SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xtc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT 3
(Homo
sapiens;
Homo
sapiens) 		3 / 3 TRP Y  71
ALA Z  77
VAL Z  82
 None
 0.81A 1bdwA-5xtcY:
undetectable
1bdwB-5xtcY:
undetectable		 1bdwA-5xtcY:
33.33
1bdwB-5xtcY:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
5
(Homo
sapiens) 		4 / 8 LEU h   4
ARG h  16
PHE h  10
GLY h  11
 None
 0.86A 1fapB-5xtch:
undetectable		 1fapB-5xtch:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		4 / 8 VAL i 118
LEU i 130
PRO i 116
SER i 183
 None
 1.14A 1jtvA-5xtci:
undetectable		 1jtvA-5xtci:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
13
(Homo
sapiens) 		3 / 3 GLU W  94
LYS W 105
VAL W 106
 None
 0.90A 1l2iA-5xtcW:
undetectable		 1l2iA-5xtcW:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
10
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
11, MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ILE d  96
TYR d  10
ILE d  99
ALA e 122
GLU e 123
 None
 1.38A 1mrgA-5xtcd:
undetectable		 1mrgA-5xtcd:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA888_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
5
(Homo
sapiens;
Homo
sapiens) 		4 / 5 PRO h  26
LYS h  28
MET h  29
ALA a 185
 None
 1.46A 1qhsA-5xtch:
undetectable		 1qhsA-5xtch:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
5
(Homo
sapiens;
Homo
sapiens) 		4 / 6 PRO h  26
LYS h  28
MET h  29
ALA a 185
 None
 1.48A 1qhyA-5xtch:
undetectable		 1qhyA-5xtch:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
13
(Homo
sapiens) 		3 / 3 TRP W 116
VAL W 117
PRO W 118
 None
 0.69A 1rg1A-5xtcW:
undetectable		 1rg1A-5xtcW:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
13
(Homo
sapiens) 		3 / 3 TRP W 116
VAL W 117
PRO W 118
 None
 0.69A 1rh0A-5xtcW:
undetectable		 1rh0A-5xtcW:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		5 / 12 ALA Q  44
GLY Q  49
LEU i 228
SER i 231
LEU i 175
 None
 1.01A 1ya4A-5xtcQ:
undetectable		 1ya4A-5xtcQ:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
8, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS c  54
ASP c  68
ASP c  74
 None
 0.79A 2br4D-5xtcc:
undetectable		 2br4D-5xtcc:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 5xtc ACYL CARRIER
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU X  87
TYR X  90
ILE X 118
GLY X 109
 None
 0.95A 2du8A-5xtcX:
undetectable		 2du8A-5xtcX:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		5 / 10 THR i 214
LEU i 249
GLY i 252
GLY i 259
THR i 333
 None
 1.13A 2wd9C-5xtci:
undetectable		 2wd9C-5xtci:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2
(Homo
sapiens) 		3 / 3 LEU g  62
TYR g  63
GLN g  60
 PLX  g 203 (-3.9A)
PLX  g 203 (-3.9A)
None
 0.74A 2wekA-5xtcg:
undetectable		 2wekA-5xtcg:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
10
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
11, MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		3 / 3 TYR d  57
GLU e 123
ASP d 102
 None
 0.76A 3bxoA-5xtcd:
undetectable		 3bxoA-5xtcd:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAS_A_ASDA332_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		5 / 10 TYR a 171
THR i 201
ASN i 197
VAL i 193
LEU i 149
 None
 1.43A 3casA-5xtca:
undetectable		 3casA-5xtca:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		5 / 12 ILE i  98
ALA i 101
LEU i  70
ALA i  66
LEU i 149
 None
 1.13A 3dzyA-5xtci:
undetectable		 3dzyA-5xtci:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
5
(Homo
sapiens) 		4 / 7 TRP h  40
PHE h  63
GLU h  39
ILE h  41
 None
 1.36A 3e7gA-5xtch:
undetectable
3e7gB-5xtch:
undetectable		 3e7gA-5xtch:
13.98
3e7gB-5xtch:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
11
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		3 / 3 ARG V 129
ILE i 277
THR i 156
 None
PEE  V 202 (-4.6A)
None
 0.75A 3ia4D-5xtcV:
undetectable		 3ia4D-5xtcV:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		5 / 12 PHE g  67
GLY g  37
ALA i 331
THR i 334
ILE i 209
 PLX  g 203 (-4.3A)
None
None
CDL  i 401 ( 4.3A)
PLX  g 201 ( 4.6A)
 1.20A 3ld6A-5xtcg:
undetectable		 3ld6A-5xtcg:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
11
(Homo
sapiens) 		4 / 8 ASP V  11
SER V  24
CYH V  75
ASP V  17
 None
 0.92A 3m0wE-5xtcV:
undetectable
3m0wF-5xtcV:
undetectable
3m0wG-5xtcV:
undetectable
3m0wH-5xtcV:
undetectable		 3m0wE-5xtcV:
19.31
3m0wF-5xtcV:
19.31
3m0wG-5xtcV:
19.31
3m0wH-5xtcV:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2
(Homo
sapiens) 		5 / 12 PRO g  21
ASP g  86
ARG g  85
ARG g  29
VAL g  75
 None
 1.44A 3p6gA-5xtcg:
undetectable		 3p6gA-5xtcg:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		5 / 12 LEU i 179
LEU i 248
ALA i 215
LEU i 211
LEU i 257
 None
 1.01A 3r9cA-5xtci:
1.2		 3r9cA-5xtci:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		5 / 12 GLY i 107
TYR i  59
ALA i  66
PRO i 138
LEU i  33
 None
 1.25A 3tm4A-5xtci:
