SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xtd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PHE J  64
VAL J 243
VAL J 352
ASP J 211
 None
None
None
NDP  J 401 ( 4.0A)
 1.24A 1dz6B-5xtdJ:
undetectable		 1dz6B-5xtdJ:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens) 		4 / 8 SER s 178
SER s 152
HIS s 304
PHE s 242
 None
 1.07A 1eqbA-5xtds:
undetectable
1eqbB-5xtds:
undetectable		 1eqbA-5xtds:
20.56
1eqbB-5xtds:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens) 		4 / 8 PHE s 242
SER s 178
SER s 152
HIS s 304
 None
 1.09A 1eqbA-5xtds:
undetectable
1eqbB-5xtds:
undetectable		 1eqbA-5xtds:
20.56
1eqbB-5xtds:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens) 		4 / 8 SER s 178
SER s 152
HIS s 304
PHE s 242
 None
 1.07A 1eqbC-5xtds:
undetectable
1eqbD-5xtds:
undetectable		 1eqbC-5xtds:
20.56
1eqbD-5xtds:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens) 		4 / 8 PHE s 242
SER s 178
SER s 152
HIS s 304
 None
 1.08A 1eqbC-5xtds:
undetectable
1eqbD-5xtds:
undetectable		 1eqbC-5xtds:
20.56
1eqbD-5xtds:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT 6
(Homo
sapiens) 		3 / 3 ARG E  60
THR E  46
VAL E  43
 None
 0.68A 1hxbA-5xtdE:
undetectable		 1hxbA-5xtdE:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE w  66
LEU w 114
GLN w 132
ARG w 161
ASP w 166
 None
 1.06A 1p5zB-5xtdw:
18.1		 1p5zB-5xtdw:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE w  66
LEU w 114
TYR w 118
ARG w 161
ASP w 166
 None
 1.11A 1p5zB-5xtdw:
18.1		 1p5zB-5xtdw:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE w  66
LEU w 114
TYR w 118
ASP w 166
GLU w 226
 None
 1.17A 1p5zB-5xtdw:
18.1		 1p5zB-5xtdw:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE J 249
GLY J 248
VAL J  69
VAL J 245
LEU J  65
 None
None
None
None
NDP  J 401 (-4.6A)
 1.09A 1vptA-5xtdJ:
undetectable		 1vptA-5xtdJ:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR J 235
GLY J 229
SER J 230
GLY J 232
ILE J 314
 None
 0.96A 2b25B-5xtdJ:
undetectable		 2b25B-5xtdJ:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 SER w 113
ASP w 223
CYH w  67
 None
 1.11A 2br4E-5xtdw:
undetectable		 2br4E-5xtdw:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU w 140
ILE w 195
PHE w 167
TYR w 187
ARG w 139
 None
 1.28A 2bxmA-5xtdw:
undetectable		 2bxmA-5xtdw:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2003_1
(SERUM ALBUMIN)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU w 140
ILE w 195
PHE w 167
TYR w 187
ARG w 139
 None
 1.38A 2bxqA-5xtdw:
undetectable		 2bxqA-5xtdw:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_A_ETVA302_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ILE w  66
LEU w 114
GLN w 132
ARG w 161
ASP w 166
TYR w 233
 None
 0.98A 2no6A-5xtdw:
17.6		 2no6A-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_A_ETVA302_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE w  66
LEU w 114
TYR w 118
ARG w 161
ASP w 166
 None
 1.01A 2no6A-5xtdw:
17.6		 2no6A-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_B_ETVB302_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE w  66
LEU w 114
GLN w 132
ARG w 161
ASP w 166
 None
 0.99A 2no6B-5xtdw:
18.4		 2no6B-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_B_ETVB302_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE w  66
LEU w 114
TYR w 118
ARG w 161
ASP w 166
 None
 1.02A 2no6B-5xtdw:
18.4		 2no6B-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_B_3TCB302_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE w  66
LEU w 114
GLN w 132
ARG w 161
ASP w 166
 None
 1.04A 2noaB-5xtdw:
18.3		 2noaB-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_B_3TCB302_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE w  66
LEU w 114
TYR w 118
ARG w 161
ASP w 166
 None
 1.08A 2noaB-5xtdw:
18.3		 2noaB-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT 6
(Homo
sapiens) 		3 / 3 ARG E  60
THR E  46
VAL E  43
 None
 0.84A 2q64A-5xtdE:
