SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xsz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 5xsz LYSOPHOSPHATIDIC
ACID RECEPTOR
6A,ENDOLYSIN,LYSOPHO
SPHATIDIC ACID
RECEPTOR 6A
(Danio
rerio;
Escherichia
virus
T4) 		5 / 12 LEU A1015
ALA A1063
GLY A1030
LEU A1046
PHE A 132
 None
 1.40A 1brpA-5xszA:
undetectable		 1brpA-5xszA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5xsz LYSOPHOSPHATIDIC
ACID RECEPTOR
6A,ENDOLYSIN,LYSOPHO
SPHATIDIC ACID
RECEPTOR 6A
(Danio
rerio;
Escherichia
virus
T4) 		4 / 5 SER A 306
PHE A  52
VAL A 301
PHE A 304
 None
 1.40A 1oipA-5xszA:
undetectable		 1oipA-5xszA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5xsz LYSOPHOSPHATIDIC
ACID RECEPTOR
6A,ENDOLYSIN,LYSOPHO
SPHATIDIC ACID
RECEPTOR 6A
(Danio
rerio;
Escherichia
virus
T4) 		5 / 10 GLY A  41
VAL A  37
THR A  44
ASN A  45
VAL A  77
 None
 0.99A 1pwyE-5xszA:
undetectable		 1pwyE-5xszA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xsz LYSOPHOSPHATIDIC
ACID RECEPTOR
6A,ENDOLYSIN,LYSOPHO
SPHATIDIC ACID
RECEPTOR 6A
(Danio
rerio;
Escherichia
virus
T4) 		5 / 12 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
 None
 0.99A 2aclA-5xszA:
undetectable
2aclE-5xszA:
undetectable		 2aclA-5xszA:
19.67
2aclE-5xszA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 5xsz LYSOPHOSPHATIDIC
ACID RECEPTOR
6A,ENDOLYSIN,LYSOPHO
SPHATIDIC ACID
RECEPTOR 6A
(Danio
rerio;
Escherichia
virus
T4) 		4 / 8 ASN A 259
GLU A 199
VAL A 280
TYR A 284
 None
 1.15A 2fl5E-5xszA:
undetectable
2fl5F-5xszA:
undetectable		 2fl5E-5xszA:
17.26
2fl5F-5xszA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 5xsz LYSOPHOSPHATIDIC
ACID RECEPTOR
6A,ENDOLYSIN,LYSOPHO
SPHATIDIC ACID
RECEPTOR 6A
(Danio
rerio;
Escherichia
virus
T4) 		3 / 3 SER A 113
ASP A 298
ASN A  45
 None
 0.99A 3lsfB-5xszA:
undetectable
3lsfE-5xszA:
undetectable		 3lsfB-5xszA:
18.07
3lsfE-5xszA:
18.07