SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 5xr2 PROTEIN/NUCLEIC ACID
DEGLYCASE HCHA
(Staphylococcus
aureus) 		5 / 9 GLY A 200
SER A 206
LEU A 208
LEU A 180
ASP A 177
 None
None
None
LAC  A 401 ( 4.8A)
LAC  A 401 ( 3.9A)
 1.43A 2j2pB-5xr2A:
undetectable
2j2pC-5xr2A:
undetectable		 2j2pB-5xr2A:
21.04
2j2pC-5xr2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 5xr2 PROTEIN/NUCLEIC ACID
DEGLYCASE HCHA
(Staphylococcus
aureus) 		5 / 10 LEU A 189
ALA A 194
VAL A 250
PRO A 217
VAL A 213
 None
 0.97A 2nnjA-5xr2A:
undetectable		 2nnjA-5xr2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5xr2 PROTEIN/NUCLEIC ACID
DEGLYCASE HCHA
(Staphylococcus
aureus) 		5 / 12 VAL A  98
THR A 123
HIS A  87
LEU A 108
VAL A 106
 None
 1.28A 3sp9B-5xr2A:
undetectable		 3sp9B-5xr2A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 5xr2 PROTEIN/NUCLEIC ACID
DEGLYCASE HCHA
(Staphylococcus
aureus) 		4 / 5 LEU A 238
SER A 219
LEU A 235
ASN A 252
 None
 1.18A 4n09B-5xr2A:
4.7		 4n09B-5xr2A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5xr2 PROTEIN/NUCLEIC ACID
DEGLYCASE HCHA
(Staphylococcus
aureus) 		4 / 5 ASN A  77
ALA A  60
GLY A  76
ASP A 218
 None
 0.89A 4n48A-5xr2A:
2.7		 4n48A-5xr2A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5xr2 PROTEIN/NUCLEIC ACID
DEGLYCASE HCHA
(Staphylococcus
aureus) 		4 / 8 THR A 188
LEU A 265
VAL A 154
SER A 153
 None
 1.13A 4qknA-5xr2A:
undetectable		 4qknA-5xr2A:
20.49