SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xts'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 5xts MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens) 		5 / 12 PHE A 174
GLY A 195
LYS A 204
ASP A 203
THR A 197
 None
 1.16A 3a25A-5xtsA:
undetectable		 3a25A-5xtsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 5xts MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens) 		4 / 4 GLY A 415
ASP A 420
GLY A 483
THR A 399
 None
 1.00A 3k4vC-5xtsA:
undetectable		 3k4vC-5xtsA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5xts MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens) 		4 / 4 LEU A 426
GLY A 425
MET A 466
PHE A 445
 None
 1.39A 3vaqB-5xtsA:
undetectable		 3vaqB-5xtsA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 5xts MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens) 		3 / 3 ARG A 151
ARG A  23
ILE A 141
 None
 0.92A 4b7qC-5xtsA:
undetectable		 4b7qC-5xtsA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5xts MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens) 		5 / 12 LEU A 273
LEU A 277
SER A 246
GLY A 161
LEU A 160
 None
 0.86A 6b0iB-5xtsA:
undetectable		 6b0iB-5xtsA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5xts MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens) 		5 / 12 LEU A 273
LEU A 277
SER A 246
GLY A 161
LEU A 160
 None
 0.82A 6b0lB-5xtsA:
undetectable		 6b0lB-5xtsA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 5xts MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens) 		4 / 6 HIS A 377
TYR A 484
GLU A 380
LYS A 382
 None
 1.30A 6d8pA-5xtsA:
undetectable		 6d8pA-5xtsA:
undetectable