SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xqh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX8_A_RTLA135_0 (CELLULAR RETINOL-BINDING PROTEIN I, HOLO)	5xqh	PROTEIN ROGDI HOMOLOG (Homo sapiens)	5 / 12	PHE A 261 LEU A 153 ALA A 156 THR A 46 ILE A 124	None	1.18A	1mx8A-5xqhA: undetectable	1mx8A-5xqhA: 17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA3_A_STRA1001_2 (MINERALOCORTICOID RECEPTOR)	5xqh	PROTEIN ROGDI HOMOLOG (Homo sapiens)	4 / 4	LEU A 31 LEU A 267 SER A 264 LEU A 38	None	1.11A	1ya3A-5xqhA: undetectable	1ya3A-5xqhA: 24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUE_C_SUEC1201_2 (NS3 PROTEASE, NS4A PROTEIN)	5xqh	PROTEIN ROGDI HOMOLOG (Homo sapiens)	4 / 5	PHE A 100 ILE A 62 LEU A 63 LYS A 72	None	1.19A	3sueC-5xqhA: undetectable	3sueC-5xqhA: 20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	5xqh	PROTEIN ROGDI HOMOLOG (Homo sapiens)	5 / 11	GLY A 79 LEU A 77 PHE A 45 ALA A 257 ASP A 256	None	1.28A	4wnuC-5xqhA: undetectable	4wnuC-5xqhA: 18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZO1_X_T3X500_1 (THYROID HORMONE RECEPTOR BETA)	5xqh	PROTEIN ROGDI HOMOLOG (Homo sapiens)	5 / 12	ILE A 251 ALA A 116 ARG A 159 LEU A 160 PHE A 61	None	1.44A	4zo1X-5xqhA: undetectable	4zo1X-5xqhA: 22.22

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MX8_A_RTLA135_0","CELLULAR RETINOL-BINDING PROTEIN I, HOLO","5xqh","PROTEIN ROGDI HOMOLOG","Homo sapiens",5,"PHE A 261;LEU A 153;ALA A 156;THR A  46;ILE A 124","None","1.18A","1mx8A-5xqhA:undetectable","1mx8A-5xqhA:17.54"],["1YA3_A_STRA1001_2","MINERALOCORTICOID RECEPTOR","5xqh","PROTEIN ROGDI HOMOLOG","Homo sapiens",4,"LEU A  31;LEU A 267;SER A 264;LEU A  38","None","1.11A","1ya3A-5xqhA:undetectable","1ya3A-5xqhA:24.22"],["3SUE_C_SUEC1201_2","NS3 PROTEASE, NS4A PROTEIN","5xqh","PROTEIN ROGDI HOMOLOG","Homo sapiens",4,"PHE A 100;ILE A  62;LEU A  63;LYS A  72","None","1.19A","3sueC-5xqhA:undetectable","3sueC-5xqhA:20.94"],["4WNU_C_QDNC602_1","CYTOCHROME P450 2D6","5xqh","PROTEIN ROGDI HOMOLOG","Homo sapiens",5,"GLY A  79;LEU A  77;PHE A  45;ALA A 257;ASP A 256","None","1.28A","4wnuC-5xqhA:undetectable","4wnuC-5xqhA:18.87"],["4ZO1_X_T3X500_1","THYROID HORMONE RECEPTOR BETA","5xqh","PROTEIN ROGDI HOMOLOG","Homo sapiens",5,"ILE A 251;ALA A 116;ARG A 159;LEU A 160;PHE A  61","None","1.44A","4zo1X-5xqhA:undetectable","4zo1X-5xqhA:22.22"]]