SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xsq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		4 / 8 LEU A 230
LEU A 282
TYR A 279
SER A 245
 None
 1.25A 1hk2A-5xsqA:
undetectable		 1hk2A-5xsqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		5 / 12 LEU A 297
VAL A 216
ILE A 220
VAL A 302
LEU A 309
 None
 1.13A 1s19A-5xsqA:
undetectable		 1s19A-5xsqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		5 / 10 ILE A   8
THR A  42
ILE A  22
LEU A  32
PHE A  83
 None
 1.11A 1z11C-5xsqA:
undetectable		 1z11C-5xsqA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		5 / 10 ILE A   8
THR A  42
ILE A  22
LEU A  32
PHE A  83
 None
 1.11A 1z11D-5xsqA:
undetectable		 1z11D-5xsqA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		5 / 10 LEU A  43
PHE A 116
LEU A  36
ILE A 169
ALA A  25
 None
 1.02A 2bxeB-5xsqA:
2.4		 2bxeB-5xsqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		5 / 12 LEU A  43
PHE A 116
LEU A  36
ILE A 169
ALA A  25
 None
 1.01A 2bxqA-5xsqA:
2.6		 2bxqA-5xsqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		4 / 6 LEU A  96
TYR A  93
ILE A  87
GLY A  38
 None
 0.93A 2du8A-5xsqA:
undetectable		 2du8A-5xsqA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		3 / 3 TYR A 306
GLU A 242
THR A 236
 None
 1.00A 2y7hB-5xsqA:
undetectable		 2y7hB-5xsqA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		5 / 12 GLY A  29
ILE A  22
LEU A  40
LEU A  96
LEU A 100
 None
 1.26A 3cs8A-5xsqA:
undetectable		 3cs8A-5xsqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		5 / 12 LEU A  35
GLY A  33
TYR A  93
ILE A  87
ALA A  25
 None
 1.01A 3gwwA-5xsqA:
undetectable		 3gwwA-5xsqA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		4 / 4 ILE A  75
PHE A  10
ILE A   8
THR A  12
 None
 1.17A 3ia4A-5xsqA:
undetectable		 3ia4A-5xsqA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		5 / 9 PHE A  10
ILE A   8
GLY A  38
THR A  42
PHE A  83
 None
 1.24A 3t3rB-5xsqA:
undetectable		 3t3rB-5xsqA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		5 / 9 PHE A  10
ILE A   8
GLY A  38
THR A  42
PHE A  83
 None
 1.26A 3t3rC-5xsqA:
undetectable		 3t3rC-5xsqA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		5 / 12 CYH A 120
LEU A 117
LEU A  40
ILE A 166
ILE A  26
 None
 0.93A 3ut5B-5xsqA:
undetectable		 3ut5B-5xsqA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 5xsq NUCLEOPROTEIN
PEPTIDE FROM
POLYMERASE COFACTOR
VP35
(Marburg
marburgvirus) 		5 / 12 LEU A 221
PHE B  25
LEU A 253
LEU A 250
ALA A 260
 None
 1.17A 3vw7A-5xsqA:
undetectable		 3vw7A-5xsqA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		5 / 11 LEU A 124
SER A 201
ILE A  26
ILE A 166
VAL A 142
 None
 1.05A 3w67A-5xsqA:
undetectable		 3w67A-5xsqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		5 / 12 PHE A  83
VAL A  86
ILE A  75
GLU A  46
ILE A 113
 None
 1.28A 4a97B-5xsqA:
undetectable
4a97C-5xsqA:
undetectable		 4a97B-5xsqA:
21.14
4a97C-5xsqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		4 / 8 SER A 201
GLN A 204
VAL A 144
THR A 143
 None
 0.83A 4lnwA-5xsqA:
undetectable		 4lnwA-5xsqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		4 / 6 SER A 201
GLN A 204
VAL A 144
THR A 143
 None
 0.67A 4lnxA-5xsqA:
undetectable		 4lnxA-5xsqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		4 / 6 ARG A 264
LEU A 210
ALA A 260
LEU A 250
 None
 0.92A 4wboC-5xsqA:
undetectable		 4wboC-5xsqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		5 / 9 LEU A  32
LEU A  96
ILE A  18
LEU A  43
PRO A  88
 None
 1.28A 5og9A-5xsqA:
undetectable		 5og9A-5xsqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		4 / 5 ASP A  34
ILE A  22
PHE A  83
TYR A  93
 None
 1.21A 6a93B-5xsqA:
undetectable		 6a93B-5xsqA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 5xsq NUCLEOPROTEIN
(Marburg
marburgvirus) 		5 / 12 ILE A 181
HIS A 182
ASN A 186
TYR A  49
LEU A  65
 None
 1.29A 6chgC-5xsqA:
undetectable		 6chgC-5xsqA:
18.71