetectable		 1c4dA-5xomA:
undetectable
1c4dB-5xomA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		3 / 3 TRP A 235
ALA A 118
VAL A 130
 None
 0.89A 1c4dA-5xomA:
undetectable
1c4dB-5xomA:
undetectable		 1c4dA-5xomA:
undetectable
1c4dB-5xomA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		5 / 12 ILE A 410
GLN A 394
SER A 289
ILE A 290
LEU A 351
 None
 1.18A 1dlsA-5xomA:
undetectable		 1dlsA-5xomA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		4 / 7 PHE A 208
ALA A 118
ILE A 180
ILE A 104
 None
 0.97A 1oniD-5xomA:
undetectable
1oniF-5xomA:
undetectable		 1oniD-5xomA:
undetectable
1oniF-5xomA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		4 / 6 ILE A 315
ARG A 171
LEU A  84
ASP A 284
 None
 1.00A 2rlfA-5xomA:
undetectable
2rlfD-5xomA:
undetectable		 2rlfA-5xomA:
25.35
2rlfD-5xomA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		5 / 12 THR A  85
GLU A 304
TRP A  75
LEU A 236
ILE A 306
 None
 1.42A 2ydoA-5xomA:
undetectable		 2ydoA-5xomA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		3 / 3 GLU A 304
HIS A 247
HIS A 301
 None
 0.87A 3co4A-5xomA:
undetectable		 3co4A-5xomA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		4 / 6 ASP A 318
ALA A 298
TYR A 148
ASP A 152
 None
 1.08A 4mdaA-5xomA:
undetectable		 4mdaA-5xomA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		4 / 6 ASP A 318
ALA A 298
TYR A 148
ASP A 152
 None
 1.09A 4mdbA-5xomA:
undetectable		 4mdbA-5xomA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		3 / 3 ARG A  82
ASP A 413
ARG A 171
 None
 0.96A 4mx0A-5xomA:
undetectable		 4mx0A-5xomA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		4 / 8 HIS A 414
ASP A 413
SER A 345
ARG A 344
 None
 1.23A 4uhxA-5xomA:
undetectable		 4uhxA-5xomA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		5 / 12 ALA A 156
ASP A 299
GLY A 150
THR A 146
TYR A 151
 None
 1.35A 5hfjH-5xomA:
undetectable		 5hfjH-5xomA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		5 / 12 ASP A 123
HIS A  70
ALA A  98
SER A 101
LEU A 234
 None
 1.42A 5m54B-5xomA:
undetectable		 5m54B-5xomA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		5 / 12 ASP A 123
HIS A  70
ALA A  98
SER A 101
ARG A 178
 None
 1.25A 5nd2B-5xomA:
undetectable		 5nd2B-5xomA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		5 / 12 ASP A 123
ASP A  73
ALA A  98
SER A 101
ARG A 178
 None
 1.22A 5syeB-5xomA:
undetectable		 5syeB-5xomA:
11.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		4 / 6 LEU A 236
LYS A 244
GLU A 304
LEU A 317
 None
 0.75A 5xooA-5xomA:
58.0		 5xooA-5xomA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE
(Hydra
vulgaris) 		4 / 5 LEU A 236
VAL A 242
GLU A 304
LEU A 317
 None
 0.34A 5xooB-5xomA:
57.9		 5xooB-5xomA:
100.00