SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xtg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE
(Pseudomonas
sp.
MC1) 		4 / 8 ILE B 121
LEU B 125
LEU B 167
LEU B 128
 None
 0.87A 1eupA-5xtgB:
undetectable		 1eupA-5xtgB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE
(Pseudomonas
sp.
MC1) 		3 / 3 HIS B 158
ASP B  90
ASN B  94
 None
 0.81A 1wg8B-5xtgB:
9.3		 1wg8B-5xtgB:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE
(Pseudomonas
sp.
MC1) 		5 / 12 GLY B  11
GLY B  13
ASP B  58
VAL B  59
ILE B 112
 NAD  B 301 (-3.4A)
NAD  B 301 ( 3.9A)
NAD  B 301 (-2.3A)
NAD  B 301 (-3.9A)
NAD  B 301 ( 4.0A)
 0.89A 1zq9B-5xtgB:
5.7		 1zq9B-5xtgB:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE
(Pseudomonas
sp.
MC1) 		4 / 6 TYR B 153
ILE B 109
SER B 143
SER B 140
 NAD  B 301 (-4.7A)
None
None
NAD  B 301 (-2.1A)
 1.26A 3pmzD-5xtgB:
undetectable		 3pmzD-5xtgB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE
(Pseudomonas
sp.
MC1) 		4 / 5 ILE B  16
PRO B 224
SER B 188
GLY B  15
 NAD  B 301 (-3.7A)
None
BPY  B 303 ( 4.9A)
NAD  B 301 (-3.2A)
 1.12A 3tkdB-5xtgB:
undetectable		 3tkdB-5xtgB:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE
(Pseudomonas
sp.
MC1) 		4 / 5 ILE B  16
PRO B 224
SER B 188
GLY B  15
 NAD  B 301 (-3.7A)
None
BPY  B 303 ( 4.9A)
NAD  B 301 (-3.2A)
 1.11A 3tkdA-5xtgB:
undetectable		 3tkdA-5xtgB:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE
(Pseudomonas
sp.
MC1) 		5 / 12 GLY B 147
GLY B 148
GLY B 149
TYR B 153
SER B 142
 None
None
None
NAD  B 301 (-4.7A)
NAD  B 301 ( 4.8A)
 0.90A 4ey6A-5xtgB:
2.6		 4ey6A-5xtgB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE
(Pseudomonas
sp.
MC1) 		4 / 5 GLY B 120
SER B 122
ALA B 123
GLU B  66
 None
 1.07A 4m93B-5xtgB:
undetectable
4m93C-5xtgB:
undetectable		 4m93B-5xtgB:
20.79
4m93C-5xtgB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE
(Pseudomonas
sp.
MC1) 		4 / 4 PHE B  48
VAL B  31
ALA B  51
PHE B  76
 None
 1.50A 4z4gA-5xtgB:
2.5		 4z4gA-5xtgB:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE
(Pseudomonas
sp.
MC1) 		3 / 3 VAL B  31
ALA B  51
PHE B  76
 None
 0.89A 4z4iA-5xtgB:
3.4		 4z4iA-5xtgB:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE
(Pseudomonas
sp.
MC1) 		4 / 5 SER B 142
SER B 143
SER B 140
SER B 156
 NAD  B 301 ( 4.8A)
None
NAD  B 301 (-2.1A)
None
 1.08A 5hswA-5xtgB:
undetectable		 5hswA-5xtgB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE
(Pseudomonas
sp.
MC1) 		3 / 3 VAL B  31
ALA B  51
PHE B  76
 None
 0.87A 5js1A-5xtgB:
undetectable		 5js1A-5xtgB:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE
(Pseudomonas
sp.
MC1) 		5 / 12 GLY B  11
GLY B  13
GLN B  40
ASP B  58
VAL B  59
 NAD  B 301 (-3.4A)
NAD  B 301 ( 3.9A)
NAD  B 301 (-3.2A)
NAD  B 301 (-2.3A)
NAD  B 301 (-3.9A)
 0.84A 5kpcB-5xtgB:
5.6		 5kpcB-5xtgB:
23.80