SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xoz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)
5xoz TRYPSIN PROTEIN
INHIBITOR 2

(Cicer
arietinum)
5 / 9 ILE A 117
LEU A 148
GLY A 149
PHE A 135
TYR A 140
None
1.07A 1i00A-5xozA:
undetectable
1i00A-5xozA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)
5xoz TRYPSIN PROTEIN
INHIBITOR 2

(Cicer
arietinum)
5 / 9 ILE A 117
LEU A 148
GLY A 149
PHE A 135
TYR A 140
None
1.19A 1i00B-5xozA:
undetectable
1i00B-5xozA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)
5xoz TRYPSIN PROTEIN
INHIBITOR 2

(Cicer
arietinum)
4 / 7 PHE A 107
THR A  48
LEU A  58
ASP A 109
None
1.04A 1yrcA-5xozA:
undetectable
1yrcA-5xozA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)
5xoz TRYPSIN PROTEIN
INHIBITOR 2

(Cicer
arietinum)
4 / 7 PHE A 107
THR A  48
LEU A  58
ASP A 109
None
1.02A 1yrdA-5xozA:
undetectable
1yrdA-5xozA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)
5xoz TRYPSIN PROTEIN
INHIBITOR 2

(Cicer
arietinum)
5 / 12 GLY A 133
ILE A 117
GLY A 149
ALA A 115
ILE A 106
None
0.79A 2rkfA-5xozA:
undetectable
2rkfA-5xozA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)
5xoz TRYPSIN PROTEIN
INHIBITOR 2

(Cicer
arietinum)
5 / 10 ILE A 117
LEU A 148
GLY A 149
PHE A 135
TYR A 140
None
1.07A 2tsrC-5xozA:
undetectable
2tsrC-5xozA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)
5xoz TRYPSIN PROTEIN
INHIBITOR 2

(Cicer
arietinum)
5 / 9 ILE A 117
LEU A 148
GLY A 149
PHE A 135
TYR A 140
None
1.16A 2tsrD-5xozA:
undetectable
2tsrD-5xozA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5xoz TRYPSIN PROTEIN
INHIBITOR 2

(Cicer
arietinum)
4 / 7 ILE A 161
LEU A 148
PHE A 135
THR A  56
None
1.13A 2zxwN-5xozA:
undetectable
2zxwW-5xozA:
undetectable
2zxwN-5xozA:
undetectable
2zxwW-5xozA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)
5xoz TRYPSIN PROTEIN
INHIBITOR 2

(Cicer
arietinum)
4 / 8 TYR A  29
ILE A  82
ILE A 137
ILE A  90
None
0.82A 3p4wC-5xozA:
undetectable
3p4wC-5xozA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)
5xoz TRYPSIN PROTEIN
INHIBITOR 2

(Cicer
arietinum)
5 / 10 ILE A 117
LEU A 148
GLY A 149
PHE A 135
TYR A 140
None
1.16A 4eb4D-5xozA:
undetectable
4eb4D-5xozA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)
5xoz TRYPSIN PROTEIN
INHIBITOR 2

(Cicer
arietinum)
4 / 6 PHE A  83
GLY A  85
THR A  86
ASN A 136
None
0.51A 5x24A-5xozA:
undetectable
5x24A-5xozA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)
5xoz TRYPSIN PROTEIN
INHIBITOR 2

(Cicer
arietinum)
5 / 12 ILE A 117
ASN A 174
LEU A 148
GLY A 149
PHE A 135
None
1.23A 6r2eA-5xozA:
undetectable
6r2eA-5xozA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)
5xoz TRYPSIN PROTEIN
INHIBITOR 2

(Cicer
arietinum)
5 / 11 ILE A 117
ASN A 174
LEU A 148
GLY A 149
PHE A 135
None
1.25A 6r2eG-5xozA:
undetectable
6r2eG-5xozA:
undetectable