SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xrt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 5xrt -
(-) 		5 / 10 ALA A 113
PHE A  87
GLY A 116
GLU A  89
ARG A 269
 None
 1.42A 1cmcA-5xrtA:
undetectable
1cmcB-5xrtA:
undetectable		 1cmcA-5xrtA:
undetectable
1cmcB-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 5xrt -
(-) 		5 / 10 GLU A  89
ARG A 269
ALA A 113
PHE A  87
GLY A 116
 None
 1.44A 1cmcA-5xrtA:
undetectable
1cmcB-5xrtA:
undetectable		 1cmcA-5xrtA:
undetectable
1cmcB-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 5xrt -
(-) 		4 / 8 GLY A 181
SER A 231
TYR A 195
HIS A 184
 None
 1.02A 1maaD-5xrtA:
undetectable		 1maaD-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5xrt -
(-) 		4 / 7 ILE A 245
PRO A 254
PHE A 125
ASN A 126
 None
None
None
NAG  A 525 (-1.9A)
 0.91A 1oniG-5xrtA:
undetectable
1oniI-5xrtA:
undetectable		 1oniG-5xrtA:
undetectable
1oniI-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5xrt -
(-) 		3 / 3 ASP A 172
ASN A 170
THR A 167
 None
None
NAG  A 515 ( 4.2A)
 0.72A 2pymB-5xrtA:
undetectable		 2pymB-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 5xrt -
(-) 		3 / 3 ASP A 241
ASN A 170
SER A 209
 None
 0.97A 3lslA-5xrtA:
undetectable
3lslD-5xrtA:
undetectable		 3lslA-5xrtA:
undetectable
3lslD-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 5xrt -
(-) 		3 / 3 SER A 209
ASP A 241
ASN A 170
 None
 0.99A 3lslA-5xrtA:
undetectable
3lslD-5xrtA:
undetectable		 3lslA-5xrtA:
undetectable
3lslD-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xrt -
(-) 		4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
 None
 0.93A 4eq4A-5xrtA:
undetectable		 4eq4A-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xrt -
(-) 		4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
 None
 0.93A 4eqlA-5xrtA:
undetectable		 4eqlA-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xrt -
(-) 		4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
 None
 0.94A 4eqlB-5xrtA:
undetectable		 4eqlB-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xrt -
(-) 		4 / 6 LEU A 194
TYR A 195
ILE A 252
GLY A 134
 None
 0.92A 4l39A-5xrtA:
undetectable		 4l39A-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xrt -
(-) 		4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
 None
 0.92A 4l39B-5xrtA:
undetectable		 4l39B-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N6P_A_JMSA713_1
(LACTOTRANSFERRIN)		 5xrt -
(-) 		4 / 4 HIS A  18
ALA A  19
VAL A  20
GLU A  35
 None
 1.31A 4n6pA-5xrtA:
undetectable		 4n6pA-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5xrt -
(-) 		4 / 5 ILE A 217
PRO A 185
TYR A 233
VAL A 213
 None
 0.84A 4s0vA-5xrtA:
undetectable		 4s0vA-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 5xrt -
(-) 		4 / 8 HIS A  75
ASN A  96
ARG A 224
THR A  65
 None
 1.18A 5db5A-5xrtA:
undetectable
5db5B-5xrtA:
undetectable		 5db5A-5xrtA:
undetectable
5db5B-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5xrt -
(-) 		4 / 4 LEU A 118
LEU A  66
SER A 115
ALA A 113
 None
 1.11A 5uunA-5xrtA:
undetectable		 5uunA-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNC_A_QI9A301_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5xrt -
(-) 		5 / 9 VAL A 130
SER A 247
GLY A 200
TYR A 195
GLU A 163
 None
None
None
None
NAG  A 511 (-4.1A)
 0.97A 5zncA-5xrtA:
undetectable		 5zncA-5xrtA:
undetectable