SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xra'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		6 / 7 THR A1012
ASN A1014
THR A1059
TRP A1060
GLY A1094
ASP A1095
 FMN  A 601 ( 3.2A)
FMN  A 601 ( 4.1A)
FMN  A 601 ( 3.8A)
FMN  A 601 ( 4.2A)
FMN  A 601 ( 3.4A)
None
 0.73A 1bu5A-5xraA:
29.5		 1bu5A-5xraA:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 8 THR A1012
ASN A1014
THR A1059
GLY A1094
ASP A1095
 FMN  A 601 ( 3.2A)
FMN  A 601 ( 4.1A)
FMN  A 601 ( 3.8A)
FMN  A 601 ( 3.4A)
None
 0.52A 1bu5B-5xraA:
29.6		 1bu5B-5xraA:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 8 THR A1012
THR A1059
TRP A1060
GLY A1094
ASP A1095
 FMN  A 601 ( 3.2A)
FMN  A 601 ( 3.8A)
FMN  A 601 ( 4.2A)
FMN  A 601 ( 3.4A)
None
 0.71A 1bu5B-5xraA:
29.6		 1bu5B-5xraA:
42.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 6 TRP A 356
GLY A 166
PHE A 170
SER A 167
 None
None
8D3  A 602 ( 4.4A)
None
 1.24A 2a3cA-5xraA:
undetectable		 2a3cA-5xraA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 6 TRP A 356
GLY A 166
PHE A 170
SER A 167
 None
None
8D3  A 602 ( 4.4A)
None
 1.32A 2a3cB-5xraA:
undetectable		 2a3cB-5xraA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 12 ALA A1038
THR A1081
ARG A1036
LEU A1005
LEU A1112
 None
 1.16A 2rctA-5xraA:
undetectable		 2rctA-5xraA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		3 / 3 ASP A1028
ARG A1024
ALA A1027
 None
 0.77A 3mbgC-5xraA:
undetectable		 3mbgC-5xraA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 12 ILE A1022
LEU A1054
GLY A1030
VAL A1033
LEU A1052
 None
 1.01A 3uq6A-5xraA:
5.1		 3uq6A-5xraA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 12 ILE A1022
LEU A1054
GLY A1030
VAL A1033
LEU A1052
 None
 0.96A 3vaqA-5xraA:
3.6		 3vaqA-5xraA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 12 ILE A1022
LEU A1054
GLY A1030
VAL A1033
LEU A1052
 None
 0.96A 3vasA-5xraA:
5.3		 3vasA-5xraA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 9 TRP A 279
LEU A 359
LEU A 360
GLY A 357
VAL A 204
 8D3  A 602 ( 3.5A)
8D3  A 602 ( 4.5A)
None
None
None
 1.29A 4c9kB-5xraA:
undetectable		 4c9kB-5xraA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 7 LEU A 286
THR A 201
ILE A 247
GLY A 281
 None
 0.78A 4eq4A-5xraA:
undetectable		 4eq4A-5xraA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 8 LEU A 286
THR A 201
ILE A 247
GLY A 281
 None
 0.72A 4eq4B-5xraA:
undetectable		 4eq4B-5xraA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 7 LEU A 286
THR A 201
ILE A 247
GLY A 281
 None
 0.73A 4eqlA-5xraA:
undetectable		 4eqlA-5xraA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 7 LEU A 286
THR A 201
ILE A 247
GLY A 281
 None
 0.75A 4eqlB-5xraA:
undetectable		 4eqlB-5xraA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 7 LEU A 286
THR A 201
ILE A 247
GLY A 281
 None
 0.74A 4l39B-5xraA:
undetectable		 4l39B-5xraA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 12 ASP A1136
ALA A1133
THR A1059
GLN A1068
THR A1011
 None
None
FMN  A 601 ( 3.8A)
None
FMN  A 601 ( 4.4A)
 1.22A 5hfjC-5xraA:
undetectable		 5hfjC-5xraA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 6 ARG A1131
ARG A1134
ALA A1133
PRO A1130
 None
 1.32A 5odqA-5xraA:
3.0		 5odqA-5xraA:
22.49