SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xrf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
5 / 9 ASP A 200
SER A 206
VAL A 220
GLY A 223
GLY A 234
None
0.58A 1bcuH-5xrfA:
15.3
1bcuH-5xrfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
6 / 12 HIS A  67
ASP A 200
SER A 206
VAL A 220
GLY A 223
GLY A 234
None
0.67A 1etrH-5xrfA:
29.7
1etrH-5xrfA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
5 / 8 ASP A 200
SER A 206
VAL A 220
GLY A 223
GLY A 234
None
0.70A 1f5lA-5xrfA:
9.9
1f5lA-5xrfA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
5 / 6 ASP A 200
SER A 206
VAL A 220
GLY A 223
GLY A 234
None
0.66A 1tnlA-5xrfA:
13.3
1tnlA-5xrfA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
5 / 10 THR A 201
GLY A 148
GLY A 150
ILE A 199
ALA A 166
None
1.03A 1x7pA-5xrfA:
undetectable
1x7pB-5xrfA:
undetectable
1x7pA-5xrfA:
undetectable
1x7pB-5xrfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
5 / 12 ALA A  40
GLN A  82
PRO A 163
GLY A 150
LEU A 159
None
1.35A 2nv4B-5xrfA:
undetectable
2nv4B-5xrfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
5 / 6 ASP A 200
SER A 206
VAL A 220
GLY A 223
GLY A 234
None
0.63A 2otvA-5xrfA:
13.5
2otvA-5xrfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
6 / 12 ASP A 200
SER A 206
VAL A 220
GLY A 223
GLY A 234
TYR A 236
None
0.65A 2p16A-5xrfA:
11.8
2p16A-5xrfA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
6 / 12 ASP A 200
SER A 206
VAL A 220
GLY A 223
GLY A 234
TYR A 236
None
0.57A 2w26A-5xrfA:
10.9
2w26A-5xrfA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
5 / 11 HIS A  67
ASP A 200
SER A 206
GLY A 223
GLY A 234
None
0.69A 3gy3A-5xrfA:
13.3
3gy3A-5xrfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
4 / 6 SER A 206
VAL A 220
GLY A 223
GLY A 234
None
0.63A 3rxfA-5xrfA:
14.6
3rxfA-5xrfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
4 / 5 ASP A 200
SER A 206
VAL A 220
GLY A 234
None
0.60A 3rxhA-5xrfA:
13.4
3rxhA-5xrfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_C_ACTC207_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
4 / 4 LYS A 120
PRO A 121
LEU A 118
ASN A 119
None
1.50A 3tpxC-5xrfA:
undetectable
3tpxC-5xrfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
4 / 7 ASP A 205
GLY A  54
THR A  55
THR A 201
None
0.86A 4acaC-5xrfA:
undetectable
4acaC-5xrfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
4 / 5 ASN A 169
LEU A 171
SER A 142
LEU A 190
None
1.22A 4n09C-5xrfA:
undetectable
4n09C-5xrfA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
4 / 4 ASN A 169
LEU A 171
SER A 142
LEU A 190
None
1.16A 5kb5A-5xrfA:
undetectable
5kb5A-5xrfA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus)
4 / 7 VAL A 114
ARG A  71
GLU A  97
ARG A 101
None
1.02A 5umwB-5xrfA:
undetectable
5umwE-5xrfA:
undetectable
5umwB-5xrfA:
20.69
5umwE-5xrfA:
20.69