SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xox'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A  58
ASP A  68
ILE A  69
ILE A  70
 None
 0.85A 1p7lD-5xoxA:
undetectable		 1p7lD-5xoxA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A  58
ASP A  68
ILE A  69
ILE A  70
 None
 0.85A 1p7lC-5xoxA:
undetectable		 1p7lC-5xoxA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 222
TYR A  79
GLY A 212
LEU A  51
PHE A 105
 None
 1.43A 1pj7A-5xoxA:
2.9		 1pj7A-5xoxA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A  58
ASP A  68
ILE A  69
ILE A  70
 None
 0.85A 1rg9D-5xoxA:
undetectable		 1rg9D-5xoxA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A  58
ASP A  68
ILE A  69
ILE A  70
 None
 0.85A 1rg9C-5xoxA:
undetectable		 1rg9C-5xoxA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  53
TRP A 113
LEU A 122
PHE A  36
 None
 1.48A 1rukH-5xoxA:
undetectable
1rukL-5xoxA:
undetectable		 1rukH-5xoxA:
18.87
1rukL-5xoxA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A   5
ARG A  10
VAL A   9
 None
 1.04A 2r2vC-5xoxA:
undetectable
2r2vD-5xoxA:
undetectable		 2r2vC-5xoxA:
10.14
2r2vD-5xoxA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 133
ASP A  77
ASP A 131
 None
GTP  A 301 (-2.4A)
None
 0.67A 3jayA-5xoxA:
undetectable		 3jayA-5xoxA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 133
ASP A  77
ASP A 131
 None
GTP  A 301 (-2.4A)
None
 0.70A 3jb2A-5xoxA:
undetectable		 3jb2A-5xoxA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 133
ASP A  77
ASP A 131
 None
GTP  A 301 (-2.4A)
None
 0.64A 3jb3A-5xoxA:
undetectable		 3jb3A-5xoxA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 161
ASN A  46
GLU A 205
 None
 0.93A 3kpdB-5xoxA:
undetectable		 3kpdB-5xoxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SDV_A_911A822_0
(ALPHA-BISABOLENE
SYNTHASE)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 4 ASP A  29
ASP A  77
ARG A 150
ASP A 153
 MG  A 303 (-3.0A)
GTP  A 301 (-2.4A)
None
None
 1.50A 3sdvA-5xoxA:
undetectable		 3sdvA-5xoxA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A 107
LEU A 112
LEU A 122
ASN A  60
 None
 1.21A 4n09B-5xoxA:
undetectable		 4n09B-5xoxA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A  34
SER A  76
ASN A 161
 GTP  A 301 (-4.2A)
GTP  A 301 (-3.9A)
None
 0.83A 5cprB-5xoxA:
undetectable		 5cprB-5xoxA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A  58
ASP A  68
ILE A  69
ILE A  70
 None
 0.86A 5t8sA-5xoxA:
undetectable		 5t8sA-5xoxA:
20.10