undetectable		 3tm4A-5xtci:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		5 / 12 GLY i 107
TYR i  59
ALA i  66
PRO i 138
LEU i  33
 None
 1.27A 3tm4B-5xtci:
undetectable		 3tm4B-5xtci:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
10
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
11, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ILE d  96
TYR d  10
ILE d  99
ALA e 122
GLU e 123
 None
 1.32A 3u6tA-5xtcd:
undetectable		 3u6tA-5xtcd:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG a 123
ARG a 119
TRP a 110
 None
 1.35A 4b7nA-5xtca:
undetectable		 4b7nA-5xtca:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG a 123
ARG a 119
TRP a 110
 None
 1.33A 4cpzF-5xtca:
undetectable		 4cpzF-5xtca:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG a 123
ARG a 119
TRP a 110
 None
 1.36A 4cpzG-5xtca:
undetectable		 4cpzG-5xtca:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2
(Homo
sapiens) 		3 / 4 SER g  40
GLY g  71
GLU g  78
 None
 0.56A 4juoA-5xtcg:
undetectable
4juoC-5xtcg:
undetectable		 4juoA-5xtcg:
12.90
4juoC-5xtcg:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		4 / 6 LEU i 251
LEU i 179
MET i 187
VAL i 115
 None
 1.17A 4okbA-5xtci:
undetectable		 4okbA-5xtci:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
5
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Homo
sapiens) 		5 / 12 LEU h  18
LEU k  55
GLN h  25
THR i  85
ILE a 174
 None
 1.39A 4oktA-5xtch:
undetectable		 4oktA-5xtch:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 7 TRP Y  74
GLU Z  85
TYR Z  87
GLU Z  89
 None
 1.27A 4r87J-5xtcY:
undetectable
4r87L-5xtcY:
undetectable		 4r87J-5xtcY:
16.77
4r87L-5xtcY:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU f  68
ARG f  71
GLN f  61
 None
 0.97A 4rtbA-5xtcf:
undetectable		 4rtbA-5xtcf:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
10
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
11, MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		5 / 9 ILE d  96
TYR d  10
ILE d  99
ALA e 122
GLU e 123
 None
 1.37A 4yp2B-5xtcd:
undetectable		 4yp2B-5xtcd:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT 3
(Homo
sapiens) 		4 / 7 ILE U  31
LEU U  28
GLY U  26
GLY U  27
 None
None
PLX  U 101 (-3.4A)
PLX  U 101 ( 4.7A)
 0.87A 5a06B-5xtcU:
undetectable		 5a06B-5xtcU:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
10
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
11, MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		5 / 9 ILE d  96
TYR d  10
ILE d  99
ALA e 122
GLU e 123
 None
 1.39A 5cf9B-5xtcd:
undetectable		 5cf9B-5xtcd:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		4 / 4 ALA i 192
PRO i 262
LEU i 211
HIS i 186
 None
 1.46A 5eskA-5xtci:
undetectable		 5eskA-5xtci:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		4 / 6 ILE i 209
TYR i 208
PHE i 216
THR i 119
 PLX  g 201 ( 4.6A)
None
None
None
 0.96A 5g08A-5xtci:
undetectable		 5g08A-5xtci:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
5
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Homo
sapiens;
Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU i  75
LEU k  46
THR k  51
GLN h  25
 None
 1.20A 5hbsA-5xtci:
undetectable		 5hbsA-5xtci:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
5
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Homo
sapiens) 		5 / 12 LEU h  18
MET i  97
THR k  48
ALA k  44
LEU k  40
 None
 1.20A 5ienA-5xtch:
undetectable		 5ienA-5xtch:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Homo
sapiens;
Homo
sapiens) 		4 / 6 LEU i  71
ALA k  44
LEU k  40
SER k  39
 None
 1.28A 5l4iB-5xtci:
undetectable		 5l4iB-5xtci:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		3 / 3 THR i 132
THR i 333
LEU i 218
 PLX  g 201 (-4.0A)
None
None
 0.65A 5m66D-5xtci:
undetectable		 5m66D-5xtci:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
(Homo
sapiens) 		5 / 12 GLU i  34
LEU k  26
LEU i  61
ALA i  64
SER i  67
 None
 1.23A 5nd3B-5xtci:
undetectable		 5nd3B-5xtci:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT 1
NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
13
(Homo
sapiens;
Homo
sapiens) 		5 / 12 SER S  46
GLU S  49
LEU S  47
TYR W 143
PHE W 140
 None
None
None
None
PEE  W 201 (-3.5A)
 1.29A 5vlmF-5xtcS:
undetectable		 5vlmF-5xtcS:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
5
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens;
Homo
sapiens;
Homo
sapiens) 		4 / 7 THR i  89
ILE a 174
THR a 173
TYR h  60
 None
 0.82A 5zsfA-5xtci:
undetectable
5zsfB-5xtci:
undetectable		 5zsfA-5xtci:
11.80
5zsfB-5xtci:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
11
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		5 / 12 SER i 146
VAL V 141
ASN i 273
GLU i 268
VAL i 193
 None
 1.17A 6bqgA-5xtci:
2.4		 6bqgA-5xtci:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		4 / 5 LEU i  44
THR i 122
THR i 125
GLY i 127
 None
 1.28A 6gtqA-5xtci:
undetectable		 6gtqA-5xtci:
21.11