SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xs2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI3_B_PE2B2_1
(THYMIDINE KINASE)		 5xs2 CYCLIN-C
(Homo
sapiens) 		5 / 12 HIS B 154
ILE B  62
GLN B  49
TYR B 184
GLU B  98
 None
 1.46A 1ki3B-5xs2B:
undetectable		 1ki3B-5xs2B:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5xs2 CYCLIN-C
(Homo
sapiens) 		5 / 11 LEU B  40
SER B  77
LEU B  78
LYS B  79
LEU B  32
 None
 1.06A 2ceoA-5xs2B:
undetectable		 2ceoA-5xs2B:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5xs2 CYCLIN-C
(Homo
sapiens) 		3 / 3 PHE B 195
TYR B 192
LEU B 160
 None
 0.74A 3keeB-5xs2B:
undetectable		 3keeB-5xs2B:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 5xs2 CYCLIN-C
(Homo
sapiens) 		5 / 9 TYR B 192
ILE B 230
ILE B 197
VAL B 233
THR B 186
 None
 1.19A 5mvnB-5xs2B:
undetectable		 5mvnB-5xs2B:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5xs2 CYCLIN-C
(Homo
sapiens) 		5 / 10 TYR B 192
ILE B 230
ILE B 197
VAL B 233
THR B 186
 None
 1.18A 5mvnD-5xs2B:
2.4		 5mvnD-5xs2B:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5xs2 CYCLIN-C
(Homo
sapiens) 		5 / 10 TYR B 192
ILE B 230
ILE B 197
VAL B 233
THR B 186
 None
 1.29A 5mzrA-5xs2B:
2.4		 5mzrA-5xs2B:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5xs2 CYCLIN-C
(Homo
sapiens) 		5 / 9 TYR B 192
ILE B 230
ILE B 197
VAL B 233
THR B 186
 None
 1.30A 5mzrD-5xs2B:
2.5		 5mzrD-5xs2B:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5xs2 CYCLIN-C
(Homo
sapiens) 		4 / 5 LEU B 159
VAL B 163
GLU B 169
LEU B 173
 None
 1.07A 5xooB-5xs2B:
undetectable		 5xooB-5xs2B:
15.35