SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xtb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xtb NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 2,
MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
4, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR L 174
LEU O  83
VAL O  82
VAL O 112
VAL O  67
 None
 1.22A 1q23H-5xtbL:
undetectable
1q23I-5xtbL:
undetectable		 1q23H-5xtbL:
21.11
1q23I-5xtbL:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU M 357
LEU M 354
LEU M 351
ALA M 350
LEU M 584
 None
 1.15A 1ya3C-5xtbM:
undetectable		 1ya3C-5xtbM:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE M 222
MET M 213
PHE M 214
ILE M 691
THR M 171
 None
 1.12A 2blaA-5xtbM:
undetectable		 2blaA-5xtbM:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE M 622
LEU M 330
ILE M 567
LEU M 547
ILE M 623
 None
 1.05A 2cd2A-5xtbM:
undetectable		 2cd2A-5xtbM:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLN M 522
ILE M 537
ALA M 340
ALA M 339
VAL M 338
 None
 1.00A 2oc8A-5xtbM:
undetectable		 2oc8A-5xtbM:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5xtb NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
4, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG L 106
THR L 103
THR M 606
ASP M 347
 None
 1.28A 2okcB-5xtbL:
undetectable		 2okcB-5xtbL:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG M 382
SER M 650
TYR M 385
 None
 0.91A 2q2hA-5xtbM:
undetectable
2q2hB-5xtbM:
undetectable		 2q2hA-5xtbM:
11.69
2q2hB-5xtbM:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5xtb NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 2,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP O 206
THR O 164
PRO O 165
 None
 0.63A 2q64B-5xtbO:
undetectable		 2q64B-5xtbO:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TYR M 589
GLU M 591
THR M 265
 None
 0.89A 2y7hB-5xtbM:
undetectable		 2y7hB-5xtbM:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
6, MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		4 / 5 ILE M 223
PRO M 235
VAL T  99
PHE M 238
 None
 1.29A 2ygnA-5xtbM:
undetectable		 2ygnA-5xtbM:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE M 418
ILE M 391
VAL M 475
PRO M 407
LEU M 516
 None
 1.11A 3a51A-5xtbM:
undetectable		 3a51A-5xtbM:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE M 418
ILE M 391
VAL M 475
PRO M 407
LEU M 516
 None
 1.12A 3a51C-5xtbM:
undetectable		 3a51C-5xtbM:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE M 418
ILE M 391
VAL M 475
PRO M 407
LEU M 516
 None
 1.10A 3a51D-5xtbM:
undetectable		 3a51D-5xtbM:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE M 418
ILE M 391
VAL M 475
PRO M 407
LEU M 516
 None
 1.07A 3a51E-5xtbM:
undetectable		 3a51E-5xtbM:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA M 322
ILE M 583
ILE M 629
GLU M 628
ALA M 625
 None
 1.10A 3axtA-5xtbM:
undetectable		 3axtA-5xtbM:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE M 583
ILE M 629
SER M 324
GLU M 628
ALA M 625
 None
 1.09A 3axtA-5xtbM:
undetectable		 3axtA-5xtbM:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5xtb NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 VAL O 107
ILE O  95
LEU O  83
VAL O 115
VAL O  79
 None
 1.05A 3gwxA-5xtbO:
undetectable		 3gwxA-5xtbO:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA M 520
SER M 701
ILE M 700
ARG M 301
LEU M 297
 None
 1.42A 3ia4A-5xtbM:
undetectable		 3ia4A-5xtbM:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE M 261
SER M 701
ILE M 700
ARG M 301
LEU M 297
 None
 1.17A 3ia4B-5xtbM:
undetectable		 3ia4B-5xtbM:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 5xtb NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
4, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP L 119
SER L 122
ARG L 106
 None
 0.74A 3loqA-5xtbL:
undetectable		 3loqA-5xtbL:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE M 515
ASN M 384
PRO M 373
LEU M 481
 None
 1.08A 3oi8A-5xtbM:
