SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xon'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5xon PROTEIN THAT FORMS A
COMPLEX WITH SPT4P
RNA POLYMERASE II
SUBUNIT
(Komagataella
phaffii) 		4 / 8 GLY W 669
ARG G 113
VAL G 148
PHE G 109
 None
 1.19A 1gsfA-5xonW:
undetectable		 1gsfA-5xonW:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5xon PROTEIN THAT FORMS A
COMPLEX WITH SPT4P
RNA POLYMERASE II
SUBUNIT
(Komagataella
phaffii) 		4 / 8 GLY W 669
ARG G 113
VAL G 148
PHE G 109
 None
 1.19A 1gsfB-5xonW:
undetectable		 1gsfB-5xonW:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5xon PROTEIN THAT FORMS A
COMPLEX WITH SPT4P
RNA POLYMERASE II
SUBUNIT
(Komagataella
phaffii) 		4 / 8 GLY W 669
ARG G 113
VAL G 148
PHE G 109
 None
 1.19A 1gsfD-5xonW:
undetectable		 1gsfD-5xonW:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 5xon RNA POLYMERASE II
SUBUNIT
(Komagataella
phaffii) 		5 / 11 ASN G 107
VAL G 103
GLY G 161
ILE G 160
PRO G  81
 None
 0.93A 1n49B-5xonG:
undetectable		 1n49B-5xonG:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 5xon RNA POLYMERASE
SUBUNIT ABC10-BETA,
COMMON TO RNA
POLYMERASES I, II,
AND III
(Komagataella
phaffii) 		3 / 3 CYH J  44
ARG J  47
CYH J   7
 ZN  J 101 (-2.3A)
None
ZN  J 101 (-2.4A)
 1.28A 1p9gA-5xonJ:
undetectable		 1p9gA-5xonJ:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 5xon PROTEIN THAT FORMS A
COMPLEX WITH SPT4P
TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Komagataella
phaffii) 		4 / 5 LYS V   9
PHE V  77
LEU V  19
LEU W 310
 None
 1.47A 1skxA-5xonV:
undetectable		 1skxA-5xonV:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 5xon GENERAL
TRANSCRIPTION
ELONGATION FACTOR
TFIIS
(Komagataella
phaffii) 		4 / 7 LEU U 175
LYS U 161
LEU U 204
ALA U 162
 None
 1.16A 1sn0B-5xonU:
undetectable
1sn0D-5xonU:
undetectable		 1sn0B-5xonU:
21.39
1sn0D-5xonU:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 5xon GENERAL
TRANSCRIPTION
ELONGATION FACTOR
TFIIS
(Komagataella
phaffii) 		4 / 7 LYS U 161
LEU U 204
ALA U 162
LEU U 175
 None
 1.14A 1sn0B-5xonU:
undetectable
1sn0D-5xonU:
undetectable		 1sn0B-5xonU:
21.39
1sn0D-5xonU:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 5xon TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Komagataella
phaffii) 		4 / 5 VAL V  58
TYR V  82
VAL V  74
SER V  66
 None
 1.08A 2x45A-5xonV:
undetectable		 2x45A-5xonV:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 5xon TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Komagataella
phaffii) 		4 / 4 VAL V  58
TYR V  82
VAL V  74
SER V  66
 None
 1.07A 2x45B-5xonV:
undetectable		 2x45B-5xonV:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 5xon TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Komagataella
phaffii) 		4 / 5 VAL V  58
TYR V  82
VAL V  74
SER V  66
 None
 1.12A 2x45C-5xonV:
undetectable		 2x45C-5xonV:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 5xon RNA POLYMERASE II
SUBUNIT
(Komagataella
phaffii) 		4 / 6 ARG G 144
PRO G  81
MET G   1
TRP G  79
 None
 1.38A 3aqiB-5xonG:
undetectable		 3aqiB-5xonG:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5xon TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Komagataella
phaffii) 		3 / 3 LEU V  72
VAL V  18
ARG V 108
 None
 0.84A 3b0wB-5xonV:
undetectable		 3b0wB-5xonV:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5xon TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Komagataella
phaffii) 		4 / 7 LEU V  36
LEU V  90
CYH V  49
SER V  51
 None
 0.73A 3lm8B-5xonV:
undetectable
3lm8D-5xonV:
undetectable		 3lm8B-5xonV:
17.76
3lm8D-5xonV:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5xon TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Komagataella
phaffii) 		4 / 8 LEU V  36
LEU V  90
CYH V  49
SER V  51
 None
 0.81A 3lm8A-5xonV:
undetectable
3lm8C-5xonV:
undetectable		 3lm8A-5xonV:
17.76
3lm8C-5xonV:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5xon TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Komagataella
phaffii) 		4 / 8 LEU V  36
LEU V  90
CYH V  49
SER V  51
 None
 0.75A 3lm8B-5xonV:
undetectable
3lm8D-5xonV:
undetectable		 3lm8B-5xonV:
17.76
3lm8D-5xonV:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xon PROTEIN THAT FORMS A
COMPLEX WITH SPT4P
TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Komagataella
phaffii) 		4 / 8 SER W 316
VAL W 318
ARG V  89
VAL W 313
 None
 1.05A 3nlrA-5xonW:
undetectable
3nlrB-5xonW:
undetectable		 3nlrA-5xonW:
20.93
3nlrB-5xonW:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5xon PROTEIN THAT FORMS A
COMPLEX WITH SPT4P
(Komagataella
phaffii) 		4 / 4 LEU W 257
ALA W 281
ILE W 282
LYS W 246
 None
 1.47A 4eixA-5xonW:
undetectable		 4eixA-5xonW:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5xon RNA POLYMERASE II
SUBUNIT
(Komagataella
phaffii) 		4 / 5 THR G 112
GLY G  98
VAL G  94
PRO G  96
 None
 1.05A 4grkA-5xonG:
undetectable		 4grkA-5xonG:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 5xon TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Komagataella
phaffii) 		5 / 9 ALA V  83
ALA V  11
LEU V  19
LEU V  72
VAL V  74
 None
 1.35A 4or0A-5xonV:
undetectable		 4or0A-5xonV:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5xon PROTEIN THAT FORMS A
COMPLEX WITH SPT4P
(Komagataella
phaffii) 		4 / 6 PHE W 778
VAL W 770
ILE W 798
ASP W 809
 None
 1.20A 5iwuA-5xonW:
undetectable		 5iwuA-5xonW:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5xon TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Komagataella
phaffii) 		5 / 12 GLY V  80
GLY V  61
SER V  66
VAL V  58
LEU V  81
 None
 1.08A 5kocB-5xonV:
undetectable		 5kocB-5xonV:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 5xon PROTEIN THAT FORMS A
COMPLEX WITH SPT4P
TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Komagataella
phaffii) 		3 / 3 ARG V  73
PRO W 213
TYR V 104
 None
 1.01A 5tzoB-5xonV:
undetectable		 5tzoB-5xonV:
18.72