SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xsy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 6 ASN A 266
PHE A 263
ALA A 373
GLY A 375
 None
 0.76A 1c8lA-5xsyA:
undetectable		 1c8lA-5xsyA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		3 / 3 MET A1009
LEU A1012
SER A1013
 None
 0.68A 1ee2A-5xsyA:
undetectable		 1ee2A-5xsyA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 6 ASN A 266
PHE A 263
ALA A 373
GLY A 375
 None
 0.71A 1gfzA-5xsyA:
undetectable		 1gfzA-5xsyA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 6 HIS A 176
LEU A 180
PHE A 179
VAL A 167
 None
 1.26A 1ibgH-5xsyA:
undetectable		 1ibgH-5xsyA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 9 THR A 140
GLY A 706
PHE A 707
LEU A 704
SER A 738
 None
 1.18A 1l4nA-5xsyA:
undetectable		 1l4nA-5xsyA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 9 THR A 140
GLY A 706
PHE A 707
LEU A 704
SER A 738
 None
 1.19A 1l5kA-5xsyA:
undetectable		 1l5kA-5xsyA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 11 THR A1211
SER A1210
PHE A1247
PHE A1143
LEU A1133
 None
 1.38A 1q23G-5xsyA:
undetectable		 1q23G-5xsyA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		3 / 3 ASP A 307
GLU A 301
ARG A 335
 None
 0.54A 1wopA-5xsyA:
undetectable		 1wopA-5xsyA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 12 ALA A1108
LEU A1457
LEU A1460
ILE A1461
ILE A1464
 None
 0.98A 1xdkB-5xsyA:
undetectable		 1xdkB-5xsyA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 11 PHE A 785
ASN A1257
ILE A1260
GLY A1261
LEU A 790
 None
 0.94A 1z11A-5xsyA:
undetectable		 1z11A-5xsyA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 11 PHE A 785
ASN A1257
ILE A1260
GLY A1261
LEU A 790
 None
 0.95A 1z11B-5xsyA:
undetectable		 1z11B-5xsyA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 10 PHE A 785
ASN A1257
ILE A1260
GLY A1261
LEU A 790
 None
 1.01A 1z11C-5xsyA:
undetectable		 1z11C-5xsyA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 10 PHE A 785
ASN A1257
ILE A1260
GLY A1261
LEU A 790
 None
 0.96A 1z11D-5xsyA:
undetectable		 1z11D-5xsyA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 11 GLN A 261
MET A 264
GLU A1342
SER A1355
LEU A1354
 None
 1.42A 2c12B-5xsyA:
2.9		 2c12B-5xsyA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 6 VAL A1392
SER A1396
ARG A1426
LEU A1428
 None
 1.11A 2f8dA-5xsyA:
undetectable		 2f8dA-5xsyA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 5xsy VOLTAGE-GATED SODIUM
CHANNEL BETA SUBUNIT
1
(Electrophorus
electricus) 		5 / 12 ASN B 113
LEU B 112
VAL B  84
ASP B  86
GLY B  82
 NAG  B 302 (-1.9A)
None
None
None
None
 1.04A 2f8lA-5xsyB:
undetectable		 2f8lA-5xsyB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 8 ASP A 756
TRP A 730
TYR A 714
HIS A 737
 None
 1.29A 2ha2A-5xsyA:
undetectable		 2ha2A-5xsyA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 8 ASP A 756
TRP A 730
TYR A 714
HIS A 737
 None
 1.27A 2ha2B-5xsyA:
undetectable		 2ha2B-5xsyA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		3 / 3 PHE A1491
PHE A1463
PHE A1459
 None
 0.70A 2od9A-5xsyA:
undetectable		 2od9A-5xsyA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 7 LEU A1498
PHE A1468
PHE A1488
ILE A1501
 None
 0.96A 2opxA-5xsyA:
undetectable		 2opxA-5xsyA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		3 / 3 PHE A1491
PHE A1463
PHE A1459
 None
 0.70A 2qqgA-5xsyA:
undetectable		 2qqgA-5xsyA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 5 ILE A1566
PHE A 785
VAL A1135
PHE A1555
 None
 1.11A 2ygnA-5xsyA:
undetectable		 2ygnA-5xsyA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 5xsy SODIUM CHANNEL
PROTEIN
VOLTAGE-GATED SODIUM
CHANNEL BETA SUBUNIT
1
(Electrophorus
electricus;
Electrophorus
electricus) 		4 / 7 TYR B 185
ARG B 186
ILE A 985
ASN A 988
 None
 0.95A 2zseA-5xsyB:
undetectable		 2zseA-5xsyB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 11 THR A 580
ILE A 577
LYS A 666
LEU A 667
THR A 573
 None
 1.42A 3bexC-5xsyA:
undetectable