undetectable		 3oi8A-5xtbM:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU M 218
GLY M 220
PHE M 185
ALA M 186
ALA M 190
 None
 1.07A 3sufA-5xtbM:
undetectable		 3sufA-5xtbM:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 PHE M 238
LYS M 170
SER M 233
 None
 1.25A 3tyeB-5xtbM:
undetectable		 3tyeB-5xtbM:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ALA M 580
LEU M 545
GLY M 586
HIS M 571
LEU M 302
 None
 1.29A 3uudA-5xtbM:
undetectable		 3uudA-5xtbM:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5xtb NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
4, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASN L 167
TRP L 166
ASP M 426
 None
 0.88A 4a7tA-5xtbL:
undetectable
4a7tF-5xtbL:
undetectable		 4a7tA-5xtbL:
21.38
4a7tF-5xtbL:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5xtb NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 2,
MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 THR M 208
GLY M 196
ASP M 193
ARG M 408
MET O 110
 None
 1.29A 4dx7A-5xtbM:
0.0		 4dx7A-5xtbM:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE M 222
GLY M 220
ILE M 691
LEU M 195
 None
 0.62A 4o8fB-5xtbM:
undetectable		 4o8fB-5xtbM:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLN M 453
LEU M 452
SER M 448
ASP M 485
 None
 1.31A 4qtuD-5xtbM:
undetectable		 4qtuD-5xtbM:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 5xtb NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
6, MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ALA T  73
VAL T  77
GLY T 110
THR T 111
 None
 1.14A 4ubeA-5xtbT:
undetectable		 4ubeA-5xtbT:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 5xtb NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
4, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		3 / 3 VAL M  71
TYR L 160
ALA M  93
 None
 0.56A 4ybnA-5xtbM:
undetectable		 4ybnA-5xtbM:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 LEU M 401
LEU M 452
ILE M 455
SER M 495
ALA M 497
 None
 1.28A 4z69A-5xtbM:
undetectable		 4z69A-5xtbM:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 5xtb NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLU O 194
ASP O 195
VAL O 181
ALA O 179
 None
 1.37A 5dl9A-5xtbO:
undetectable		 5dl9A-5xtbO:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY M 376
ILE M 451
GLY M 433
GLY M 404
THR M 374
 None
 0.95A 5eqbA-5xtbM:
undetectable		 5eqbA-5xtbM:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLU M 118
GLY M 115
ASN M  74
CYH M 179
CYH M  64
 None
None
None
SF4  M 802 (-2.7A)
FES  M 803 (-3.2A)
 1.34A 5fhzD-5xtbM:
undetectable		 5fhzD-5xtbM:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 TYR M 656
THR M 606
THR M 595
SER M 259
GLY M 258
 None
 1.01A 5lf7V-5xtbM:
undetectable
5lf7b-5xtbM:
undetectable		 5lf7V-5xtbM:
18.57
5lf7b-5xtbM:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 TYR M 656
THR M 606
THR M 595
SER M 259
GLY M 258
 None
 1.03A 5lf7H-5xtbM:
undetectable
5lf7N-5xtbM:
undetectable		 5lf7H-5xtbM:
18.57
5lf7N-5xtbM:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU M 452
ASP M 447
ALA M 480
GLN M 677
PRO M 373
 None
 1.41A 5syfB-5xtbM:
undetectable		 5syfB-5xtbM:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 5xtb NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
12
NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG M 308
PRO M 578
TYR N 144
 None
 0.89A 5tzoB-5xtbM:
undetectable		 5tzoB-5xtbM:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE M 455
ALA M 492
LEU M 476
ILE M 451
 None
 0.76A 5uihA-5xtbM:
undetectable		 5uihA-5xtbM:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5xtb NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
6, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLN T 118
THR T 109
GLU T  79
SER T  78
 None
 1.06A 6fbvC-5xtbT:
undetectable		 6fbvC-5xtbT:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 VAL M 436
ASN M 406
PRO M 407
GLU M 217
 None
 1.14A 6h7uA-5xtbM:
undetectable		 6h7uA-5xtbM:
22.65