SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xto'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrov
irus)
5 / 12 LEU A   7
GLU A 251
LEU A 258
GLY A 250
MET A 247
None
None
None
None
FAD  A 301 ( 4.9A)
1.30A 1d4fA-5xtoA:
undetectable
1d4fA-5xtoA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrov
irus)
4 / 6 ILE A 178
GLU A 183
LEU A 132
LEU A 139
None
0.89A 1mt1B-5xtoA:
undetectable
1mt1C-5xtoA:
undetectable
1mt1B-5xtoA:
16.04
1mt1C-5xtoA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrov
irus)
4 / 7 THR A  43
ASN A 148
LEU A  22
GLN A  41
None
1.08A 1qzrA-5xtoA:
undetectable
1qzrA-5xtoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrov
irus)
4 / 7 THR A  43
ASN A 148
LEU A  22
GLN A  41
None
1.05A 1qzrB-5xtoA:
undetectable
1qzrB-5xtoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrov
irus)
4 / 4 LYS A  88
LEU A  92
LEU A  94
SER A  96
None
1.10A 1tt6A-5xtoA:
undetectable
1tt6A-5xtoA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrov
irus)
5 / 12 ALA A 202
ALA A 179
LEU A 216
ILE A 176
HIS A 172
None
1.01A 2h77A-5xtoA:
undetectable
2h77A-5xtoA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrov
irus)
5 / 12 ALA A 202
ALA A 179
LEU A 216
ILE A 176
HIS A 172
None
1.04A 2h79A-5xtoA:
undetectable
2h79A-5xtoA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrov
irus)
4 / 5 LEU A 212
LEU A 216
LEU A 118
MET A 142
None
1.08A 2oaxF-5xtoA:
undetectable
2oaxF-5xtoA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrov
irus)
4 / 7 LEU A 132
LEU A 139
ILE A 178
GLU A 183
None
1.04A 2qqdA-5xtoA:
undetectable
2qqdE-5xtoA:
undetectable
2qqdA-5xtoA:
10.96
2qqdE-5xtoA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrov
irus)
4 / 8 HIS A 225
TYR A 252
ASP A 111
ARG A  10
FAD  A 301 (-3.3A)
FAD  A 301 ( 4.4A)
None
FAD  A 301 (-3.5A)
0.93A 2v57A-5xtoA:
undetectable
2v57A-5xtoA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrov
irus)
4 / 8 HIS A 225
TYR A 252
ASP A 111
ARG A  10
FAD  A 301 (-3.3A)
FAD  A 301 ( 4.4A)
None
FAD  A 301 (-3.5A)
0.92A 2v57C-5xtoA:
undetectable
2v57C-5xtoA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrov
irus)
5 / 12 ALA A 202
ALA A 179
LEU A 216
ILE A 176
HIS A 172
None
1.02A 3gwsX-5xtoA:
undetectable
3gwsX-5xtoA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrov
irus)
3 / 3 GLU A 177
LEU A 180
ASP A 181
None
0.40A 3ko0T-5xtoA:
undetectable
3ko0T-5xtoA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrov
irus)
5 / 12 ALA A 202
ALA A 179
LEU A 216
ILE A 176
HIS A 172
None
1.03A 4lnwA-5xtoA:
undetectable
4lnwA-5xtoA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)
5xto FAD-LINKED
SULFHYDRYL OXIDASE

(Autographa
californica
multiple
nucleopolyhedrov
irus)
5 / 12 ALA A 202
ALA A 179
LEU A 216
ILE A 176
HIS A 172
None
1.05A 4lnxA-5xtoA:
undetectable
4lnxA-5xtoA:
19.68