3bexD-5xsyA:
undetectable		 3bexC-5xsyA:
9.52
3bexD-5xsyA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 10 LYS A 666
LEU A 667
THR A 573
THR A 580
ILE A 577
 None
 1.43A 3bexC-5xsyA:
undetectable
3bexD-5xsyA:
undetectable		 3bexC-5xsyA:
9.52
3bexD-5xsyA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 10 THR A 580
ILE A 577
LYS A 666
LEU A 667
THR A 573
 None
 1.41A 3bexE-5xsyA:
undetectable
3bexF-5xsyA:
undetectable		 3bexE-5xsyA:
9.52
3bexF-5xsyA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 11 THR A 580
ILE A 577
LYS A 666
LEU A 667
THR A 573
 None
 1.42A 3bf1C-5xsyA:
undetectable
3bf1D-5xsyA:
undetectable		 3bf1C-5xsyA:
9.52
3bf1D-5xsyA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 11 THR A 580
ILE A 577
LYS A 666
LEU A 667
THR A 573
 None
 1.40A 3bf1E-5xsyA:
undetectable
3bf1F-5xsyA:
undetectable		 3bf1E-5xsyA:
9.52
3bf1F-5xsyA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 6 ASN A 266
PHE A 263
ALA A 373
GLY A 375
 None
 0.76A 3dd1B-5xsyA:
undetectable		 3dd1B-5xsyA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 6 ASN A 266
PHE A 263
ALA A 373
GLY A 375
 None
 0.76A 3ddsB-5xsyA:
undetectable		 3ddsB-5xsyA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 6 ASN A 266
PHE A 263
ALA A 373
GLY A 375
 None
 0.77A 3ddwB-5xsyA:
undetectable		 3ddwB-5xsyA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 5xsy VOLTAGE-GATED SODIUM
CHANNEL BETA SUBUNIT
1
(Electrophorus
electricus) 		3 / 3 GLU B 180
VAL B 182
CYH B 184
 None
 1.05A 3fbxA-5xsyB:
undetectable		 3fbxA-5xsyB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 5xsy SODIUM CHANNEL
PROTEIN
VOLTAGE-GATED SODIUM
CHANNEL BETA SUBUNIT
1
(Electrophorus
electricus) 		4 / 8 GLU A1527
TYR B 110
ARG A1534
ASP A1532
 None
 1.19A 3mjrD-5xsyA:
undetectable		 3mjrD-5xsyA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 7 ILE A1563
LEU A1567
ILE A1264
ASN A1268
 None
 0.87A 3p50B-5xsyA:
3.0		 3p50B-5xsyA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 7 ILE A1563
LEU A1567
ILE A1264
ASN A1268
 None
 0.87A 3p50C-5xsyA:
3.0		 3p50C-5xsyA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 7 ILE A1563
LEU A1567
ILE A1264
ASN A1268
 None
 0.87A 3p50D-5xsyA:
3.1		 3p50D-5xsyA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 7 ILE A1563
LEU A1567
ILE A1264
ASN A1268
 None
 0.88A 3p50E-5xsyA:
3.0		 3p50E-5xsyA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 11 VAL A1194
TYR A1196
TRP A1507
VAL A1209
GLY A1214
 None
 1.26A 3pghB-5xsyA:
undetectable		 3pghB-5xsyA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 9 LEU A1510
ILE A1496
PHE A1488
MET A1470
GLY A1469
 None
 1.42A 3sj4X-5xsyA:
undetectable		 3sj4X-5xsyA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 11 PHE A 785
ASN A1257
ILE A1260
GLY A1261
LEU A 790
 None
 1.05A 3t3rA-5xsyA:
undetectable		 3t3rA-5xsyA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 8 ASN A 125
ILE A 223
ASN A 185
ASP A 188
 None
 1.11A 4d33A-5xsyA:
undetectable		 4d33A-5xsyA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 7 ASN A 125
ILE A 223
ASN A 185
ASP A 188
 None
 1.11A 4d33B-5xsyA:
undetectable		 4d33B-5xsyA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 8 ASN A 125
ILE A 223
ASN A 185
ASP A 188
 None
 1.08A 4d39A-5xsyA:
0.7		 4d39A-5xsyA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 7 ASN A 125
ILE A 223
ASN A 185
ASP A 188
 None
 1.11A 4d39B-5xsyA:
undetectable		 4d39B-5xsyA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 11 ALA A 668
ILE A 678
ILE A 680
LEU A1258
ILE A 676
 None
 1.07A 4dt8A-5xsyA:
undetectable		 4dt8A-5xsyA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 10 ALA A 668
ILE A 678
ILE A 680
LEU A1258
ILE A 676
 None
 1.06A 4dt8B-5xsyA:
undetectable		 4dt8B-5xsyA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 10 ALA A 668
ILE A 678
ILE A 680
LEU A1258
ILE A 676
 None
 1.02A 4dtaA-5xsyA:
undetectable		 4dtaA-5xsyA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		6 / 12 ALA A 411
