SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xsj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Clostridium
beijerinckii) 		3 / 3 ASP X 105
ASP X 118
ASP X 108
 None
 0.78A 1eizA-5xsjX:
5.1		 1eizA-5xsjX:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Clostridium
beijerinckii) 		4 / 6 LEU X 181
THR X 188
ALA X 184
LEU X 207
 None
 1.17A 1etb2-5xsjX:
undetectable		 1etb2-5xsjX:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Clostridium
beijerinckii) 		5 / 9 ALA X 206
ASN X  26
TRP X  29
TYR X  28
GLY X 145
 XYP  X 500 (-3.5A)
XYP  X 500 ( 4.4A)
XYP  X 500 (-4.1A)
XYP  X 500 (-4.0A)
None
 1.12A 1ncwH-5xsjX:
undetectable
1ncwL-5xsjX:
undetectable		 1ncwH-5xsjX:
20.92
1ncwL-5xsjX:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Clostridium
beijerinckii) 		5 / 10 ALA X 206
ASN X  26
TRP X  29
TYR X  28
GLY X 145
 XYP  X 500 (-3.5A)
XYP  X 500 ( 4.4A)
XYP  X 500 (-4.1A)
XYP  X 500 (-4.0A)
None
 1.14A 1ruaH-5xsjX:
undetectable
1ruaL-5xsjX:
undetectable		 1ruaH-5xsjX:
20.92
1ruaL-5xsjX:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Clostridium
beijerinckii) 		5 / 9 ALA X 206
ASN X  26
TRP X  29
TYR X  28
GLY X 145
 XYP  X 500 (-3.5A)
XYP  X 500 ( 4.4A)
XYP  X 500 (-4.1A)
XYP  X 500 (-4.0A)
None
 1.15A 1rulH-5xsjX:
undetectable
1rulL-5xsjX:
undetectable		 1rulH-5xsjX:
20.92
1rulL-5xsjX:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Clostridium
beijerinckii) 		5 / 9 ALA X 206
ASN X  26
TRP X  29
TYR X  28
GLY X 145
 XYP  X 500 (-3.5A)
XYP  X 500 ( 4.4A)
XYP  X 500 (-4.1A)
XYP  X 500 (-4.0A)
None
 1.13A 1rumH-5xsjX:
undetectable
1rumL-5xsjX:
undetectable		 1rumH-5xsjX:
20.92
1rumL-5xsjX:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUP_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Clostridium
beijerinckii) 		5 / 9 ALA X 206
ASN X  26
TRP X  29
TYR X  28
GLY X 145
 XYP  X 500 (-3.5A)
XYP  X 500 ( 4.4A)
XYP  X 500 (-4.1A)
XYP  X 500 (-4.0A)
None
 1.13A 1rupH-5xsjX:
undetectable
1rupL-5xsjX:
undetectable		 1rupH-5xsjX:
20.92
1rupL-5xsjX:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Clostridium
beijerinckii) 		5 / 9 VAL X 149
GLY X 146
SER X 177
LEU X 207
ASP X 208
 None
 1.48A 2j2pB-5xsjX:
undetectable
2j2pC-5xsjX:
undetectable		 2j2pB-5xsjX:
22.74
2j2pC-5xsjX:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Clostridium
beijerinckii) 		5 / 10 CYH X 203
ASP X 208
GLY X 211
ALA X 212
ALA X 215
 None
 1.12A 3ucjA-5xsjX:
3.4		 3ucjA-5xsjX:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Clostridium
beijerinckii) 		5 / 10 CYH X 203
VAL X 143
GLY X 211
ALA X 212
ALA X 215
 None
 1.24A 3ucjA-5xsjX:
3.4		 3ucjA-5xsjX:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Clostridium
beijerinckii) 		5 / 10 CYH X 203
ASP X 208
GLY X 211
ALA X 212
ALA X 215
 None
 1.12A 3ucjB-5xsjX:
3.3		 3ucjB-5xsjX:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Clostridium
beijerinckii) 		5 / 11 ARG X 155
GLY X 146
VAL X 149
SER X 177
ASP X 178
 XYP  X 500 (-3.2A)
None
None
None
None
 1.30A 4d9hA-5xsjX:
3.9		 4d9hA-5xsjX:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Clostridium
beijerinckii) 		4 / 4 ILE X 112
VAL X 261
VAL X 100
ARG X 111
 None
 1.40A 4m6tA-5xsjX:
undetectable		 4m6tA-5xsjX:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Clostridium
beijerinckii) 		5 / 12 VAL X 143
ASP X 208
GLY X 211
ALA X 212
LEU X 192
 None
 0.86A 5xxiA-5xsjX:
undetectable		 5xxiA-5xsjX:
22.59