SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xt3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		5 / 12 VAL A 415
ILE A 324
LEU A 472
ILE A 440
THR A 413
 None
 1.18A 1d1gB-5xt3A:
undetectable		 1d1gB-5xt3A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		4 / 6 VAL A 469
VAL A 438
ILE A 324
ARG A 359
 None
 1.11A 1iepA-5xt3A:
undetectable		 1iepA-5xt3A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		4 / 7 LEU A 372
ALA A 350
GLY A 352
PHE A 398
 None
 0.94A 2wq5A-5xt3A:
undetectable		 2wq5A-5xt3A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		4 / 7 GLY A 356
ALA A 361
VAL A 338
ILE A 370
 None
 0.66A 3a2qA-5xt3A:
undetectable		 3a2qA-5xt3A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		4 / 5 HIS A 443
ASP A 418
HIS A 442
ASP A 349
 None
MN  A 701 ( 2.5A)
MN  A 701 (-3.9A)
MN  A 701 (-3.2A)
 1.24A 3c0zA-5xt3A:
undetectable		 3c0zA-5xt3A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		4 / 5 ARG A 504
ASP A 418
ASP A 349
ASP A 347
 None
MN  A 701 ( 2.5A)
MN  A 701 (-3.2A)
MN  A 702 (-2.9A)
 1.35A 3naiC-5xt3A:
undetectable		 3naiC-5xt3A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		4 / 5 PRO A 346
ASP A 376
ILE A 370
VAL A 430
 None
 1.41A 4hytA-5xt3A:
2.6		 4hytA-5xt3A:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		4 / 8 GLY A 352
MET A 385
PHE A 398
ILE A 370
 None
 0.95A 4j4vC-5xt3A:
undetectable		 4j4vC-5xt3A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		5 / 12 GLU A 334
LEU A 454
ASN A 452
ASN A 435
LYS A 411
 None
 1.35A 5kc4A-5xt3A:
undetectable		 5kc4A-5xt3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		5 / 10 LEU A 394
ILE A 351
ALA A 354
ILE A 355
ILE A 340
 None
 0.97A 5mvmD-5xt3A:
undetectable
5mvmE-5xt3A:
undetectable		 5mvmD-5xt3A:
18.68
5mvmE-5xt3A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		4 / 6 ASP A 441
HIS A 442
HIS A 443
HIS A 343
 None
MN  A 701 (-3.9A)
None
MN  A 702 (-3.6A)
 0.94A 5ncdA-5xt3A:
undetectable
5ncdD-5xt3A:
undetectable		 5ncdA-5xt3A:
undetectable
5ncdD-5xt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		4 / 6 HIS A 343
ASP A 441
HIS A 442
HIS A 443
 MN  A 702 (-3.6A)
None
MN  A 701 (-3.9A)
None
 0.92A 5ncdB-5xt3A:
undetectable
5ncdC-5xt3A:
undetectable		 5ncdB-5xt3A:
undetectable
5ncdC-5xt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		4 / 6 ASP A 441
HIS A 442
HIS A 443
HIS A 343
 None
MN  A 701 (-3.9A)
None
MN  A 702 (-3.6A)
 0.89A 5nelA-5xt3A:
undetectable
5nelD-5xt3A:
undetectable		 5nelA-5xt3A:
undetectable
5nelD-5xt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		5 / 12 VAL A 417
ASP A 418
LEU A 394
PRO A 346
LEU A 381
 None
MN  A 701 ( 2.5A)
None
None
None
 1.10A 5syfB-5xt3A:
undetectable		 5syfB-5xt3A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		4 / 8 GLU A 474
ARG A 508
THR A 509
ILE A 494
 None
 1.12A 6a4iA-5xt3A:
undetectable		 6a4iA-5xt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		5 / 12 THR A 623
VAL A 609
TYR A 587
THR A 612
LEU A 649
 None
 1.24A 6ak3A-5xt3A:
undetectable		 6ak3A-5xt3A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		3 / 3 ARG A 499
ARG A 602
ASP A 575
 None
C2E  A 703 (-3.0A)
C2E  A 703 (-3.5A)
 0.86A 6d8pA-5xt3A:
undetectable		 6d8pA-5xt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		5 / 12 LEU A 394
ILE A 351
THR A 465
VAL A 469
LEU A 525
 None
 0.95A 6djzA-5xt3A:
undetectable		 6djzA-5xt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES
(Staphylococcus
aureus) 		5 / 12 LEU A 394
ILE A 351
THR A 465
VAL A 469
LEU A 525
 None
 1.18A 6djzB-5xt3A:
undetectable		 6djzB-5xt3A:
undetectable