GLU A 407
THR A 229
ILE A 230
LEU A 691
THR A 412
 None
 1.29A 4ej1B-5xsyA:
undetectable		 4ej1B-5xsyA:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		3 / 3 PHE A1244
TYR A1220
TYR A1241
 None
 1.02A 4ffwA-5xsyA:
undetectable		 4ffwA-5xsyA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 6 ILE A1260
ILE A 394
PHE A 785
LEU A 786
 None
 0.98A 4m51A-5xsyA:
undetectable		 4m51A-5xsyA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 5 ASN A1198
SER A 584
LEU A 598
ASN A 602
 None
 1.28A 4n09C-5xsyA:
undetectable		 4n09C-5xsyA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 6 LEU A1011
MET A1115
LEU A1460
ILE A1467
 None
 1.11A 4okxA-5xsyA:
undetectable		 4okxA-5xsyA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 6 GLU A 162
TYR A 159
ILE A 132
THR A 131
 None
 1.20A 4qwpA-5xsyA:
undetectable		 4qwpA-5xsyA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 12 TRP A1507
GLY A1506
GLY A1480
LEU A1512
PRO A1513
 None
 1.27A 4uinH-5xsyA:
undetectable
4uinL-5xsyA:
undetectable		 4uinH-5xsyA:
8.19
4uinL-5xsyA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 5xsy VOLTAGE-GATED SODIUM
CHANNEL BETA SUBUNIT
1
(Electrophorus
electricus) 		4 / 6 ARG B  92
ARG B  88
VAL B 114
ASP B 118
 None
 1.34A 4xqeA-5xsyB:
undetectable		 4xqeA-5xsyB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5xsy VOLTAGE-GATED SODIUM
CHANNEL BETA SUBUNIT
1
(Electrophorus
electricus) 		4 / 6 ARG B  92
ARG B  88
VAL B 114
ASP B 118
 None
 1.32A 4xqeB-5xsyB:
undetectable		 4xqeB-5xsyB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 5xsy VOLTAGE-GATED SODIUM
CHANNEL BETA SUBUNIT
1
(Electrophorus
electricus) 		5 / 11 GLY B  51
ASP B 103
ARG B 128
GLU B  52
THR B 101
 None
 1.48A 4xt7A-5xsyB:
undetectable		 4xt7A-5xsyB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 11 GLY A 242
ILE A 775
LEU A 779
LEU A 782
MET A 403
 None
 1.06A 4xumB-5xsyA:
undetectable		 4xumB-5xsyA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 6 TYR A1243
GLY A1202
SER A1205
LEU A1206
 None
 1.26A 5bphA-5xsyA:
undetectable		 5bphA-5xsyA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 4 TYR A1243
GLY A1202
SER A1205
LEU A1206
 None
 1.25A 5bphC-5xsyA:
undetectable		 5bphC-5xsyA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		3 / 3 THR A 992
THR A 995
PHE A1002
 None
 0.91A 5cxvA-5xsyA:
undetectable		 5cxvA-5xsyA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 12 LEU A1069
ASP A1038
LEU A1017
ILE A1461
VAL A1074
 None
 1.37A 5dlvB-5xsyA:
undetectable		 5dlvB-5xsyA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 4 LEU A1011
ILE A1010
PRO A1105
LEU A1460
 None
 1.21A 5eb3A-5xsyA:
undetectable		 5eb3A-5xsyA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 12 GLY A1543
PHE A1247
ILE A1248
GLY A1251
THR A1545
 None
 0.96A 5eqbA-5xsyA:
0.7		 5eqbA-5xsyA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 5 ILE A 397
LEU A 388
GLY A 389
PHE A 391
 None
 0.94A 5kmdC-5xsyA:
12.8
5kmdD-5xsyA:
11.9		 5kmdC-5xsyA:
10.02
5kmdD-5xsyA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		5 / 12 ALA A1108
LEU A1457
LEU A1460
ILE A1461
ILE A1464
 None
 1.01A 5uanB-5xsyA:
undetectable		 5uanB-5xsyA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 5 PHE A 785
PHE A1254
LEU A 788
LEU A 746
 None
 1.22A 5veuH-5xsyA:
0.6		 5veuH-5xsyA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		3 / 3 ARG A1026
LYS A 323
ARG A1027
 None
 1.41A 6az3C-5xsyA:
2.1
6az3L-5xsyA:
undetectable
6az3M-5xsyA:
undetectable		 6az3C-5xsyA:
3.92
6az3L-5xsyA:
3.49
6az3M-5xsyA:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5xsy SODIUM CHANNEL
PROTEIN
(Electrophorus
electricus) 		4 / 5 LEU A 727
ILE A 751
MET A 732
GLY A 711
 None
 1.03A 6hd6A-5xsyA:
2.9		 6hd6A-5xsyA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5xsy VOLTAGE-GATED SODIUM
CHANNEL BETA SUBUNIT
1
(Electrophorus
electricus) 		4 / 7 GLY B 120
THR B 121
PHE B  63
SER B  69
 None
 0.90A 6jnhA-5xsyB:
undetectable		 6jnhA-5xsyB:
20.38