SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xs7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 5xs7 GENOME POLYPROTEIN
(Enterovirus
A) 		4 / 7 PHE B  92
PRO B  83
ALA B  96
PHE B 247
 None
 1.07A 1lqtA-5xs7B:
undetectable		 1lqtA-5xs7B:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 5xs7 GENOME POLYPROTEIN
(Enterovirus
A) 		4 / 7 PHE B  92
PRO B  83
ALA B  96
PHE B 247
 None
 1.07A 1lquA-5xs7B:
undetectable		 1lquA-5xs7B:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5xs7 HEAVY CHAIN OF FAB
1D5
LIGHT CHAIN OF FAB
1D5
(Mus
musculus;
Mus
musculus) 		4 / 7 TYR H 103
TYR L  42
PRO L  50
TYR L 103
 None
 0.71A 2oldA-5xs7H:
12.9
2oldB-5xs7H:
13.0		 2oldA-5xs7H:
20.18
2oldB-5xs7H:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5xs7 HEAVY CHAIN OF FAB
1D5
LIGHT CHAIN OF FAB
1D5
(Mus
musculus;
Mus
musculus) 		4 / 7 TYR L  42
PRO L  50
TYR L 103
TYR H 103
 None
 0.64A 2oldA-5xs7L:
17.4
2oldB-5xs7L:
17.2		 2oldA-5xs7L:
27.18
2oldB-5xs7L:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 5xs7 HEAVY CHAIN OF FAB
1D5
(Mus
musculus) 		5 / 12 THR H 123
GLY H   9
LEU H  19
THR H  99
THR H  45
 None
 1.06A 3eeyC-5xs7H:
undetectable		 3eeyC-5xs7H:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 5xs7 HEAVY CHAIN OF FAB
1D5
(Mus
musculus) 		5 / 12 THR H 123
GLY H   9
LEU H  19
THR H  99
THR H  45
 None
 1.01A 3eeyE-5xs7H:
undetectable		 3eeyE-5xs7H:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 5xs7 HEAVY CHAIN OF FAB
1D5
(Mus
musculus) 		5 / 12 THR H 123
GLY H   9
LEU H  19
THR H  99
THR H  45
 None
 1.02A 3eeyF-5xs7H:
undetectable		 3eeyF-5xs7H:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_2
(GENOME POLYPROTEIN)		 5xs7 HEAVY CHAIN OF FAB
1D5
LIGHT CHAIN OF FAB
1D5
(Mus
musculus) 		4 / 4 GLN L 105
PHE H 115
TYR H 112
VAL L  71
 None
 1.21A 3keeA-5xs7L:
undetectable		 3keeA-5xs7L:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5xs7 LIGHT CHAIN OF FAB
1D5
(Mus
musculus) 		5 / 12 TYR L  42
HIS L 116
GLN L 106
GLN L 105
ALA L  38
 None
 1.04A 3ozwB-5xs7L:
undetectable		 3ozwB-5xs7L:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5xs7 HEAVY CHAIN OF FAB
1D5
LIGHT CHAIN OF FAB
1D5
(Mus
musculus;
Mus
musculus) 		4 / 5 LEU L  52
GLN L 105
HIS L 107
GLY H 114
 None
 1.25A 3pp1A-5xs7L:
undetectable		 3pp1A-5xs7L:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5xs7 HEAVY CHAIN OF FAB
1D5
LIGHT CHAIN OF FAB
1D5
(Mus
musculus;
Mus
musculus) 		3 / 3 ASP L   1
ARG H  75
ARG H  43
 None
 0.82A 4x5iA-5xs7L:
undetectable		 4x5iA-5xs7L:
18.79