SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xsx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		3 / 3 ALA A 646
VAL A 680
TRP A 682
 None
 0.89A 1av2A-5xsxA:
undetectable
1av2B-5xsxA:
undetectable		 1av2A-5xsxA:
undetectable
1av2B-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		3 / 3 TRP A 682
ALA A 646
VAL A 680
 None
 0.85A 1av2C-5xsxA:
undetectable
1av2D-5xsxA:
undetectable		 1av2C-5xsxA:
undetectable
1av2D-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 8 ILE A 434
ASN A 523
ASN A 521
MET A 472
 None
 0.61A 1dzmA-5xsxA:
undetectable		 1dzmA-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		5 / 12 ILE A 609
TYR A 506
TYR A 723
LEU A 716
ILE A 721
 None
GOL  A1005 (-4.8A)
GOL  A1005 ( 4.0A)
None
None
 1.09A 1fmlB-5xsxA:
undetectable		 1fmlB-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		3 / 3 ALA A 646
VAL A 680
TRP A 682
 None
 1.02A 1gmkA-5xsxA:
undetectable
1gmkB-5xsxA:
undetectable		 1gmkA-5xsxA:
undetectable
1gmkB-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 5 TYR A 431
ILE A 471
ARG A 425
GLY A 426
 None
 1.20A 1kifA-5xsxA:
undetectable		 1kifA-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 5 TYR A 431
ILE A 471
ARG A 425
GLY A 426
 None
 1.19A 1kifB-5xsxA:
undetectable		 1kifB-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 5 TYR A 431
ILE A 471
ARG A 425
GLY A 426
 None
 1.20A 1kifC-5xsxA:
undetectable		 1kifC-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 5 TYR A 431
ILE A 471
ARG A 425
GLY A 426
 None
 1.19A 1kifD-5xsxA:
undetectable		 1kifD-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 5 TYR A 431
ILE A 471
ARG A 425
GLY A 426
 None
 1.19A 1kifE-5xsxA:
undetectable		 1kifE-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 5 TYR A 431
ILE A 471
ARG A 425
GLY A 426
 None
 1.19A 1kifF-5xsxA:
undetectable		 1kifF-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 5 TYR A 431
ILE A 471
ARG A 425
GLY A 426
 None
 1.19A 1kifG-5xsxA:
undetectable		 1kifG-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 5 TYR A 431
ILE A 471
ARG A 425
GLY A 426
 None
 1.19A 1kifH-5xsxA:
undetectable		 1kifH-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 7 ASP A 487
GLY A 484
ILE A 483
ILE A 700
 GOL  A1004 (-3.5A)
None
None
None
 0.78A 1n49A-5xsxA:
undetectable		 1n49A-5xsxA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 6 ASP A 487
GLY A 484
ILE A 483
ILE A 700
 GOL  A1004 (-3.5A)
None
None
None
 0.79A 1n49D-5xsxA:
undetectable		 1n49D-5xsxA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		5 / 10 ASP A 487
ILE A 488
GLY A 484
ILE A 483
ALA A 530
 GOL  A1004 (-3.5A)
None
None
None
None
 1.01A 1sh9B-5xsxA:
undetectable		 1sh9B-5xsxA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		5 / 12 TYR A 655
ALA A 514
GLY A 510
LEU A 511
PHE A 507
 CTO  A1001 (-3.8A)
None
None
None
None
 1.20A 1vpoH-5xsxA:
2.5
1vpoL-5xsxA:
2.8		 1vpoH-5xsxA:
19.14
1vpoL-5xsxA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		3 / 3 ALA A 646
VAL A 680
TRP A 682
 None
 0.89A 1w5uA-5xsxA:
undetectable
1w5uB-5xsxA:
undetectable		 1w5uA-5xsxA:
undetectable
1w5uB-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		3 / 3 TRP A 682
ALA A 646
VAL A 680
 None
 0.87A 1w5uA-5xsxA:
undetectable
1w5uB-5xsxA:
undetectable		 1w5uA-5xsxA:
undetectable
1w5uB-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 5 TYR A 431
ILE A 471
ARG A 425
GLY A 426
 None
 1.15A 2du8G-5xsxA:
undetectable		 2du8G-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 5 TYR A 431
ILE A 471
ARG A 425
GLY A 426
 None
 1.14A 2du8J-5xsxA:
undetectable		 2du8J-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 6 LEU A 619
PHE A 518
LEU A 525
PHE A 569
 None
 1.11A 2einP-5xsxA:
undetectable
2einW-5xsxA:
undetectable		 2einP-5xsxA:
undetectable
2einW-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		3 / 3 ALA A 646
VAL A 680
TRP A 682
 None
 0.89A 2izqA-5xsxA:
undetectable
2izqB-5xsxA:
undetectable		 2izqA-5xsxA:
undetectable
2izqB-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		3 / 3 TRP A 682
ALA A 646
VAL A 680
 None
 0.88A 2izqC-5xsxA:
undetectable
2izqD-5xsxA:
undetectable		 2izqC-5xsxA:
undetectable
2izqD-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		5 / 11 ASP A 487
GLY A 484
ILE A 483
VAL A 697
ILE A 700
 GOL  A1004 (-3.5A)
None
None
None
None
 1.06A 2qhcA-5xsxA:
undetectable		 2qhcA-5xsxA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		3 / 3 SER A 326
HIS A 417
ASP A 412
 None
PO4  A1007 (-3.8A)
None
 0.75A 2wa2B-5xsxA:
undetectable		 2wa2B-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		3 / 3 TRP A 682
ALA A 646
VAL A 680
 None
 0.91A 3l8lA-5xsxA:
undetectable
3l8lB-5xsxA:
undetectable		 3l8lA-5xsxA:
undetectable
3l8lB-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		3 / 3 TRP A 682
ALA A 646
VAL A 680
 None
 0.89A 3l8lC-5xsxA:
undetectable
3l8lD-5xsxA:
undetectable		 3l8lC-5xsxA:
undetectable
3l8lD-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		5 / 12 ARG A 499
ASP A 487
GLY A 484
ILE A 483
ILE A 700
 GOL  A1004 (-4.0A)
GOL  A1004 (-3.5A)
None
None
None
 0.92A 4q5mA-5xsxA:
undetectable		 4q5mA-5xsxA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		3 / 3 ASP A 566
HIS A 593
LYS A 598
 GOL  A1003 (-3.3A)
GOL  A1003 ( 4.6A)
None
 0.90A 4qzuD-5xsxA:
undetectable		 4qzuD-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 5 LEU A 619
PHE A 518
LEU A 525
PHE A 569
 None
 1.21A 5iy5P-5xsxA:
undetectable
5iy5W-5xsxA:
undetectable		 5iy5P-5xsxA:
undetectable
5iy5W-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 8 ASN A 521
GLU A 647
PHE A 470
TRP A 645
 None
 0.99A 5oh1C-5xsxA:
undetectable		 5oh1C-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 5 LEU A 619
PHE A 518
LEU A 525
PHE A 569
 None
 1.14A 5xdxC-5xsxA:
undetectable
5xdxJ-5xsxA:
undetectable		 5xdxC-5xsxA:
undetectable
5xdxJ-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 5 LEU A 619
PHE A 518
LEU A 525
PHE A 569
 None
 1.18A 5xdxP-5xsxA:
undetectable
5xdxW-5xsxA:
undetectable		 5xdxP-5xsxA:
undetectable
5xdxW-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		4 / 8 ASN A 699
PRO A 695
ILE A 698
GLU A 649
 None
 1.05A 6hzpA-5xsxA:
undetectable		 6hzpA-5xsxA:
undetectable