undetectable		 2q64A-5xtdE:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT 6
(Homo
sapiens) 		3 / 3 ARG E  60
THR E  46
VAL E  43
 None
 0.68A 2qakA-5xtdE:
undetectable		 2qakA-5xtdE:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens) 		4 / 5 PHE s  56
PHE s 223
SER s 209
ILE s 213
 None
 1.13A 2v0mD-5xtds:
undetectable		 2v0mD-5xtds:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE w  66
TYR w 118
GLN w 132
ARG w 161
TYR w 233
 None
 1.19A 2zi9A-5xtdw:
16.8		 2zi9A-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE w  66
TYR w 118
GLN w 132
GLU w 226
TYR w 233
 None
 1.00A 2zi9A-5xtdw:
16.8		 2zi9A-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 TYR w 118
GLN w 132
ARG w 139
ARG w 161
TYR w 233
 None
 1.18A 2zi9A-5xtdw:
16.8		 2zi9A-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 TYR w 118
GLN w 132
ARG w 139
GLU w 226
TYR w 233
 None
 1.08A 2zi9A-5xtdw:
16.8		 2zi9A-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ILE w  66
GLN w 132
ARG w 139
ARG w 161
GLU w 226
TYR w 233
 None
 1.09A 2ziaA-5xtdw:
18.3		 2ziaA-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ILE w  66
LEU w 114
GLN w 132
ARG w 161
GLU w 226
TYR w 233
 None
 1.01A 2ziaA-5xtdw:
18.3		 2ziaA-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ILE w  66
LEU w 114
TYR w 118
ARG w 161
GLU w 226
TYR w 233
 None
 1.26A 2ziaA-5xtdw:
18.3		 2ziaA-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ILE w  66
TYR w 118
ARG w 139
ARG w 161
GLU w 226
TYR w 233
 None
 1.19A 2ziaA-5xtdw:
18.3		 2ziaA-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ILE w  66
LEU w 114
TYR w 118
GLN w 132
GLU w 226
TYR w 233
 None
 1.12A 2ziaB-5xtdw:
18.4		 2ziaB-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ILE w  66
TYR w 118
ARG w 139
PHE w 169
GLU w 226
TYR w 233
 None
 1.50A 2ziaB-5xtdw:
18.4		 2ziaB-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ILE w  66
TYR w 118
GLN w 132
ARG w 139
GLU w 226
TYR w 233
 None
 1.08A 2ziaB-5xtdw:
18.4		 2ziaB-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens) 		5 / 11 THR s  87
ILE s  13
LEU s   6
LEU s  83
PRO s  12
 None
 1.35A 3a50B-5xtds:
undetectable		 3a50B-5xtds:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PHE J  64
GLY J  66
VAL J  70
LEU J  94
 None
 1.04A 3bgdB-5xtdJ:
undetectable		 3bgdB-5xtdJ:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE J 200
ALA J 198
PHE J 164
ALA J 153
 None
 0.93A 3hrdA-5xtdJ:
undetectable
3hrdB-5xtdJ:
undetectable		 3hrdA-5xtdJ:
20.55
3hrdB-5xtdJ:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL J 126
GLY J 160
ALA J 159
SER J 156
LEU J 155
 None
 0.99A 3hs6A-5xtdJ:
undetectable		 3hs6A-5xtdJ:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens) 		5 / 10 SER s 163
LEU s 237
ILE s 105
PRO s  88
GLY s 101
 None
 1.17A 3ijxB-5xtds:
undetectable
3ijxD-5xtds:
undetectable		 3ijxB-5xtds:
20.86
3ijxD-5xtds:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens) 		5 / 10 ILE s 105
PRO s  88
GLY s 101
SER s 163
LEU s 237
 None
 1.19A 3ik6B-5xtds:
undetectable
3ik6E-5xtds:
undetectable		 3ik6B-5xtds:
20.86
3ik6E-5xtds:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TYR w 233
GLU w 171
LEU w 234
ASN w  65
 None
 1.40A 3k8mA-5xtdw:
undetectable		 3k8mA-5xtdw:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens) 		4 / 7 GLU s 202
TYR s 228
GLU s 227
PHE s 220
 None
 1.37A 3ku9B-5xtds:
2.2		 3ku9B-5xtds:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG w 122
ASP w 236
GLN w 215
 None
 0.93A 3lcvB-5xtdw:
undetectable		 3lcvB-5xtdw:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ARG J 321
HIS J 169
ASP J 326
ASP J 211
LEU J 214
 None
NDP  J 401 (-3.9A)
None
NDP  J 401 ( 4.0A)
None
 1.45A 3lmyA-5xtdJ:
undetectable		 3lmyA-5xtdJ:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ILE w  66
GLN w 132
ARG w 161
ASP w 166
TYR w 233
 None
 1.02A 3mjrA-5xtdw:
17.0		 3mjrA-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ILE w  66
GLU w 160
ARG w 161
ASP w 166
TYR w 233
 None
 1.35A 3mjrA-5xtdw:
17.0		 3mjrA-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLN w 132
ARG w 139
ARG w 161
ASP w 166
 None
 1.20A 3mjrD-5xtdw:
16.5		 3mjrD-5xtdw:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ALA J 153
ILE J 152
HIS J 166
ASN J 128
 None
 1.12A 3nneG-5xtdJ:
undetectable		 3nneG-5xtdJ:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE J 116
ALA J 153
LEU J 155
ILE J 200
GLY J 187
 None
 0.87A 3ozwB-5xtdJ:
undetectable		 3ozwB-5xtdJ:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 LEU J 228
GLY J 229
GLY J 232
THR J 235
 None
 0.96A 3si7A-5xtdJ:
undetectable		 3si7A-5xtdJ:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS w 242
SER w 259
GLN w 257
 None
 1.36A 3si7A-5xtdw:
1.3		 3si7A-5xtdw:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU w 141
ALA w 146
THR w  97
PHE w  86
 None
 1.36A 3vasB-5xtdw:
2.2		 3vasB-5xtdw:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR J  62
PRO J  83
ILE J 152
VAL J 126
ILE J  81
 NDP  J 401 (-3.0A)
None
None
None
None
 1.31A 4eb6B-5xtdJ:
undetectable
4eb6C-5xtdJ:
undetectable		 4eb6B-5xtdJ:
21.77
4eb6C-5xtdJ:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT 6
(Homo
sapiens) 		3 / 3 GLU E  27
ASP E  24
ASP E  80
 None
 0.70A 4gc9A-5xtdE:
undetectable		 4gc9A-5xtdE:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 VAL J 250
ILE J 249
LYS J 261
ILE J 199
PHE J 265
 None
 1.49A 4laxA-5xtdJ:
undetectable		 4laxA-5xtdJ:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens) 		4 / 6 LEU s  83
MET s 225
MET s  17
ILE s 105
 None
 1.03A 4okxA-5xtds:
undetectable		 4okxA-5xtds:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY J 160
ALA J 159
PHE J 164
ALA J 153
VAL J 191
 None
 1.47A 4ryaA-5xtdJ:
undetectable		 4ryaA-5xtdJ:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS w 252
ARG w  58
VAL w  59
 None
 0.90A 4x3uA-5xtdw:
undetectable
4x3uB-5xtdw:
undetectable		 4x3uA-5xtdw:
12.21
4x3uB-5xtdw:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASP w  63
GLY w  71
ALA w  74
ILE w  60
ASP w 166
 None
 1.07A 4xe5A-5xtdw:
undetectable		 4xe5A-5xtdw:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens) 		4 / 8 LEU s 162
LEU s 103
THR s 108
MET s 233
 None
 1.15A 5hbsA-5xtds:
undetectable		 5hbsA-5xtds:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ASP w 119
ARG w 130
ASN w 111
ASN w 127
 None
 1.24A 5l6eA-5xtdw:
undetectable		 5l6eA-5xtdw:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens) 		4 / 7 LEU s 162
ILE s  81
THR s 108
MET s 233
 None
 1.17A 5ljcA-5xtds:
undetectable		 5ljcA-5xtds:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens) 		5 / 9 LEU s 162
LEU s 103
ILE s  81
THR s 108
MET s 233
 None
 1.27A 5ljdA-5xtds:
undetectable		 5ljdA-5xtds:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens) 		4 / 6 LEU s 103
ILE s  81
THR s 108
MET s 233
 None
 1.35A 5ljeA-5xtds:
undetectable		 5ljeA-5xtds:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ILE w  66
PRO w 121
GLN w 132
ARG w 161
GLU w 226
TYR w 233
 None
 1.09A 5mqtC-5xtdw:
17.3		 5mqtC-5xtdw:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 7 THR H  29
LEU H  27
THR H  52
VAL H  80
 None
 1.10A 5ov9A-5xtdH:
undetectable		 5ov9A-5xtdH:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens) 		4 / 9 ILE w 163
TYR w 307
ILE w  91
LEU w 114
 None
 0.83A 5vkqB-5xtdw:
undetectable
5vkqC-5xtdw:
undetectable		 5vkqB-5xtdw:
10.85
5vkqC-5xtdw:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens) 		4 / 7 THR s  67
LEU s  70
ILE s  72
THR s  73
 None
 1.00A 5zsfA-5xtds:
undetectable
5zsfB-5xtds:
undetectable		 5zsfA-5xtds:
12.32
5zsfB-5xtds:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLN J 341
THR J 343
HIS J  72
GLY J 339
 None
 1.15A 6gbnC-5xtdJ:
undetectable		 6gbnC-5xtdJ:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 TRP J 313
ASP J 133
ARG J 132
GLU J 311
 None
None
NDP  J 401 (-3.2A)
None
 1.23A 6mn4B-5xtdJ:
undetectable		 6mn4B-5xtdJ:
22.03